Real-time monitoring radiofrequency ablation using tree-based ensemble learning models.

BACKGROUND: Radiofrequency ablation is a minimally-invasive treatment method that aims to destroy undesired tissue by exposing it to alternating current in the 100 kHz-800 kHz frequency range and heating it until it is destroyed via coagulative necrosis. Ablation treatment is gaining momentum especially in cancer research, where the undesired tissue is a malignant tumor. While ablating the tumor with an electrode or catheter is an easy task, real-time monitoring the ablation process is a must in order to maintain the reliability of the treatment. Common methods for this monitoring task have proven to be accurate, however, they are all time-consuming or require expensive equipment, which makes the clinical ablation process more cumbersome and expensive due to the time-dependent nature of the clinical procedure. METHODS: A machine learning (ML) approach is presented that aims to reduce the monitoring time while keeping the accuracy of the conventional methods. Two different hardware setups are used to perform the ablation and collect impedance data at the same time and different ML algorithms are tested to predict the ablation depth in 3 dimensions, based on the collected data. RESULTS: Both the random forest and adaptive boosting (adaboost) models had over 98% R2 on the data collected with the embedded system-based hardware instrumentation setup, outperforming Neural Network-based models. CONCLUSIONS: It is shown that an optimal pair of hardware setup and ML algorithm (Adaboost) is able to control the ablation by estimating the lesion depth within a test average of 0.3mm while keeping the estimation time within 10ms on a ×86-64 workstation.

Inter-Patient Atrial Flutter Classification Using FFT-Based Features and a Low-Variance Stacking Classifier.

OBJECTIVE: Atrial Flutter (AFL) is a supraventricular tachyarrhythmia typically arising from a macroreentry circuit that can have variable atrial anatomy. It is often treated by catheter ablation, the success of which depends upon the correct determination of the electroanatomic circuit, generally through invasive electrophysiological (EP) study. We hypothesized that machine learning (ML) methods applied to the diagnostic 12-lead surface electrocardiogram (ECG) could determine the specific circuit prior to any invasive EP study. METHODS: The 12-lead ECGs were reduced to eight independent leads: I, II, V1 - V6. Through an algorithm using ventricular complex cancellation methods, windows of atrial activity in the ECG were uncovered and spectra were generated. Three ML classifier approaches were applied: Support Vector Machine (SVM), Random Forest (RF) and k-Nearest Neighbors (KNN), and their outputs combined using soft voting. RESULTS: Ten-second surface ECGs taken from 419 AFL patients prior to invasive EP study and ablation were analyzed retrospectively. Of the 419 patients, 285 had typical cavotricuspid isthmus (CTI)-dependent AFL, 41 had atypical right-atrial AFL and 93 had left-atrial AFL, as determined during the subsequent EP study. Lead V5 was found to be most useful giving a test accuracy of 98% and f1 score of 0.97. CONCLUSION: We conclude that ML methods have the potential to automatically determine the AFL macroreentry circuit from the surface ECG. SIGNIFICANCE: The AFL classification method presented in this investigation achieves 95+% accuracy on an unbalanced inter-patient dataset which has important clinical applications.

Real-Time Radiofrequency Ablation Lesion Depth Estimation Using Multi-frequency Impedance With a Deep Neural Network and Tree-Based Ensembles.

OBJECTIVE: Design and optimization of statistical models for use in methods for estimating radiofrequency ablation (RFA) lesion depths in soft real-time performance. METHODS: Using tissue multi-frequency complex electrical impedance data collected from a low-cost embedded system, a deep neural network (NN) and tree-based ensembles (TEs) were trained for estimating the RFA lesion depth via regression. RESULTS: Addition of frequency sweep data, previous depth data, and previous RF power state data boosted accuracy of the statistical models. The root mean square errors were 2 mm for NN and 0.5 mm for TEs for previous statistical models and the root mean square errors were 0.4 mm for NN and 0.04 mm for TEs for the statistical models presented in this paper. Simulation ablation performance showed a mean difference against physical measurements of 0.5 ±0.2 mm for the NN-based depth estimation method and 0.7 ±0.4 mm for the TE-based depth estimation method. CONCLUSION: The results show that multi-frequency data significantly improves the depth estimation performance of the statistical models. SIGNIFICANCE: The RFA lesion depth estimation methods presented in this work achieve millimeter-resolution accuracy with soft real-time performance on an ARMv7-based embedded system for potential translation to clinical RFA technologies.

Early and Late Fusion Machine Learning on Multi-Frequency Electrical Impedance Data to Improve Radiofrequency Ablation Monitoring.

Radiofrequency ablation (RFA) is a popular modality for tumor treatment. However, inexpensive real-time monitoring of RFA within multiple tissue types is still an ongoing research topic. The objective of this study is to utilize multi-frequency electrical impedance data within real-time RFA depth estimation through data fusion schemes that include non-linear machine learning (ML) models. Multi-frequency tissue complex electrical impedance measurements are used to provide input data to the data fusion schemes. Our results show that the fusion schemes significantly decrease both the spread of residuals and the mean of the residuals for depth estimation. Thus, data fusion can be a significant tool for use in improving the performance of ML-based monitoring for RFA.