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1.
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.
Bioorg Med Chem;
79: 117150, 2023 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36640594
2.
Esmethadone-HCl (REL-1017): a promising rapid antidepressant.
Eur Arch Psychiatry Clin Neurosci;
273(7): 1463-1476, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36890259
3.
Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity.
Bioorg Med Chem;
56: 116576, 2022 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35051811
4.
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling.
Int J Mol Sci;
23(20)2022 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36293063
5.
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Bioorg Med Chem Lett;
22(7): 2620-3, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22366657
6.
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin.
Pharmaceuticals (Basel);
15(7)2022 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-35890179
7.
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors.
Pharmaceuticals (Basel);
15(8)2022 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36015145
8.
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.
Am J Psychiatry;
179(2): 122-131, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34933568
9.
Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists.
Bioorg Med Chem Lett;
21(7): 2059-63, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21334205
10.
Identification of novel NK1/NK3 dual antagonists for the potential treatment of schizophrenia.
Bioorg Med Chem Lett;
21(22): 6899-904, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21974957
11.
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
J Pharmacol Exp Ther;
335(3): 636-44, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20810618
12.
The identification of novel orally active mGluR5 antagonist GSK2210875.
Bioorg Med Chem Lett;
20(24): 7521-4, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21051228
13.
Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium.
J Mol Histol;
38(6): 571-9, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17849223
14.
Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells.
Neurosci Lett;
317(1): 50-2, 2002 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11750994
15.
NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development.
Neuropharmacology;
62(2): 925-32, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22001284
16.
Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties.
J Biol Chem;
277(7): 4790-6, 2002 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11719522
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