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1.

Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma.

Flint, Alyssa C; Mitchell, Dana K; Angus, Steven P; Smith, Abbi E; Bessler, Waylan; Jiang, Li; Mang, Henry; Li, Xiaohong; Lu, Qingbo; Rodriguez, Brooke; Sandusky, George E; Masters, Andi R; Zhang, Chi; Dang, Pengtao; Koenig, Jenna; Johnson, Gary L; Shen, Weihua; Liu, Jiangang; Aggarwal, Amit; Donoho, Gregory P; Willard, Melinda D; Bhagwat, Shripad V; Clapp, D Wade; Rhodes, Steven D.

Clin Cancer Res; 29(17): 3438-3456, 2023 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-37406085

2.

Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.

Crew, Andrew P; Bhagwat, Shripad V; Dong, Hanqing; Bittner, Mark A; Chan, Anna; Chen, Xin; Coate, Heather; Cooke, Andrew; Gokhale, Prafulla C; Honda, Ayako; Jin, Meizhong; Kahler, Jennifer; Mantis, Christine; Mulvihill, Mark J; Tavares-Greco, Paula A; Volk, Brian; Wang, Jing; Werner, Douglas S; Arnold, Lee D; Pachter, Jonathan A; Wild, Robert; Gibson, Neil W.

Bioorg Med Chem Lett; 21(7): 2092-7, 2011 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-21353551

3.

ERK Inhibitor LY3214996-Based Treatment Strategies for RAS-Driven Lung Cancer.

Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Jänne, Pasi A.

Mol Cancer Ther; 20(4): 641-654, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33536188

4.

Correction: Evaluation of ERK as a therapeutic target in acute myelogenous leukemia.

Weisberg, Ellen; Meng, Chengcheng; Case, Abigail; Sattler, Martin; Tiv, Hong L; Gokhale, Prafulla C; Buhrlage, Sara; Wang, Jinhua; Gray, Nathanael; Stone, Richard; Liu, Suiyang; Bhagwat, Shripad V; Tiu, Ramon V; Adamia, Sophia; Griffin, James D.

Leukemia; 34(9): 2543, 2020 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-32144400

5.

Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis.

Liu, Jiangang; Cho, Yong Beom; Hong, Hye Kyung; Wu, Song; Ebert, Philip J; Bray, Steven M; Wong, Swee Seong; Ting, Jason C; Calley, John N; Whittington, Catherine F; Bhagwat, Shripad V; Reinhard, Christoph; Wild, Robert; Nam, Do-Hyun; Aggarwal, Amit; Lee, Woo Yong; Peng, Sheng-Bin.

Sci Rep; 10(1): 10725, 2020 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-32612211

6.

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.

Ozkan-Dagliyan, Irem; Diehl, J Nathaniel; George, Samuel D; Schaefer, Antje; Papke, Bjoern; Klotz-Noack, Kathleen; Waters, Andrew M; Goodwin, Craig M; Gautam, Prson; Pierobon, Mariaelena; Peng, Sen; Gilbert, Thomas S K; Lin, Kevin H; Dagliyan, Onur; Wennerberg, Krister; Petricoin, Emanuel F; Tran, Nhan L; Bhagwat, Shripad V; Tiu, Ramon V; Peng, Sheng-Bin; Herring, Laura E; Graves, Lee M; Sers, Christine; Wood, Kris C; Cox, Adrienne D; Der, Channing J.

Cell Rep; 31(11): 107764, 2020 06 16.

Artículo en Inglés | MEDLINE | ID: mdl-32553168

7.

ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine.

Bhagwat, Shripad V; McMillen, William T; Cai, Shufen; Zhao, Baohui; Whitesell, Matthew; Shen, Weihua; Kindler, Lisa; Flack, Robert S; Wu, Wenjuan; Anderson, Bryan; Zhai, Yan; Yuan, Xiu-Juan; Pogue, Meghann; Van Horn, Robert D; Rao, Xi; McCann, Denis; Dropsey, Andrew J; Manro, Jason; Walgren, Jennie; Yuen, Eunice; Rodriguez, Michael J; Plowman, Gregory D; Tiu, Ramon V; Joseph, Sajan; Peng, Sheng-Bin.

Mol Cancer Ther; 19(2): 325-336, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31744895

8.

Correction: Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma.

Flint, Alyssa C; Mitchell, Dana K; Angus, Steven P; Smith, Abbi E; Bessler, Waylan; Jiang, Li; Mang, Henry; Li, Xiaohong; Lu, Qingbo; Rodriguez, Brooke; Sandusky, George E; Masters, Andi R; Zhang, Chi; Dang, Pengtao; Koenig, Jenna; Johnson, Gary L; Shen, Weihua; Liu, Jiangang; Aggarwal, Amit; Donoho, Gregory P; Willard, Melinda D; Bhagwat, Shripad V; Clapp, D Wade; Rhodes, Steven D.

Clin Cancer Res; 30(9): 1992, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38690594

9.

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy.

Du, Jian; Yan, Lei; Torres, Raquel; Gong, Xueqian; Bian, Huimin; Marugán, Carlos; Boehnke, Karsten; Baquero, Carmen; Hui, Yu-Hua; Chapman, Sonya C; Yang, Yanzhu; Zeng, Yi; Bogner, Sarah M; Foreman, Robert T; Capen, Andrew; Donoho, Gregory P; Van Horn, Robert D; Barnard, Darlene S; Dempsey, Jack A; Beckmann, Richard P; Marshall, Mark S; Chio, Li-Chun; Qian, Yuewei; Webster, Yue W; Aggarwal, Amit; Chu, Shaoyou; Bhattachar, Shobha; Stancato, Louis F; Dowless, Michele S; Iversen, Phillip W; Manro, Jason R; Walgren, Jennie L; Halstead, Bartley W; Dieter, Matthew Z; Martinez, Ricardo; Bhagwat, Shripad V; Kreklau, Emiko L; Lallena, Maria Jose; Ye, Xiang S; Patel, Bharvin K R; Reinhard, Christoph; Plowman, Gregory D; Barda, David A; Henry, James R; Buchanan, Sean G; Campbell, Robert M.

Mol Cancer Ther; 18(12): 2207-2219, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31530649

10.

Evaluation of ERK as a therapeutic target in acute myelogenous leukemia.

Weisberg, Ellen; Meng, Chengcheng; Case, Abigail; Sattler, Martin; Tiv, Hong L; Gokhale, Prafulla C; Buhrlage, Sara; Wang, Jinhua; Gray, Nathanael; Stone, Richard; Liu, Suiyang; Bhagwat, Shripad V; Tiu, Ramon V; Adamia, Sophia; Griffin, James D.

Leukemia; 34(2): 625-629, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31455850

11.

Identification of druggable cancer driver genes amplified across TCGA datasets.

Chen, Ying; McGee, Jeremy; Chen, Xianming; Doman, Thompson N; Gong, Xueqian; Zhang, Youyan; Hamm, Nicole; Ma, Xiwen; Higgs, Richard E; Bhagwat, Shripad V; Buchanan, Sean; Peng, Sheng-Bin; Staschke, Kirk A; Yadav, Vipin; Yue, Yong; Kouros-Mehr, Hosein.

PLoS One; 9(5): e98293, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24874471

12.

Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.

Bhagwat, Shripad V; Gokhale, Prafulla C; Crew, Andrew P; Cooke, Andy; Yao, Yan; Mantis, Christine; Kahler, Jennifer; Workman, Jennifer; Bittner, Mark; Dudkin, Lorina; Epstein, David M; Gibson, Neil W; Wild, Robert; Arnold, Lee D; Houghton, Peter J; Pachter, Jonathan A.

Mol Cancer Ther; 10(8): 1394-406, 2011 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-21673091

13.

Novel inhibitors of mTORC1 and mTORC2.

Bhagwat, Shripad V; Crew, Andrew P.

Curr Opin Investig Drugs; 11(6): 638-45, 2010 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-20496258

14.

High-throughput screening for mTORC1/mTORC2 kinase inhibitors using a chemiluminescence-based ELISA assay.

Bhagwat, Shripad V; Kahler, Jennifer; Yao, Yan; Maresca, Paul; Brooks, Maureen; Crew, Andy; Boisclair, Michael; Pachter, Jonathan A.

Assay Drug Dev Technol; 7(5): 471-8, 2009 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-19895344

15.

Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes.

Raza, Haider; Bhagwat, Shripad V; John, Annie.

Comp Biochem Physiol C Toxicol Pharmacol; 139(4): 289-93, 2004 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-15683840

16.

CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells.

Petrovic, Nenad; Bhagwat, Shripad V; Ratzan, William J; Ostrowski, Michael C; Shapiro, Linda H.

J Biol Chem; 278(49): 49358-68, 2003 Dec 05.

Artículo en Inglés | MEDLINE | ID: mdl-14507917

17.

The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis.

Bhagwat, Shripad V; Petrovic, Nenad; Okamoto, Yasuhiro; Shapiro, Linda H.

Blood; 101(5): 1818-26, 2003 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-12406907

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