Oxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO2 Ceramic Tiles.

The current SARS-CoV-2 pandemic causes serious public health, social, and economic issues all over the globe. Surface transmission has been claimed as a possible SARS-CoV-2 infection route, especially in heavy contaminated environmental surfaces, including hospitals and crowded public places. Herein, we studied the deactivation of SARS-CoV-2 on photoactive AgNPs@TiO2 coated on industrial ceramic tiles under dark, UVA, and LED light irradiations. SARS-CoV-2 inactivation is effective under any light/dark conditions. The presence of AgNPs has an important key to limit the survival of SARS-CoV-2 in the dark; moreover, there is a synergistic action when TiO2 is decorated with Ag to enhance the virus photocatalytic inactivation even under LED. The radical oxidation was confirmed as the the central mechanism behind SARS-CoV-2 damage/inactivation by ESR analysis under LED light. Therefore, photoactive AgNPs@TiO2 ceramic tiles could be exploited to fight surface infections, especially during viral severe pandemics.

Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals.

Alanine, arginine and aspartic acid have been used as co-reagents during the synthesis of a biomimetic calcium-deficient hydroxyapatite (CDHA) for the synergistic coupling of synthesis and functionalization. The surface and bulk characterizations are consistent with a binding model in which the amino acid is preferentially bound to the CDHA nanocrystal surface by its lateral chain group. The zeta-potential measurements show that the amino acid-functionalized CDHA surface charge shifts towards neutral compared to CDHA synthesized in the absence of amino acids. Amino acids bound to the crystal induce crystal growth inhibition predominantly at the Ca-rich surfaces during the initial stages of crystallization. Moreover, high-resolution transmission electron microscopy measurements suggest a model for needle-shaped CDHA nanocrystals formation in the presence of either arginine or aspartic acid based on the oriented aggregation of primary crystallite domains specifically along the c-axis direction and the self-assembly of preformed nanoparticles. The results have significant importance for the control of the shape, morphology and aggregation of the CDHA nanocrystals, while the observed surface modifications are of marked importance for the nature, stability and reactivity of the functionalized surfaces produced.