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1.

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage.

Stanway, Rebecca R; Bushell, Ellen; Chiappino-Pepe, Anush; Roques, Magali; Sanderson, Theo; Franke-Fayard, Blandine; Caldelari, Reto; Golomingi, Murielle; Nyonda, Mary; Pandey, Vikash; Schwach, Frank; Chevalley, Séverine; Ramesar, Jai; Metcalf, Tom; Herd, Colin; Burda, Paul-Christian; Rayner, Julian C; Soldati-Favre, Dominique; Janse, Chris J; Hatzimanikatis, Vassily; Billker, Oliver; Heussler, Volker T.

Cell; 179(5): 1112-1128.e26, 2019 11 14.

Artículo en Inglés | MEDLINE | ID: mdl-31730853

2.

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell, Ellen; Gomes, Ana Rita; Sanderson, Theo; Anar, Burcu; Girling, Gareth; Herd, Colin; Metcalf, Tom; Modrzynska, Katarzyna; Schwach, Frank; Martin, Rowena E; Mather, Michael W; McFadden, Geoffrey I; Parts, Leopold; Rutledge, Gavin G; Vaidya, Akhil B; Wengelnik, Kai; Rayner, Julian C; Billker, Oliver.

Cell; 170(2): 260-272.e8, 2017 07 13.

Artículo en Inglés | MEDLINE | ID: mdl-28708996

3.

Nutrient sensing modulates malaria parasite virulence.

Mancio-Silva, Liliana; Slavic, Ksenija; Grilo Ruivo, Margarida T; Grosso, Ana Rita; Modrzynska, Katarzyna K; Vera, Iset Medina; Sales-Dias, Joana; Gomes, Ana Rita; MacPherson, Cameron Ross; Crozet, Pierre; Adamo, Mattia; Baena-Gonzalez, Elena; Tewari, Rita; Llinás, Manuel; Billker, Oliver; Mota, Maria M.

Nature; 547(7662): 213-216, 2017 07 13.

Artículo en Inglés | MEDLINE | ID: mdl-28678779

4.

Systematic Identification of Plasmodium Falciparum Sporozoite Membrane Protein Interactions Reveals an Essential Role for the p24 Complex in Host Infection.

Knöckel, Julia; Dundas, Kirsten; Yang, Annie S P; Galaway, Francis; Metcalf, Tom; Gemert, Geert-Jan van; Sauerwein, Robert W; Rayner, Julian C; Billker, Oliver; Wright, Gavin J.

Mol Cell Proteomics; 20: 100038, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33515807

5.

Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals.

Böhme, Ulrike; Otto, Thomas D; Cotton, James A; Steinbiss, Sascha; Sanders, Mandy; Oyola, Samuel O; Nicot, Antoine; Gandon, Sylvain; Patra, Kailash P; Herd, Colin; Bushell, Ellen; Modrzynska, Katarzyna K; Billker, Oliver; Vinetz, Joseph M; Rivero, Ana; Newbold, Chris I; Berriman, Matthew.

Genome Res; 28(4): 547-560, 2018 04.

Artículo en Inglés | MEDLINE | ID: mdl-29500236

6.

Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP.

Dundas, Kirsten; Shears, Melanie J; Sun, Yi; Hopp, Christine S; Crosnier, Cecile; Metcalf, Tom; Girling, Gareth; Sinnis, Photini; Billker, Oliver; Wright, Gavin J.

Proc Natl Acad Sci U S A; 115(17): 4477-4482, 2018 04 24.

Artículo en Inglés | MEDLINE | ID: mdl-29632205

7.

Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.

Ning, Jue; Otto, Thomas D; Pfander, Claudia; Schwach, Frank; Brochet, Mathieu; Bushell, Ellen; Goulding, David; Sanders, Mandy; Lefebvre, Paul A; Pei, Jimin; Grishin, Nick V; Vanderlaan, Gary; Billker, Oliver; Snell, William J.

Genes Dev; 27(10): 1198-215, 2013 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-23699412

8.

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.

Sinha, Abhinav; Hughes, Katie R; Modrzynska, Katarzyna K; Otto, Thomas D; Pfander, Claudia; Dickens, Nicholas J; Religa, Agnieszka A; Bushell, Ellen; Graham, Anne L; Cameron, Rachael; Kafsack, Bjorn F C; Williams, April E; Llinas, Manuel; Berriman, Matthew; Billker, Oliver; Waters, Andrew P.

Nature; 507(7491): 253-257, 2014 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-24572359

9.

Calcium signalling in malaria parasites.

Brochet, Mathieu; Billker, Oliver.

Mol Microbiol; 100(3): 397-408, 2016 05.

Artículo en Inglés | MEDLINE | ID: mdl-26748879

10.

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

Chertow, Jessica H; Alkaitis, Matthew S; Nardone, Glenn; Ikeda, Allison K; Cunnington, Aubrey J; Okebe, Joseph; Ebonyi, Augustine O; Njie, Madi; Correa, Simon; Jayasooriya, Shamanthi; Casals-Pascual, Climent; Billker, Oliver; Conway, David J; Walther, Michael; Ackerman, Hans.

PLoS Pathog; 11(9): e1005119, 2015 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-26407009

11.

Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium.

Hopp, Christine S; Balaban, Amanda E; Bushell, Ellen S C; Billker, Oliver; Rayner, Julian C; Sinnis, Photini.

Cell Microbiol; 18(11): 1625-1641, 2016 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-27084458

12.

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²âº signals at key decision points in the life cycle of malaria parasites.

Brochet, Mathieu; Collins, Mark O; Smith, Terry K; Thompson, Eloise; Sebastian, Sarah; Volkmann, Katrin; Schwach, Frank; Chappell, Lia; Gomes, Ana Rita; Berriman, Matthew; Rayner, Julian C; Baker, David A; Choudhary, Jyoti; Billker, Oliver.

PLoS Biol; 12(3): e1001806, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24594931

13.

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.

Schwach, Frank; Bushell, Ellen; Gomes, Ana Rita; Anar, Burcu; Girling, Gareth; Herd, Colin; Rayner, Julian C; Billker, Oliver.

Nucleic Acids Res; 43(Database issue): D1176-82, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25593348

14.

Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.

Alkaitis, Matthew S; Wang, Honghui; Ikeda, Allison K; Rowley, Carol A; MacCormick, Ian J C; Chertow, Jessica H; Billker, Oliver; Suffredini, Anthony F; Roberts, David J; Taylor, Terrie E; Seydel, Karl B; Ackerman, Hans C.

J Infect Dis; 214(12): 1840-1849, 2016 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-27923948

15.

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.

Oppenheim, Rebecca D; Creek, Darren J; Macrae, James I; Modrzynska, Katarzyna K; Pino, Paco; Limenitakis, Julien; Polonais, Valerie; Seeber, Frank; Barrett, Michael P; Billker, Oliver; McConville, Malcolm J; Soldati-Favre, Dominique.

PLoS Pathog; 10(7): e1004263, 2014 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25032958

16.

Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.

Frénal, Karine; Tay, Chwen L; Mueller, Christina; Bushell, Ellen S; Jia, Yonggen; Graindorge, Arnault; Billker, Oliver; Rayner, Julian C; Soldati-Favre, Dominique.

Traffic; 14(8): 895-911, 2013 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-23638681

17.

The malarial serine protease SUB1 plays an essential role in parasite liver stage development.

Suarez, Catherine; Volkmann, Katrin; Gomes, Ana Rita; Billker, Oliver; Blackman, Michael J.

PLoS Pathog; 9(12): e1003811, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-24348254

18.

A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Otto, Thomas D; Böhme, Ulrike; Jackson, Andrew P; Hunt, Martin; Franke-Fayard, Blandine; Hoeijmakers, Wieteke A M; Religa, Agnieszka A; Robertson, Lauren; Sanders, Mandy; Ogun, Solabomi A; Cunningham, Deirdre; Erhart, Annette; Billker, Oliver; Khan, Shahid M; Stunnenberg, Hendrik G; Langhorne, Jean; Holder, Anthony A; Waters, Andrew P; Newbold, Chris I; Pain, Arnab; Berriman, Matthew; Janse, Chris J.

BMC Biol; 12: 86, 2014 Oct 30.

Artículo en Inglés | MEDLINE | ID: mdl-25359557

19.

Efficacy of a Plasmodium vivax malaria vaccine using ChAd63 and modified vaccinia Ankara expressing thrombospondin-related anonymous protein as assessed with transgenic Plasmodium berghei parasites.

Bauza, Karolis; Malinauskas, Tomas; Pfander, Claudia; Anar, Burcu; Jones, E Yvonne; Billker, Oliver; Hill, Adrian V S; Reyes-Sandoval, Arturo.

Infect Immun; 82(3): 1277-86, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24379295

20.

A scalable pipeline for highly effective genetic modification of a malaria parasite.

Pfander, Claudia; Anar, Burcu; Schwach, Frank; Otto, Thomas D; Brochet, Mathieu; Volkmann, Katrin; Quail, Michael A; Pain, Arnab; Rosen, Barry; Skarnes, William; Rayner, Julian C; Billker, Oliver.

Nat Methods; 8(12): 1078-82, 2011 Oct 23.

Artículo en Inglés | MEDLINE | ID: mdl-22020067

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