Acoustic far-field prediction based on near-field measurements by using several different holography algorithms.

Near-field acoustical holography (NAH) is a useful tool for sound field reconstruction and sound source identification. In NAH, a basis model is first selected to represent the physical sound field, and then a near-field measurement is made with a microphone array. Next, the parameters in the selected model can be estimated based on the measurements by using an inverse approach, resulting in the sound field near the source being reconstructed so that the sound source location can be identified. But, in addition to being able to reconstruct the near-field of a source, the far-field can also be predicted with the identified sound source model. A significant amount of work has been performed to study the near-field reconstruction capability of different NAH algorithms, but there has been a limited number of publications in which the far-field prediction accuracy, based on the near-field measurement constructed model, has been considered. In the present experimental work, two multi-transducer loudspeakers were placed side-by-side to create a multi-component sound source, and two sets of measurements were conducted: an intensity probe scanned the sound field generated by the loudspeakers in both the near-field (0.05 m) and far-field (0.48 m) such that the true near- and far-field intensity spatial distributions and total sound power could be identified. Then, based on the near-field pressure measurements, four acoustical holography algorithms, statistically optimized near-field acoustical holography, wideband acoustical holography, l1-norm minimization, and a hybrid compressive sampling method were used to predict the near- and far-field sound intensity distributions. The near- and far-field prediction results were compared with the direct measurement, and the sound field reconstruction accuracy was studied. It was found that all of the algorithms were able to reconstruct the near-field well when the near-field measurements were used to construct the model. It was found that with the abovementioned models, far-field reconstructions could correctly predict the spatial sound field distribution, but in all of the cases, the total sound power was underestimated.

An iterative transfer matrix approach for estimating the sound speed and attenuation constant of air in a standing wave tube.

In this work, an iterative method based on the four-microphone transfer matrix approach was developed for evaluating the sound speed and attenuation constant of air within a standing wave tube. When the air inside the standing wave tube is treated as the material under test, i.e., as if it were a sample of porous material, the transfer matrix approach can be used to identify the air's acoustic properties. The wavenumber within the tube is complex owing to the formation of a visco-thermal boundary layer on the inner circumference of the tube. Starting from an assumed knowledge of the air properties, an iterative method can be applied in the post-processing stage to estimate the complex wavenumber. Experimental results presented here show that although the results are sensitive to ambient temperature, a semi-empirical formula previously proposed by Temkin [(1981). Elements of Acoustics (John Wiley & Sons)] matches closely with the measured sound speed and attenuation constant, as does a theoretical formulation proposed by Lahiri et al. [(2014). J. Sound Vib. 333(15), 3440-3458]. Further, it is shown that the Temkin [(1981). Elements of Acoustics (John Wiley & Sons)] and Lahiri et al. [(2014). J. Sound Vib. 333(15), 3440-3458] predictions accurately represent the variation of sound speed with frequency, in contrast to the formula recommended in the ASTM E1050 standard [(2019). American Society for Testing and Materials], in which the sound speed is assumed to be independent of frequency.

The acoustical absorption by air-saturated aerogel powders.

The acoustical behavior of air-saturated aerogel powders in the audible frequency range is not well understood. It is not clear, for example, which physical processes control the acoustic absorption and/or attenuation in a very light, loose granular mix in which the grain diameter is on the order of a micron. The originality of this work is the use of a Biot-type poro-elastic model to fit accurately the measured absorption coefficients of two aerogel powders with particle diameters in the range 1-40 µm. It is shown that these materials behave like a viscoelastic layer and their absorption coefficient depends strongly on the root mean square sound pressure in the incident wave. Furthermore, it was found that the loss factor controlling the energy dissipation due to the vibration of the elastic frame is a key model parameter. The value of this parameter decreased progressively with the frequency and sound pressure. In contrast, other fitted parameters in the Biot-type poro-elastic model, e.g., the stiffness of the elastic frame and pore size, were found to be relatively independent of the frequency and amplitude of the incident wave. It is shown that these materials absorb acoustic waves very efficiently around the frequencies of the frame resonance.

Timing of HPV16-E6 antibody seroconversion before OPSCC: findings from the HPVC3 consortium.

BACKGROUND: Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown. PATIENTS AND METHODS: We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and Australia. In total, 743 incident OPSCC cases and 5814 controls provided at least one pre-diagnostic blood sample, including 111 cases with multiple samples. Median time between first blood collection and OPSCC diagnosis was 11.4 years (IQR = 6-11 years, range = 0-40 years). Antibodies against HPV16-E6 were measured by multiplex serology (GST fusion protein based Luminex assay). RESULTS: HPV16-E6 seropositivity was present in 0.4% of controls (22/5814; 95% CI 0.2% to 0.6%) and 26.2% (195/743; 95% CI 23.1% to 29.6%) of OPSCC cases. HPV16-E6 seropositivity increased the odds of OPSCC 98.2-fold (95% CI 62.1-155.4) in whites and 17.2-fold (95% CI 1.7-170.5) in blacks. Seropositivity in cases was more frequent in recent calendar periods, ranging from 21.9% pre-1996 to 68.4% in 2005 onwards, in those with blood collection near diagnosis (lead time <5 years). HPV16-E6 seropositivity increased with lead time: 0.0%, 13.5%, 23.7%, and 38.9% with lead times of >30 years (N = 24), 20-30 years (N = 148), 10-20 years (N = 228), and <10 years (N = 301 cases) (p-trend < 0.001). Of the 47 HPV16-E6 seropositive cases with serially-collected blood samples, 17 cases seroconverted during follow-up, with timing ranging from 6 to 28 years before diagnosis. For the remaining 30 cases, robust seropositivity was observed up to 25 years before diagnosis. CONCLUSIONS: The immune response to HPV16-driven tumorigenesis is most often detectable several decades before OPSCC diagnosis. HPV16-E6 seropositive individuals face increased risk of OPSCC over several decades.

Arthritis in adults, socioeconomic factors, and the moderating role of childhood maltreatment: cross-sectional data from the National Epidemiological Survey on Alcohol and Related Conditions.

These data present associations between socioeconomic status (SES), different types of childhood maltreatment (CM) history and family dysfunction, and arthritis in men and women across a wide age range. Arthritis was less likely among those with higher SES, regardless of CM history. INTRODUCTION: CM has been associated with increased risk of adult-onset arthritis; however, little is known about whether socioeconomic status moderates arthritis risk in those with CM history. We investigated arthritis across education, income, and race/ethnicity and whether CM moderated associations between SES and arthritis. METHODS: Data were drawn from Wave 2 (2004-2005) of the nationally representative (USA) National Epidemiological Survey on Alcohol and Related Conditions (NESARC, n = 34,563; aged ≥ 20 years). Self-reported CM history included physical abuse, sexual abuse, emotional abuse, emotional neglect, physical neglect, and exposure to intimate partner violence (IPV). We used descriptive statistics and logistic regression to determine relationships between SES, CM, and arthritis. Interaction terms were used to test if CM moderated relationships between SES and arthritis. RESULTS: Arthritis prevalence was 21.1% (n = 3093) among men and 30.1% (n = 6167) among women. In unadjusted analyses, women (p ≤ 0.001) and older age (both sexes, p ≤ 0.01) were associated with increased odds of arthritis. All CM types were associated with increased odds of arthritis, except exposure to IPV among women. In sex-stratified, age-adjusted analyses, lower education and income, family dysfunction, being Hispanic or Asian/Native Hawaiian/Pacific Islander, and ≥ 1 physical comorbidity were associated with increased odds of arthritis among those with and without CM: trends were similar for both sexes. In age-adjusted two-way interaction terms, CM did not moderate associations between SES and arthritis. CONCLUSIONS: Although CM was associated with arthritis, associations between SES and arthritis were not amplified. Arthritis was less likely among those with higher SES, regardless of CM history.

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience.

Resilience to stress-related emotional disorders is governed in part by early-life experiences. Here we demonstrate experience-dependent re-programming of stress-sensitive hypothalamic neurons, which takes place through modification of neuronal gene expression via epigenetic mechanisms. Specifically, we found that augmented maternal care reduced glutamatergic synapses onto stress-sensitive hypothalamic neurons and repressed expression of the stress-responsive gene, Crh. In hypothalamus in vitro, reduced glutamatergic neurotransmission recapitulated the repressive effects of augmented maternal care on Crh, and this required recruitment of the transcriptional repressor repressor element-1 silencing transcription factor/neuron restrictive silencing factor (NRSF). Increased NRSF binding to chromatin was accompanied by sequential repressive epigenetic changes which outlasted NRSF binding. chromatin immunoprecipitation-seq analyses of NRSF targets identified gene networks that, in addition to Crh, likely contributed to the augmented care-induced phenotype, including diminished depression-like and anxiety-like behaviors. Together, we believe these findings provide the first causal link between enriched neonatal experience, synaptic refinement and induction of epigenetic processes within specific neurons. They uncover a novel mechanistic pathway from neonatal environment to emotional resilience.

Spatially sparse sound source localization in an under-determined system by using a hybrid compressive sensing method.

Near-field Acoustical Holography is a powerful tool for sound source identification and sound field reconstruction. Generally, many microphone measurements are required to construct a source model that can span the whole sound source region while simultaneously avoiding measurement errors and ensuring a high spatial sampling rate. That type of measurement is economically costly and hard to perform in industrial environments. Motivated by the desire to be able to use a relatively small number of microphone measurements to reconstruct a sound field and to accurately identify sound source locations, an Equivalent Source Method (ESM) is considered here. In particular, the focus is on the combination of a monopole-distribution ESM and a relatively small number of microphone measurements, thus creating an under-determined system. Wideband Acoustical Holography and l1-norm Convex Optimization are introduced to solve this under-determined inverse problem. Based on the attributes of these two methods, a hybrid method combining the best features of each is proposed to identify sound source locations.

Calculation of acoustic radiation modes by using spherical waves and generalized singular value decomposition.

Acoustic radiation modes (ARMs) have been widely used in noise control engineering owing to their convenient sound-power characteristics. However, the evaluation of ARMs for non-regular structures can be computationally intensive: it usually involves solving the boundary integral equation (BIE) by using the boundary element method in order to obtain the sound power radiation resistance matrix, followed by a singular value decomposition to obtain the radiation modes. The proposed procedure involves projecting spherical harmonics onto an enclosing surface, followed by the application of generalized singular value decomposition, with the result that the need to solve the BIE is eliminated, which potentially reduces the computational effort significantly.

Microstructure design of lightweight fibrous material acting as a layered damper for a vibrating stiff panel.

Based on the idea that a layer of properly designed and manufactured fibrous material can serve as both a sound absorber and a structural damper, an approach is introduced in this article to design the microstructure of a fibrous layer for it to provide optimal damping performance. To begin with, previous work related to structural damping by fibrous layers was reviewed. Then the most appropriate models from the literature were adapted for use in the current study. A system comprising an aluminum panel and a limp fibrous layer was driven by a line force, and both the spatial velocity response of the panel and the power distribution within the system were calculated to quantify the degree of damping provided by the fibrous layer, which helped identify the airflow resistivity that provides optimal damping for any frequency and panel of interest. Given the optimal airflow resistivity, a model relating fiber microstructure to airflow resistivity was used to infer the optimal microstructure required to achieve the optimal damping performance. One finding of the current work, for example, was that as the target frequency was reduced, the fiber size required to achieve the optimal damping performance increased.

Sound field reconstruction using multipole equivalent source model with un-fixed source locations.

The equivalent source methods (ESM) that have been developed to this point can generally be classified into two categories: one in which a relatively large number of lower order sources are fixed at various locations, and one in which a series of higher order sources are fixed at one location. The present work started with a model in the latter category, but the individual sources were then allowed to move separately to locations which were determined by using a nonlinear optimization procedure based on the measured sound field data. To test this approach, experiments were conducted using a small loudspeaker cabinet; measurements were made using an array of microphones on all sides of the loudspeaker. It was found that by allowing the source components to move, the sound field representation in both the near and far fields was improved, particularly at high frequencies, compared to the model with fixed source locations. By comparison with results obtained from boundary element calculations based on laser vibrometer measurements of the loudspeaker's diaphragm and tweeter velocities, it was found that the proposed ESM can also be used to accurately predict the sound pressure distribution on the source surface.

Experiments on the low frequency barrier characteristics of cellular metamaterial panels in a diffuse sound field.

The metamaterial under investigation here consists of a periodic arrangement of unit plates in a grid-like frame such that there is a contrast in the local areal mass between cell interior and cell wall. In the low frequency range and under normal incidence this metamaterial panel exhibits a sound transmission loss significantly larger than the transmission loss of an unstructured panel with the same homogeneous mass per unit area. However, when the incident sound field is diffuse, the relative advantage of the metamaterial barrier is reduced or eliminated. A sequence of experiments is documented to demonstrate that the relative advantage of the metamaterial barrier can be realized even in a diffuse sound field by creating a hybrid barrier system which embeds the metamaterial layer between a normalizing waveguide layer on the incident side and an absorbing layer on the transmitted side. The sound normalizing waveguide layer is a lattice structure, and the absorbing layer is high performance glass fiber mat. By using measurements of the transmission loss of a 1.2 m square panel system the role of each of these components is demonstrated.

Bounded inhomogeneous wave profiles for increased surface wave excitation efficiency at fluid-solid interfaces.

Though the ultrasonic excitation of surface waves in solids is generally realized through the use of a contact transducer, remote excitation would enable standoff testing in applications such as the nondestructive evaluation of structures. With respect to the optimal incident wave profile, bounded inhomogeneous waves, which include an exponentially decaying term, have been shown to improve the surface wave excitation efficiency as compared to Gaussian and square waves. The purpose of this work is to investigate the effect of varying the incident wave spatial decay rate, as applied to both lossless fluid-solid interfaces and to solids with viscoelastic losses included. The Fourier method is used to decompose the incident profile and subsequently compute the reflected wave profile. It is shown that inhomogeneous plane wave theory predicts, to a close approximation, the location of the minimum in the local reflection coefficient with respect to the decay rate for bounded incident waves. Moreover, plane wave theory gives a reasonable indication of the decay rate that maximizes the surface wave excitation efficiency.

On the completeness and the linear dependence of the Cartesian multipole series in representing the solution to the Helmholtz equation.

The (Cartesian) multipole series, i.e., the series comprising monopole, dipoles, quadrupoles, etc., can be used, as an alternative to the spherical or cylindrical wave series, in representing sound fields in a wide range of problems, such as source radiation, sound scattering, etc. The proofs of the completeness of the spherical and cylindrical wave series in these problems are classical results, and it is also generally agreed that the Cartesian multipole series spans the same space as the spherical waves: a rigorous mathematical proof of that statement has, however, not been presented. In the present work, such a proof of the completeness of the Cartesian multipole series, both in two and three dimensions, is given, and the linear dependence relations among different orders of multipoles are discussed, which then allows one to easily extract a basis from the multipole series. In particular, it is concluded that the multipoles comprising the two highest orders in the series form a basis of the whole series, since the multipoles of all the lower source orders can be expressed as a linear combination of that basis.

Risk of suicide and suicide attempts associated with physical disorders: a population-based, balancing score-matched analysis.

BACKGROUND: The association between physical disorders and suicide remains unclear. The aim of this study was to examine the relationship between physical disorders and suicide after accounting for the effects of mental disorders. METHOD: Individuals who died by suicide (n = 2100) between 1996 and 2009 were matched 3:1 by balancing score to general population controls (n = 6300). Multivariate conditional logistic regression compared the two groups across physician-diagnosed physical disorders [asthma, chronic obstructive pulmonary disease (COPD), ischemic heart disease, hypertension, diabetes, cancer, multiple sclerosis and inflammatory bowel disease], adjusting for mental disorders and co-morbidity. Secondary analyses examined the risk of suicide according to time since first diagnosis of each physical disorder (1-90, 91-364, ⩾ 365 days). Similar analyses also compared individuals with suicide attempts (n = 8641) to matched controls (n = 25 923). RESULTS: Cancer was associated with increased risk of suicide [adjusted odds ratio (AOR) 1.40, 95% confidence interval (CI) 1.03-1.91, p < 0.05] even after adjusting for all mental disorders. The risk of suicide with cancer was particularly high in the first 90 days after initial diagnosis (AOR 4.10, 95% CI 1.71-9.82, p < 0.01) and decreased to non-significance after 1 year. Women with respiratory diseases had elevated risk of suicide whereas men did not. COPD, hypertension and diabetes were each associated with increased odds of suicide attempts in adjusted models (AORs ranged from 1.20 to 1.73). CONCLUSIONS: People diagnosed with cancer are at increased risk of suicide, especially in the 3 months following initial diagnosis. Increased support and psychiatric involvement should be considered for the first year after cancer diagnosis.

On the use of evanescent plane waves for low-frequency energy transmission across material interfaces.

The transmission of airborne sound into high-impedance media is of interest in several applications. For example, sonic booms in the atmosphere may impact marine life when incident on the ocean surface, or affect the integrity of existing structures when incident on the ground. Transmission across high impedance-difference interfaces is generally limited by reflection and refraction at the surface, and by the critical angle criterion. However, spatially decaying incident waves, i.e., inhomogeneous or evanescent plane waves, may transmit energy above the critical angle, unlike homogeneous plane waves. The introduction of a decaying component to the incident trace wavenumber creates a nonzero propagating component of the transmitted normal wavenumber, so energy can be transmitted across the interface. A model of evanescent plane waves and their transmission across fluid-fluid and fluid-solid interfaces is developed here. Results are presented for both air-water and air-solid interfaces. The effects of the incident wave parameters (including the frequency, decay rate, and incidence angle) and the interfacial properties are investigated. Conditions for which there is no reflection at the air-solid interface, due to impedance matching between the incident and transmitted waves, are also considered and are found to yield substantial transmission increases over homogeneous incident waves.

Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies.

BACKGROUND: Associations between circulating concentrations of oestrogens, progesterone, and androgens with breast cancer and related risk factors in premenopausal women are not well understood. We aimed to characterise these associations with a pooled analysis of data from seven studies. METHODS: Individual participant data for prediagnostic sex hormone and sex hormone-binding globulin (SHBG) concentrations were contributed from seven prospective studies. We restricted analyses to women who were premenopausal and younger than 50 years at blood collection, and to women with breast cancer diagnosed before age 50 years. We estimated odds ratios (ORs) with 95% CIs for breast cancer associated with hormone concentrations by conditional logistic regression in cases and controls matched for age, date of blood collection, and day of cycle, with stratification by study and further adjustment for cycle phase. We examined associations of hormones with risk factors for breast cancer in control women by comparing geometric mean hormone concentrations in categories of these risk factors, adjusted for study, age, phase of menstrual cycle, and body-mass index (BMI). All statistical tests were two-sided. FINDINGS: We included data for up to 767 women with breast cancer and 1699 controls in the risk analyses. Breast cancer risk was associated with a doubling in concentrations of oestradiol (OR 1·19, 95% CI 1·06-1·35), calculated free oestradiol (1·17, 1·03-1·33), oestrone (1·27, 1·05-1·54), androstenedione (1·30, 1·10-1·55), dehydroepiandrosterone sulphate (1·17, 1·04-1·32), testosterone (1·18, 1·03-1·35), and calculated free testosterone (1·08, 0·97-1·21). Breast cancer risk was not associated with luteal phase progesterone (doubling in concentration OR 1·00, 95% CI 0·92-1·09), and adjustment for other factors had little effect on any of these ORs. Cross-sectional analyses in control women showed several associations of sex hormones with breast cancer risk factors. INTERPRETATION: Circulating oestrogens and androgens are positively associated with the risk for breast cancer in premenopausal women.

Reconstruction of the free-field radiation from a vibrating structure based on measurements in a noisy environment.

In a noisy environment, the sound field of a source is composed of three parts, which are: The field that would be radiated by the target source into free space, the incoming field from disturbing sources or reflections, and the scattered field that is created by the incoming wave falling on the target source. To accurately identify the sound source with nearfield acoustic holography in that situation, the last two parts must be removed from the mixed field. In a previous study, a method for recovering the free sound field in a noisy environment was proposed based on the equivalent source method and measurements of pressure [J. Acoust. Soc. Am. 131(2), 1260-1270 (2012)]. In the present paper, that method was modified by allowing the input data to be measurements of particle velocity instead of pressure. An experiment was carried out to examine both the pressure- and velocity-based methods, and the performance of the two methods was compared. It was found that both methods are capable of reconstructing the free-field pressure radiated by the target source based on measurements made in a noisy environment, but the velocity-based method shows a large benefit in the reconstruction of the free-field particle velocity.

Transfer impedance of microperforated materials with tapered holes.

It has been previously shown that relatively simple computational fluid dynamics (CFD) models can be used to calculate the transfer impedances, including the associated end corrections, of microperforated panels. The impedance is estimated by first calculating the pressure difference across a single hole when a transient input velocity is imposed, and then Fourier transforming the result to obtain the impedance as a function of frequency. Since the size of the hole and the dimensions of the inlet and outlet channels are very small compared to a wavelength, the flow through the hole can be modeled as incompressible. By using those procedures, Bolton and Kim extended Maa's classical theory to include a resistive end correction for sharp-edged cylindrical holes which differs from those previously proposed by the inclusion of a static component. Here it is shown that CFD models can also be used to compute end corrections for tapered holes. Since practical experimental characterization of perforated materials often involves measurement of the static flow resistance, a closed form empirical equation for that quantity has been developed. Finally, it is shown that configurations having equivalent static flow resistances can yield different acoustic absorptions.

An equivalent source technique for recovering the free sound field in a noisy environment.

In previous studies, a sound field separation technique based on the equivalent source method (ESM) was successfully applied to separate the incoming and outgoing fields composing a non-free field. However, if the incoming wave is scattered by the source surface, the outgoing field is not the field that would be generated by the source in a free field. The object of the present work was to provide an equivalent source technique that allows the recovery of that free field in a noisy environment. In this approach, the incoming and outgoing fields, including the scattered and directly radiated fields on the measurement surface, are separated to obtain the free-field pressure that would be radiated by the source in an anechoic environment. The recovered free-field pressure is then used to reconstruct the whole free field of the source by using near-field acoustical holography based on the ESM, which makes the results equivalent to those that could be obtained from a free-field measurement. A theoretical description of the technique is given first, and then three numerical cases are investigated to demonstrate the ability of the proposed method.

Loss of a globally unique kelp forest from Oman.

Kelp forests are declining in many regions globally with climatic perturbations causing shifts to alternate communities and significant ecological and economic loss. Range edge populations are often at most risk and are often only sustained through localised areas of upwelling or on deeper reefs. Here we document the loss of kelp forests (Ecklonia radiata) from the Sultanate of Oman, the only confirmed northern hemisphere population of this species. Contemporary surveys failed to find any kelp in its only known historical northern hemisphere location, Sadah on the Dhofar coast. Genetic analyses of historical herbarium specimens from Oman confirmed the species to be E. radiata and revealed the lost population contained a common CO1 haplotype found across South Africa, Australia and New Zealand suggesting it once established through rapid colonisation throughout its range. However, the Omani population also contained a haplotype that is found nowhere else in the extant southern hemisphere distribution of E. radiata. The loss of the Oman population could be due to significant increases in the Arabian Sea temperature over the past 40 years punctuated by suppression of coastal upwelling. Climate-mediated warming is threatening the persistence of temperate species and precipitating loss of unique genetic diversity at lower latitudes.