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1.

The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium.

Bonser, Luke R; Eckalbar, Walter L; Rodriguez, Lauren; Shen, Jiangshan; Koh, Kyung Duk; Ghias, Khadija; Zlock, Lorna T; Christenson, Stephanie; Woodruff, Prescott G; Finkbeiner, Walter E; Erle, David J.

Am J Respir Cell Mol Biol; 66(4): 391-401, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-34982656

2.

Flow-Cytometric Analysis and Purification of Airway Epithelial-Cell Subsets.

Bonser, Luke R; Koh, Kyung Duk; Johansson, Kristina; Choksi, Semil P; Cheng, Dan; Liu, Leqian; Sun, Dingyuan I; Zlock, Lorna T; Eckalbar, Walter L; Finkbeiner, Walter E; Erle, David J.

Am J Respir Cell Mol Biol; 64(3): 308-317, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33196316

3.

Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.

Lee, Eunice Y; Mak, Angel C Y; Hu, Donglei; Sajuthi, Satria; White, Marquitta J; Keys, Kevin L; Eckalbar, Walter; Bonser, Luke; Huntsman, Scott; Urbanek, Cydney; Eng, Celeste; Jain, Deepti; Abecasis, Gonçalo; Kang, Hyun M; Germer, Soren; Zody, Michael C; Nickerson, Deborah A; Erle, David; Ziv, Elad; Rodriguez-Santana, Jose; Seibold, Max A; Burchard, Esteban G.

Am J Respir Crit Care Med; 202(7): 962-972, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-32459537

4.

Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.

Koh, Kyung Duk; Siddiqui, Sana; Cheng, Dan; Bonser, Luke R; Sun, Dingyuan I; Zlock, Lorna T; Finkbeiner, Walter E; Woodruff, Prescott G; Erle, David J.

Am J Respir Cell Mol Biol; 62(3): 373-381, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31596609

5.

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

Bhakta, Nirav R; Christenson, Stephanie A; Nerella, Srilaxmi; Solberg, Owen D; Nguyen, Christine P; Choy, David F; Jung, Kyle L; Garudadri, Suresh; Bonser, Luke R; Pollack, Joshua L; Zlock, Lorna T; Erle, David J; Langelier, Charles; Derisi, Joseph L; Arron, Joseph R; Fahy, John V; Woodruff, Prescott G.

Am J Respir Crit Care Med; 197(3): 313-324, 2018 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-29064281

6.

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.

Bonser, Luke R; Schroeder, Bradley W; Ostrin, Lisa A; Baumlin, Nathalie; Olson, Jean L; Salathe, Matthias; Erle, David J.

Am J Respir Cell Mol Biol; 53(4): 536-43, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-25751668

7.

Putting Mucins on the Map.

Bonser, Luke R; Erle, David J.

Am J Respir Crit Care Med; 199(6): 681-682, 2019 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-30376352

8.

Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.

Cheng, Dan; Xue, Zheng; Yi, Lingling; Shi, Huimin; Zhang, Kan; Huo, Xiaorong; Bonser, Luke R; Zhao, Jianping; Xu, Yongjian; Erle, David J; Zhen, Guohua.

Am J Respir Crit Care Med; 190(6): 639-48, 2014 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-25133876

9.

Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma.

Koh, Kyung Duk; Bonser, Luke R; Eckalbar, Walter L; Yizhar-Barnea, Ofer; Shen, Jiangshan; Zeng, Xiaoning; Hargett, Kirsten L; Sun, Dingyuan I; Zlock, Lorna T; Finkbeiner, Walter E; Ahituv, Nadav; Erle, David J.

Cell Genom; 3(1): 100229, 2023 Jan 11.

Artículo en Inglés | MEDLINE | ID: mdl-36777184

10.

Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2.

Yang, Junjiao; Xiao, Yinghong; Lidsky, Peter V; Wu, Chien-Ting; Bonser, Luke R; Peng, Shiming; Garcia-Knight, Miguel A; Tassetto, Michel; Chung, Chan-I; Li, Xiaoquan; Nakayama, Tsuguhisa; Lee, Ivan T; Nayak, Jayakar V; Ghias, Khadija; Hargett, Kirsten L; Shoichet, Brian K; Erle, David J; Jackson, Peter K; Andino, Raul; Shu, Xiaokun.

Nat Microbiol; 8(1): 121-134, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36604514

11.

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.

Hysenaj, Lisiena; Little, Samantha; Kulhanek, Kayla; Magnen, Melia; Bahl, Kriti; Gbenedio, Oghenekevwe M; Prinz, Morgan; Rodriguez, Lauren; Andersen, Christopher; Rao, Arjun Arkal; Shen, Alan; Lone, Jean-Christophe; Lupin-Jimenez, Leonard C; Bonser, Luke R; Serwas, Nina K; Mick, Eran; Khalid, Mir M; Taha, Taha Y; Kumar, Renuka; Li, Jack Z; Ding, Vivianne W; Matsumoto, Shotaro; Maishan, Mazharul; Sreekumar, Bharath; Simoneau, Camille; Nazarenko, Irina; Tomlinson, Michael G; Khan, Khajida; von Gottberg, Anne; Sigal, Alex; Looney, Mark R; Fragiadakis, Gabriela K; Jablons, David M; Langelier, Charles R; Matthay, Michael; Krummel, Matthew; Erle, David J; Combes, Alexis J; Sil, Anita; Ott, Melanie; Kratz, Johannes R; Roose, Jeroen P.

Stem Cell Reports; 18(3): 636-653, 2023 03 14.

Artículo en Inglés | MEDLINE | ID: mdl-36827975

12.

The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.

Bonser, Luke R; Eckalbar, Walter L; Rodriguez, Lauren; Shen, Jiangshan; Koh, Kyung Duk; Zlock, Lorna T; Christenson, Stephanie; Woodruff, Prescott G; Finkbeiner, Walter E; Erle, David J.

bioRxiv; 2021 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-33655249

13.

Epithelial miR-141 regulates IL-13-induced airway mucus production.

Siddiqui, Sana; Johansson, Kristina; Joo, Alex; Bonser, Luke R; Koh, Kyung Duk; Le Tonqueze, Olivier; Bolourchi, Samaneh; Bautista, Rodriel A; Zlock, Lorna; Roth, Theodore L; Marson, Alexander; Bhakta, Nirav R; Ansel, K Mark; Finkbeiner, Walter E; Erle, David J; Woodruff, Prescott G.

JCI Insight; 6(5)2021 03 08.

Artículo en Inglés | MEDLINE | ID: mdl-33682796

14.

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.

Hysenaj, Lisiena; Little, Samantha; Kulhanek, Kayla; Gbenedio, Oghenekevwe M; Rodriguez, Lauren; Shen, Alan; Lone, Jean-Christophe; Lupin-Jimenez, Leonard C; Bonser, Luke R; Serwas, Nina K; Bahl, Kriti; Mick, Eran; Li, Jack Z; Ding, Vivianne W; Matsumoto, Shotaro; Maishan, Mazharul; Simoneau, Camille; Fragiadakis, Gabriela; Jablons, David M; Langelier, Charles R; Matthay, Michael; Ott, Melanie; Krummel, Matthew; Combes, Alexis J; Sil, Anita; Erle, David J; Kratz, Johannes R; Roose, Jeroen P.

bioRxiv; 2021 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-34100012

15.

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Samuel, Ryan M; Majd, Homa; Richter, Mikayla N; Ghazizadeh, Zaniar; Zekavat, Seyedeh Maryam; Navickas, Albertas; Ramirez, Jonathan T; Asgharian, Hosseinali; Simoneau, Camille R; Bonser, Luke R; Koh, Kyung Duk; Garcia-Knight, Miguel; Tassetto, Michel; Sunshine, Sara; Farahvashi, Sina; Kalantari, Ali; Liu, Wei; Andino, Raul; Zhao, Hongyu; Natarajan, Pradeep; Erle, David J; Ott, Melanie; Goodarzi, Hani; Fattahi, Faranak.

Cell Stem Cell; 27(6): 876-889.e12, 2020 12 03.

Artículo en Inglés | MEDLINE | ID: mdl-33232663

16.

The airway epithelium in asthma.

Bonser, Luke R; Erle, David J.

Adv Immunol; 142: 1-34, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31296301

17.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson, Stephanie A; van den Berge, Maarten; Faiz, Alen; Inkamp, Kai; Bhakta, Nirav; Bonser, Luke R; Zlock, Lorna T; Barjaktarevic, Igor Z; Barr, R Graham; Bleecker, Eugene R; Boucher, Richard C; Bowler, Russell P; Comellas, Alejandro P; Curtis, Jeffrey L; Han, MeiLan K; Hansel, Nadia N; Hiemstra, Pieter S; Kaner, Robert J; Krishnanm, Jerry A; Martinez, Fernando J; O'Neal, Wanda K; Paine, Robert; Timens, Wim; Wells, J Michael; Spira, Avrum; Erle, David J; Woodruff, Prescott G.

J Clin Invest; 129(1): 169-181, 2019 01 02.

Artículo en Inglés | MEDLINE | ID: mdl-30383540

18.

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.

Bonser, Luke R; Erle, David J.

J Clin Med; 6(12)2017 Nov 29.

Artículo en Inglés | MEDLINE | ID: mdl-29186064

19.

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

Welsh, Kathryn G; Rousseau, Karine; Fisher, Gemma; Bonser, Luke R; Bradding, Peter; Brightling, Chris E; Thornton, David J; Gaillard, Erol A.

Chest; 152(4): 771-779, 2017 10.

Artículo en Inglés | MEDLINE | ID: mdl-28716644

20.

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.

Bonser, Luke R; Zlock, Lorna; Finkbeiner, Walter; Erle, David J.

J Clin Invest; 126(6): 2367-71, 2016 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-27183390

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The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium.

Flow-Cytometric Analysis and Purification of Airway Epithelial-Cell Subsets.

Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.

Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.

Putting Mucins on the Map.

Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.

Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma.

Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2.

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.

The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.

Epithelial miR-141 regulates IL-13-induced airway mucus production.

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

The airway epithelium in asthma.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.