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1.

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

Zheng, Yang; Schroeder, Susanne; Kanev, Georgi K; Botros, Sanaa S; William, Samia; Sabra, Abdel-Nasser A; Maes, Louis; Caljon, Guy; Gil, Carmen; Martinez, Ana; Salado, Irene G; Augustyns, Koen; Edink, Ewald; Sijm, Maarten; de Heuvel, Erik; de Esch, Iwan J P; van der Meer, Tiffany; Siderius, Marco; Sterk, Geert Jan; Brown, David; Leurs, Rob.

Int J Mol Sci; 24(7)2023 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-37047792

2.

The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo.

Botros, Sanaa S; El-Lakkany, Naglaa M; Seif El-Din, Sayed H; William, Samia; Sabra, Abdel-Nasser; Hammam, Olfat A; de Koning, Harry P.

Exp Parasitol; 208: 107793, 2020 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-31711973

3.

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools.

Sebastian-Perez, Victor; García-Rubia, Alfonso; Seif El-Din, Sayed H; Sabra, Abdel-Nasser A; El-Lakkany, Naglaa M; William, Samia; Blundell, Tom L; Maes, Louis; Martinez, Ana; Campillo, Nuria E; Botros, Sanaa S; Gil, Carmen.

J Enzyme Inhib Med Chem; 35(1): 511-523, 2020 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-31939312

4.

Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus.

El-Lakkany, Naglaa M; Hendawy, Ahmed S; Seif El-Din, Sayed H; Ashour, Ahmed A; Atta, Raafat; Abdel-Aziz, Abdel-Aziz H; Mansour, Ahmed M; Botros, Sanaa S.

Eur J Clin Pharmacol; 72(5): 573-82, 2016 May.

Artículo en Inglés | MEDLINE | ID: mdl-26888096

5.

Metabolic profile and hepatoprotective activity of the anthocyanin-rich extract of Hibiscus sabdariffa calyces.

Ezzat, Shahira M; Salama, Maha M; Seif El-Din, Sayed H; Saleh, Samira; El-Lakkany, Naglaa M; Hammam, Olfat A; Salem, Maha B; Botros, Sanaa S.

Pharm Biol; 54(12): 3172-3181, 2016 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-27564372

6.

Praziquantel in a clay nanoformulation shows more bioavailability and higher efficacy against murine Schistosoma mansoni infection.

El-Feky, Gina S; Mohamed, Wael S; Nasr, Hanaa E; El-Lakkany, Naglaa M; Seif El-Din, Sayed H; Botros, Sanaa S.

Antimicrob Agents Chemother; 59(6): 3501-8, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25845870

7.

Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice.

Seif el-Din, Sayed H; El-Lakkany, Naglaa M; Mohamed, Mona A; Hamed, Manal M; Sterner, Olov; Botros, Sanaa S.

Pharm Biol; 52(2): 144-50, 2014 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-24047470

8.

Vildagliptin alleviates liver fibrosis in NASH diabetic rats via modulation of insulin resistance, oxidative stress, and inflammatory cascades.

Hendawy, Ahmed S; El-Lakkany, Naglaa M; Mantawy, Eman M; Hammam, Olfat A; Botros, Sanaa S; El-Demerdash, Ebtehal.

Life Sci; 304: 120695, 2022 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-35671811

9.

Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways.

Ahmed, Lamiaa A; Salem, Maha B; Seif El-Din, Sayed H; El-Lakkany, Naglaa M; Ahmed, Hend O; Nasr, Sami M; Hammam, Olfat A; Botros, Sanaa S; Saleh, Samira.

Eur J Pharmacol; 887: 173461, 2020 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-32758573

10.

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.

Munday, Jane C; Kunz, Stefan; Kalejaiye, Titilola D; Siderius, Marco; Schroeder, Susanne; Paape, Daniel; Alghamdi, Ali H; Abbasi, Zainab; Huang, Sheng Xiang; Donachie, Anne-Marie; William, Samia; Sabra, Abdel Nasser; Sterk, Geert Jan; Botros, Sanaa S; Brown, David G; Hoffman, Charles S; Leurs, Rob; de Koning, Harry P.

PLoS Negl Trop Dis; 14(7): e0008447, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32730343

11.

Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.

Botros, Sanaa S; William, Samia; Beadle, James R; Valiaeva, Nadejda; Hostetler, Karl Y.

Antimicrob Agents Chemother; 53(12): 5284-7, 2009 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-19704122

12.

Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study.

El-Lakkany, Naglaa M; El-Maadawy, Walaa H; Seif El-Din, Sayed H; Saleh, Samira; Safar, Marwa M; Ezzat, Shahira M; Mohamed, Salwa H; Botros, Sanaa S; Demerdash, Zeinab; Hammam, Olfat A.

J Tradit Complement Med; 9(1): 45-53, 2019 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-30671365

13.

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.

Botros, Sanaa S; William, Samia; Sabra, Abdel-Nasser A; El-Lakkany, Naglaa M; Seif El-Din, Sayed H; García-Rubia, Alfonso; Sebastián-Pérez, Victor; Blaazer, Antoni R; de Heuvel, Erik; Sijm, Maarten; Zheng, Yang; Salado, Irene G; Munday, Jane C; Maes, Louis; de Esch, Iwan J P; Sterk, Geert J; Augustyns, Koen; Leurs, Rob; Gil, Carmen; De Koning, Harry P.

Int J Parasitol Drugs Drug Resist; 9: 35-43, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30669086

14.

Response of Schistosoma mansoni isolates having different drug sensitivity to praziquantel over several life cycle passages with and without therapeutic pressure.

Sabra, Abdel Nasser A; Botros, Sanaa S.

J Parasitol; 94(2): 537-41, 2008 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-18564758

15.

Drug-metabolizing enzymes and praziquantel bioavailability in mice harboring Schistosoma mansoni isolates of different drug susceptibilities.

Botros, Sanaa S; El-Din, Sayed H Seif; El-Lakkany, Naglaa M; Sabra, Abdel Nasser A; Ebeid, Fatma A.

J Parasitol; 92(6): 1344-9, 2006 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-17304818

16.

Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates.

Cioli, Donato; Botros, Sanaa S; Wheatcroft-Francklow, Katherine; Mbaye, Amadou; Southgate, Vaughan; Tchuenté, Louis-Albert Tchuem; Pica-Mattoccia, Livia; Troiani, Anna Rita; El-Din, Sayed H Seif; Sabra, Abdel-Nasser A; Albin, Jan; Engels, Dirk; Doenhoff, Michael J.

Int J Parasitol; 34(8): 979-87, 2004 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-15217737

17.

A model for Southern Mediterranean research institute self-assessment: a SWOT analysis-based approach to promote capacity building at Theodor Bilharz Research Institute in Cairo (Egypt).

Ghinolfi, Davide; El Baz, Hanan G; Borgonovi, Elio; Radwan, Amr; Laurence, Ola; Sayed, Hanan A; De Simone, Paolo; Abdelwadoud, Moaz; Stefani, Alessandro; Botros, Sanaa S; Filipponi, Franco.

Arab J Gastroenterol; 15(3-4): 92-7, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-25241620

18.

Praziquantel efficacy in mice infected with PZQ non-susceptible S. mansoni isolate treated with artemether: parasitological, biochemical and immunohistochemical assessment.

Botros, Sanaa S; Hammam, Olfat; Mahmoud, Madiha; Bergquist, Robert.

APMIS; 118(9): 692-702, 2010 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-20718722

19.

Praziquantel resistance.

Botros, Sanaa S; Bennett, James L.

Expert Opin Drug Discov; 2(s1): S35-40, 2007 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-23489031

20.

Immunohistopathological and biochemical changes in Schistosoma mansoni-infected mice treated with artemether.

Botros, Sanaa S; Mahmoud, Madiha R; Moussa, Mona M; Nosseir, Mona M.

J Infect; 55(5): 470-7, 2007 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-17868901

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