RESUMEN
The influence of pure virus solution on wound healing was studied in animals. The rate of disturbed wound healing was proportional to the concentration of the virus solution. Severe necrosis without inflammatory reaction could be demonstrated histologically.
Asunto(s)
Virosis/complicaciones , Cicatrización de Heridas , Heridas y Lesiones/microbiología , Animales , Bovinos , Cobayas , Ratones , Necrosis/microbiología , ConejosAsunto(s)
Feto , Jugo Gástrico/metabolismo , Gastrinas/metabolismo , Histamina/metabolismo , Insulina/metabolismo , Intercambio Materno-Fetal , Animales , Cloruros/análisis , Perros , Femenino , Determinación de la Acidez Gástrica , Jugo Gástrico/análisis , Gastrinas/farmacología , Histamina/farmacología , Insulina/farmacología , Potasio/análisis , Embarazo , Estimulación QuímicaAsunto(s)
Clorpromazina , Trasplante de Hígado , Fenoxibenzamina , Conservación de Tejido , Fosfatasa Ácida/sangre , Fosfatasa Ácida/metabolismo , Alanina Transaminasa/sangre , Animales , Cortisona , Perros , Glucuronidasa/sangre , Glucuronidasa/metabolismo , Hígado/enzimología , Lisosomas , Membranas , Métodos , Nefrectomía , Trasplante HomólogoAsunto(s)
Fosfatasa Ácida/sangre , Alanina Transaminasa/sangre , Fosfatasa Alcalina/sangre , Aspartato Aminotransferasas/sangre , Glucuronidasa/sangre , Trasplante de Hígado , Conservación de Tejido , Animales , Biopsia , Retículo Endoplásmico , Haplorrinos , Hígado/citología , Circulación Hepática , Metilprednisolona/farmacología , Microscopía Electrónica , Mitocondrias Hepáticas/citología , Fenoxibenzamina/farmacología , Factores de TiempoRESUMEN
The reactions of connective tissue and fibers to silk, catgut, chromic catgut and polyglucolic acid fibers buried in the subcutis and to which a solution of vaccinia (WHO Elstree strain) or a control solution was added, were tested in 7 rabbits. Of the fibers tested, the histological picture on the 9th postoperative day showed that polygluconic acid fibers were by far the best, catgut fibers were particularly poor.
Asunto(s)
Suturas , Cicatrización de Heridas , Animales , Catgut , Ácido Poliglicólico , Conejos , Virus VacciniaRESUMEN
During the last 12 years, 1489 vagotomies were performed at the Chirurgische Poliklinik of Munich University; 1339 of them were selective proximal vagotomies (SPV). The main indication was duodenal ulcer (n = 915) and gastric ulcer (n = 188), including emergency operations for extensive bleeding. Further indications were: sliding hiatal hernia, erosive gastritis and achalasia of the cardia. The SPA was combined in all cases with a pyloroplasty based on form and function. The results are shown in detail related to mortality (elective 0.5%), recurrency (1.6%) and functional results (good 88.2%, fair 7.2%, poor 4.6%). The combined operation of SPV with pyloroplasty is, in our opinion, an operative procedure which allows non resectioning surgical treatment of GDU without selection, i.e. based on form and function.
Asunto(s)
Úlcera Duodenal/cirugía , Úlcera Gástrica/cirugía , Enfermedad Aguda , Drenaje , Gastritis/cirugía , Hernia Hiatal/cirugía , Humanos , Úlcera Péptica Hemorrágica/cirugía , Píloro/cirugía , Recurrencia , Estudios Retrospectivos , Vagotomía/métodos , Vagotomía/mortalidadRESUMEN
In 21 mongrel dogs blood flow was measured in different gastrointestinal organs under fasting conditions, vagal stimulation with 2-desoxy-D-glucose and vagotomy. The examinations were performed in anaesthesia with the microsphere method. Basal blood flow was found in corpus, fundus and antrum below 0,5 ml/g X min, whereas in the region of the small curvature values of 0,7 ml/g X min were observed. Vagotomy decreases flowrates especially in the mucosa of the stomach except in the region of the antrum. There a significant increase was measured. The stimulated bloodflow shows a similar effect by a vagotomy, but on an elevated lovel. Observations over the time of 3 weeks revealed that bloodflow changes due to vagotomy are not long lasting over that time. Only a decrease can be observed in the region of the antrum. Also in the other abdominal organs bloodflow changes due to vagotomy are terminated to a short time interval. Except the bloodflow changes in the gallbladder lasts longer than 4 weeks. From this investigation the conclusion can be drawn that vagotomy does not cause long lasting and radical bloodflow changes in the abdomen.
Asunto(s)
Sistema Digestivo/irrigación sanguínea , Nervio Vago/fisiología , Animales , Desoxiglucosa/farmacología , Perros , Duodeno/irrigación sanguínea , Ayuno , Vesícula Biliar/irrigación sanguínea , Fundus Gástrico/irrigación sanguínea , Intestino Grueso/irrigación sanguínea , Intestino Delgado/irrigación sanguínea , Páncreas/irrigación sanguínea , Antro Pilórico/irrigación sanguínea , Flujo Sanguíneo Regional , Estimulación Química , Estómago/irrigación sanguínea , Vagotomía , Nervio Vago/efectos de los fármacosRESUMEN
UNLABELLED: In unanesthetized dogs, the mechanical activity of the antrum and pylorus was studied by means of strain gauge force transducers during fasting condition, after feeding, and following application of metoclopramide (Paspertin), before and after SPV without pyloroplasty, and after SPV with pyloroplasty respectively. RESULTS: 1) The mechanical activity during fasting condition differs from that after feeding. 2) During fasting, the contractile force is decreased for about 15%-20% after SPV without pyloroplasty and for about 50% after SPV with pyloroplasty. The frequency remains unchanged. 3) After feeding, the contractile force is decreased by about 50%, the frequency shows an increase of 100%. The same results can be obtained after SPV with or without pyloroplasty. 4) After metoclopramide the contractile force is increased up to 30%, during fasting, after feeding, and also before and after SPV. The frequency, however, shows no significant change. 5) The postoperative findings remained unchanged throughout the entire observation period (up to the 20th postoperative month).
Asunto(s)
Vaciamiento Gástrico/efectos de los fármacos , Píloro/cirugía , Vagotomía , Animales , Perros , Metoclopramida/farmacologíaRESUMEN
In five anesthetized cats the excretion of Tc-99m-DAIDA into the gallbladder and the small bowel and the d.g. reflux were visualized by a gamma camera and analyzed by a digital computer. A d.g. reflux index was calculated following stimulation of the gallbladder by ceruletide and test meals, before and after a Heineke-Mikulicz pyloroplasty. It could be demonstrated that tracing of bile with TC-99m-DAIDA can be used as a noninvasive method for the evaluation of the d.g. reflux. Gastric intubation increases the d.g. reflux rate. Ceruletide is a much more effective choleretic agent than test meals. Despite a wide pyloroplasty neither an augmented d.g. reflux nor gastritis was seen, probably due to the preserved antral innervation.
Asunto(s)
Bilis/metabolismo , Vaciamiento Gástrico , Píloro/cirugía , Animales , GatosRESUMEN
Iron absorption was studied in 35 volunteers following oral application of Tardyferon during 21 days. In 25 patients a total gastrectomy and in 5 patients a subtotal gastrectomy have been performed, whereas 5 persons served as controls. The following parameters have been determined: Serum iron, iron binding capacity, hemoglobin, hematocrit, red blood cells and reticulocytes. The following results were obtained: Serum iron is markedly reduced in the patients with total gastrectomy during the first postoperative year, increases steadily and reaches normal values after the third postoperative year. Following oral application of Tardyferon an improved absorption is observed during the postoperative course. Because of the excellent absorption of Tardyferon it can be recommended for the oral application during the first two postoperative years.
Asunto(s)
Gastrectomía , Hierro/metabolismo , Adulto , Anciano , Preparaciones de Acción Retardada , Femenino , Humanos , Absorción Intestinal , Hierro/administración & dosificación , Hierro/sangre , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
Primary and secondary bone healing were studied for 30 and 60 days, respectively, by means of X rays, scintigraphy, determination of callus thickness, scintillation counter, and determination of bone mineral content. Primary bone healing was terminated after 30 days, secondary healing after 60 days. Scintillation counting proved to be a quantitative method, the other methods serving as controls. The different influences on bone healing can be quantitatively studied by means of this model.
Asunto(s)
Fracturas Óseas/fisiopatología , Cicatrización de Heridas , Animales , Callo Óseo/diagnóstico por imagen , Fracturas Óseas/diagnóstico por imagen , Masculino , Minerales/análisis , Radiografía , Cintigrafía , Ratas , Tibia/análisis , Tibia/diagnóstico por imagen , Fracturas de la Tibia/fisiopatología , Factores de TiempoRESUMEN
Gastric secretion was studied in 188 fetuses of 28 pregnant dogs near term. Baseline secretory values were determined and gastric secretion was stimulated in additional fetuses with histamine, insulin, or gastrin. A significant increase in volume, acidity and pepsin output was observed in fetuses stimulated during the last week of gestation. Following maternal stimulation the placental transfer of histamine, insulin, and gastrin are demonstrated.
Asunto(s)
Úlcera Péptica/etiología , Animales , Animales Recién Nacidos , Perros , Femenino , Jugo Gástrico/metabolismo , Mucosa Gástrica/citología , Gastrinas/farmacología , Edad Gestacional , Histamina/farmacología , Insulina/farmacología , Embarazo , Estimulación Química , Estómago/fisiologíaRESUMEN
In four gastric fistula dogs we studied the effect of cimetidine (5 mg/kg/h) and somatostatin (10 microgram/kg/h), alone or in combination, on gastric secretion stimulated by histamine (160 microgram/kg/h) or pentagastrin (6 microgram/kg/h). Acid and pepsin output after histamine stimulation was more reduced by cimetidine than after pentagastrin stimulation. Somatostatin showed an inhibitory effect only after pentagastrin stimulation. The most effective reduction, both on the degree of inhibition and on duration after cessation of the inhibitors, was seen after the combination of cimetidine/somatostatin. These results give some clinical aspects for the use of these two agents.
Asunto(s)
Cimetidina/farmacología , Jugo Gástrico/metabolismo , Guanidinas/farmacología , Somatostatina/farmacología , Animales , Depresión Química , Perros , Determinación de la Acidez Gástrica , Jugo Gástrico/efectos de los fármacos , Mucosa Gástrica/efectos de los fármacos , Mucosa Gástrica/metabolismo , Histamina/farmacología , Masculino , Pentagastrina/farmacología , Pepsina A/análisisRESUMEN
The effect of thyrocalcitonin on secondary bone healing was studied in 180 Sprague-Dawley-rats. The right tibia of all the rats was osteotomized. Half of the animals was treated with thyrocalcitonin. Until the 60th postoperative day, the increase in 99mTc-methylendiphosphonate activity was measured and significant differences in ratios were noted. Between the postoperative days 10 to 25, there was a significant difference in the impulse quotients between the thyrocalcitonin and untreated rats (P less than 0.05). These results indicate that thyrocalcitonin may aid in secondary bone healing.
Asunto(s)
Calcitonina/uso terapéutico , Fijación Interna de Fracturas , Fracturas de la Tibia/cirugía , Cicatrización de Heridas/efectos de los fármacos , Animales , Difosfonatos , Masculino , Cintigrafía , Ratas , Ratas Endogámicas , Tecnecio , Medronato de Tecnecio Tc 99m , Fracturas de la Tibia/diagnóstico por imagenRESUMEN
Studies on why there is a higher disposition of carcinoma developing in the residual portion of the stomach of patients having undergone resections have led to the assumption that bacterial colonization constitutes a co-carcinogenic factor. It has been the purpose of this investigation to compare the ensuing bacterial growth following resective and nonresective stomach surgery. 120 Sprague-Dawley rats were divided into six groups: 1) control group: laparotomy. (2)SPV: with assured preservation of the antrum innervation. 3) SPV + Pypl.: the pyloroplasty was performed according to the Heinecke-upsilon. Mikulicz method. 4) TV + Pypl.: abdominal severance of the trunci nervi vagi. 5) BII: antecolonic without enteroanastomosis. 6) TV + BII. Eight months postoperative a smear was obtained under general anaesthesia from the transition segment between the fundus and antrum or at the site of the anastomosis. Tests for aerobic and anaerobic bacteria as well as cultures for fungi were begun. The control and SPV + Pypl. groups did not differ significantly in total bacteria count and in the ratio of nitrobacter. In contrast, the SPV group without pyloroplasty displayed an approximately tenfold higher concentration of nitrobacters--an amount equivalent to the sum of nitrobacters in the two resection techniques. The TV + BII group had a threefold higher total bacteria count than the BII group. According to our studies, a reduced stomach acid production, the bile secretion reflux and more importantly, a retarded food passage promote intragastric bacterial growth thus expediting the formation of intragastric carcinogenic nitrosamines.