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1.

Disruption of IRE1α through its kinase domain attenuates multiple myeloma.

Harnoss, Jonathan M; Le Thomas, Adrien; Shemorry, Anna; Marsters, Scot A; Lawrence, David A; Lu, Min; Chen, Yung-Chia Ariel; Qing, Jing; Totpal, Klara; Kan, David; Segal, Ehud; Merchant, Mark; Reichelt, Mike; Ackerly Wallweber, Heidi; Wang, Weiru; Clark, Kevin; Kaufman, Susan; Beresini, Maureen H; Laing, Steven T; Sandoval, Wendy; Lorenzo, Maria; Wu, Jiansheng; Ly, Justin; De Bruyn, Tom; Heidersbach, Amy; Haley, Benjamin; Gogineni, Alvin; Weimer, Robby M; Lee, Dong; Braun, Marie-Gabrielle; Rudolph, Joachim; VanWyngarden, Michael J; Sherbenou, Daniel W; Gomez-Bougie, Patricia; Amiot, Martine; Acosta-Alvear, Diego; Walter, Peter; Ashkenazi, Avi.

Proc Natl Acad Sci U S A; 116(33): 16420-16429, 2019 08 13.

Artículo en Inglés | MEDLINE | ID: mdl-31371506

2.

Optimization of globomycin analogs as novel gram-negative antibiotics.

Garland, Keira; Pantua, Homer; Braun, Marie-Gabrielle; Burdick, Daniel J; Castanedo, Georgette M; Chen, Yi-Chen; Cheng, Yun-Xing; Cheong, Jonathan; Daniels, Blake; Deshmukh, Gauri; Fu, Yuhong; Gibbons, Paul; Gloor, Susan L; Hua, Rongbao; Labadie, Sharada; Liu, Xiongcai; Pastor, Richard; Stivala, Craig; Xu, Min; Xu, Yiming; Zheng, Hao; Kapadia, Sharookh B; Hanan, Emily J.

Bioorg Med Chem Lett; 30(20): 127419, 2020 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-32768648

3.

Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp(3))-H Bonds.

Castanedo, Georgette; Liu, Yanzhou; Crawford, James J; Braun, Marie-Gabrielle.

J Org Chem; 81(18): 8617-24, 2016 09 16.

Artículo en Inglés | MEDLINE | ID: mdl-27529722

4.

Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.

Dorel, Ruth; Sun, Dawei; Carruthers, Nicholas; Castanedo, Georgette M; Ung, Peter M-U; Factor, Daniel C; Li, Tianbo; Baumann, Hannah; Janota, Danielle; Pang, Jodie; Salphati, Laurent; Meklemburg, Robert; Korman, Allison J; Harper, Halie E; Stubblefield, Samantha; Payandeh, Jian; McHugh, Daniel; Lang, Bradley T; Tesar, Paul J; Dere, Edward; Masureel, Matthieu; Adams, Drew J; Volgraf, Matthew; Braun, Marie-Gabrielle.

J Med Chem; 67(6): 4819-4832, 2024 Mar 28.

Artículo en Inglés | MEDLINE | ID: mdl-38470227

5.

Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.

Braun, Marie-Gabrielle; Ashkenazi, Avi; Beveridge, Ramsay E; Castanedo, Georgette; Wallweber, Heidi Ackerly; Beresini, Maureen H; Clark, Kevin R; De Bruyn, Tom; Fu, Liqiang; Gibbons, Paul; Jiang, Fan; Kaufman, Susan; Kan, David; Kiefer, James R; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Segal, Ehud; Sims, Jessica; Wang, Weiru; Wei, Wentao; Zhao, Liang; Schwarz, Jacob B; Rudolph, Joachim.

J Med Chem; 2024 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-38748820

6.

Palladium-catalyzed allylic C-H fluorination.

Braun, Marie-Gabrielle; Doyle, Abigail G.

J Am Chem Soc; 135(35): 12990-3, 2013 Sep 04.

Artículo en Inglés | MEDLINE | ID: mdl-23947740

7.

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Hanan, Emily J; Braun, Marie-Gabrielle; Heald, Robert A; MacLeod, Calum; Chan, Connie; Clausen, Saundra; Edgar, Kyle A; Eigenbrot, Charles; Elliott, Richard; Endres, Nicholas; Friedman, Lori S; Gogol, Emily; Gu, Xiao-Hui; Thibodeau, Rebecca Hong; Jackson, Philip S; Kiefer, James R; Knight, Jamie D; Nannini, Michelle; Narukulla, Raman; Pace, Amanda; Pang, Jodie; Purkey, Hans E; Salphati, Laurent; Sampath, Deepak; Schmidt, Stephen; Sideris, Steve; Song, Kyung; Sujatha-Bhaskar, Swathi; Ultsch, Mark; Wallweber, Heidi; Xin, Jianfeng; Yeap, SiewKuen; Young, Amy; Zhong, Yu; Staben, Steven T.

J Med Chem; 65(24): 16589-16621, 2022 12 22.

Artículo en Inglés | MEDLINE | ID: mdl-36455032

8.

A highly stereoselective, modular route to (E)-vinylsulfones and to (Z)- and (E)-alkenes.

Braun, Marie-Gabrielle; Quiclet-Sire, Béatrice; Zard, Samir Z.

J Am Chem Soc; 133(40): 15954-7, 2011 Oct 12.

Artículo en Inglés | MEDLINE | ID: mdl-21923183

9.

Highly demanding cross-metathesis in the synthesis of the C16-C30 fragment of dolabelide C.

Braun, Marie-Gabrielle; Vincent, Aurélie; Boumediene, Mehdi; Prunet, Joëlle.

J Org Chem; 76(12): 4921-9, 2011 Jun 17.

Artículo en Inglés | MEDLINE | ID: mdl-21534597

10.

Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.

Pantua, Homer; Skippington, Elizabeth; Braun, Marie-Gabrielle; Noland, Cameron L; Diao, Jingyu; Peng, Yutian; Gloor, Susan L; Yan, Donghong; Kang, Jing; Katakam, Anand Kumar; Reeder, Janina; Castanedo, Georgette M; Garland, Keira; Komuves, Laszlo; Sagolla, Meredith; Austin, Cary D; Murray, Jeremy; Xu, Yiming; Modrusan, Zora; Xu, Min; Hanan, Emily J; Kapadia, Sharookh B.

mBio; 11(5)2020 09 08.

Artículo en Inglés | MEDLINE | ID: mdl-32900806

11.

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.

Ferri, Elena; Le Thomas, Adrien; Wallweber, Heidi Ackerly; Day, Eric S; Walters, Benjamin T; Kaufman, Susan E; Braun, Marie-Gabrielle; Clark, Kevin R; Beresini, Maureen H; Mortara, Kyle; Chen, Yung-Chia A; Canter, Breanna; Phung, Wilson; Liu, Peter S; Lammens, Alfred; Ashkenazi, Avi; Rudolph, Joachim; Wang, Weiru.

Nat Commun; 11(1): 6387, 2020 12 14.

Artículo en Inglés | MEDLINE | ID: mdl-33318494

12.

Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity.

Beveridge, Ramsay E; Wallweber, Heidi Ackerly; Ashkenazi, Avi; Beresini, Maureen; Clark, Kevin R; Gibbons, Paul; Ghiro, Elise; Kaufman, Susan; Larivée, Alexandre; Leblanc, Melissa; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Rudolph, Joachim; Schwarz, Jacob B; Srivastava, Sanjay; Wang, Weiru; Zhao, Liang; Braun, Marie-Gabrielle.

ACS Med Chem Lett; 11(12): 2389-2396, 2020 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-33335661

13.

Introduction of Trifluoroethylamine as Amide Isostere by C-H Functionalization of Heteroarenes.

Braun, Marie-Gabrielle; Castanedo, Georgette; Qin, Ling; Salvo, Patrick; Zard, Samir Z.

Org Lett; 19(15): 4090-4093, 2017 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-28726421

14.

Tri- and tetrasubstituted functionalized vinyl sulfides by radical allylation.

Debien, Laurent; Braun, Marie-Gabrielle; Quiclet-Sire, Béatrice; Zard, Samir Z.

Org Lett; 15(24): 6250-3, 2013 Dec 20.

Artículo en Inglés | MEDLINE | ID: mdl-24266882

15.

An approach to α-keto vinyl carbinols.

Braun, Marie-Gabrielle; Zard, Samir Z.

Org Lett; 13(4): 776-9, 2011 Feb 18.

Artículo en Inglés | MEDLINE | ID: mdl-21244049

16.

Transfer of chirality by the use of an all carbon tether.

Braun, Marie-Gabrielle; Heng, Rama; Zard, Samir Z.

Org Lett; 13(5): 1230-3, 2011 Mar 04.

Artículo en Inglés | MEDLINE | ID: mdl-21288011

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