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1.
Artículo en Inglés | MEDLINE | ID: mdl-37610644

RESUMEN

Family inpatient units in child and adolescent mental health (CAMH) services engage all admitted family members in the treatment of children's symptoms. Studies demonstrated improvements in child and family functioning following family inpatient treatment, but evidence regarding predictors of treatment outcome is lacking. We analyzed data of families (n = 66) who received a four-week inpatient treatment for families with severe parent-child interaction problems. Hierarchical linear regression analyses revealed that parents who recalled harsher parenting practices of their own fathers reported greater improvements in their children's externalizing and internalizing problems. Greater improvements in externalizing problems were further predicted by lower parental educational level, less adverse impacts of stressful life events, and less internalizing child problems prior to admission. We therefore conclude that family inpatient treatment was particularly effective for children in families with lower parental education and a history of harsh parenting.

2.
Eur Child Adolesc Psychiatry ; 31(4): 553-564, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33277675

RESUMEN

The aim of this study was to investigate which factors predict lifetime reports of delinquent behavior in young adults who had received adaptive multimodal treatment of attention-deficit/hyperactivity disorder (ADHD) starting at ages 6-10 years. Participants were reassessed 13-24 years (M = 17.6, SD = 1.8) after they had received individualized ADHD treatment in the Cologne Adaptive Multimodal Treatment Study (CAMT). Their behavior was classified as non-delinquent (n = 34) or delinquent (n = 25) based on self-reports regarding the number of police contacts, offenses, and convictions at follow-up. Childhood variables assessed at post-intervention (e.g., externalizing child behavior problems, intelligence, and parenting behavior) that were significantly associated with group membership were entered as possible predictors of delinquency in a Chi-squared automatic interaction detector (CHAID) analysis. Delinquent behavior during adolescence and adulthood was best predicted by (a) meeting the symptom count diagnostic criteria for conduct disorder (CD) according to parent ratings, in combination with a nonverbal intelligence of IQ ≤ 106 at post-intervention, and (b) delinquent behavior problems (teacher rating) at post-intervention. The predictor variables specified in the CHAID analysis classified 81% of the participants correctly. The results support the hypothesis that a childhood diagnosis of ADHD is only predictive of delinquent behavior if it is accompanied by early conduct behavior problems. Low nonverbal intelligence was found to be an additional risk factor. These findings underline the importance of providing behavioral interventions that focus on externalizing behavior problems to children with ADHD and comorbid conduct problems.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Trastornos de la Conducta Infantil , Trastorno de la Conducta , Problema de Conducta , Adolescente , Adulto , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Trastorno por Déficit de Atención con Hiperactividad/epidemiología , Trastorno por Déficit de Atención con Hiperactividad/terapia , Niño , Trastornos de la Conducta Infantil/diagnóstico , Terapia Combinada , Trastorno de la Conducta/diagnóstico , Trastorno de la Conducta/epidemiología , Trastorno de la Conducta/terapia , Humanos , Adulto Joven
3.
Z Kinder Jugendpsychiatr Psychother ; 46(4): 316-324, 2018 Jul.
Artículo en Alemán | MEDLINE | ID: mdl-29897013

RESUMEN

Family relations and behavioral-emotional problems in adolescents - an analysis with the adolescent version of the Family Relations Test for Children and Adolescents Abstract. OBJECTIVES: So far hardly any instruments are available for the German-speaking countries, covering family relations from the perspective of young people reliably. Moreover, the relationship between family relations from the perspective of young people and behavioral problems has been rarely investigated. METHOD: Based on the Family Relations Test, which has been developed originally for children, the Family Relations Test for Children and Adolescents was developed in order to assess the family relations from the perspective of adolescents (94 items, 44 % newly developed). A clinical sample (n = 152) and a field sample (n = 132) was tested with this instrument and additionally behavioural problems of the adolescents were rated by the parents and the adolescents. RESULTS: The two-factor solution of the principal component analysis resulted in a clear distinction between two factors describing positive and negative family relations. The internal consistencies (Cronbach's Alpha) of the scales describing positive and negative relations are between .91 and .93. On these total scores young people from the clinic sample describe overall stronger negative relations in their families compared to young people in the field sample. Within the clinic sample moderate correlations between the extent of mental problems of young people rated by themselves and their parents could be found. CONCLUSIONS: Positive and negative relationships of young people to the individual family members and to all members of the family as a whole can be assessed reliably and factorially valid. As expected, significant correlations between negative family relations and mental problems could be found. The adolescent version of the Family Relations Test for Children and Adolescents proves to be a useful tool, to assess family relationships from the perspective of young people and thus to identify possible factors maintaining mental disorders of young people.


Asunto(s)
Trastornos de la Conducta Infantil/psicología , Relaciones Familiares/psicología , Relaciones Padres-Hijo , Psicometría/métodos , Encuestas y Cuestionarios , Adolescente , Síntomas Afectivos/diagnóstico , Síntomas Afectivos/psicología , Trastornos de la Conducta Infantil/diagnóstico , Comparación Transcultural , Conflicto Familiar/psicología , Femenino , Alemania , Humanos , Masculino , Trastornos Mentales/diagnóstico , Trastornos Mentales/psicología , Responsabilidad Parental/psicología , Reproducibilidad de los Resultados , Factores de Riesgo , Estadística como Asunto
4.
BMC Psychiatry ; 15: 288, 2015 Nov 16.
Artículo en Inglés | MEDLINE | ID: mdl-26573683

RESUMEN

BACKGROUND: The importance of parental involvement in child treatment is well-established. Several child psychiatric clinics have, therefore, set up inpatient family units where children and parents are both actively involved in the treatment. Unfortunately, evidence supporting the benefits of these units is sparse. METHODS: We evaluated the effectiveness of inpatient treatment for families with severe parent-child interaction problems in a child psychiatric setting. Consecutive admissions to the parent-child ward (N = 66) were studied. A within-subjects design was used with four assessment points (baseline, admission, discharge, four-week follow-up). Outcome measures were 1) parent and teacher ratings of child behaviour, and 2) parent self-ratings of parenting practices, parental strains and parental mental health. Data were analyzed using multilevel modelling for longitudinal data (piecewise growth curve models). RESULTS: All parent-rated measures improved significantly during the four-week treatment period (d = 0.4 - 1.3). These improvements were significantly greater than those observed during the four-week pre-admission period. In addition, benefits were maintained during the four-week follow-up period. Only parents' self-efficacy in managing their child's behaviour showed continued improvement during follow-up. Teacher ratings of children's disruptive behaviour at school were stable during the pre-admission period and showed significant improvements at follow-up (d = 0.3 - 0.4). CONCLUSIONS: We conclude that parent-child inpatient treatment has positive effects on child and parent behaviour and mental health, and can therefore be recommended for children with behavioural and emotional disorders and severe parent-child interaction problems.


Asunto(s)
Trastornos de la Conducta Infantil/terapia , Hospitalización , Trastornos del Humor/terapia , Relaciones Padres-Hijo , Adolescente , Niño , Trastornos de la Conducta Infantil/psicología , Preescolar , Humanos , Pacientes Internos/psicología , Masculino , Trastornos del Humor/psicología , Análisis Multinivel , Padres/psicología , Alta del Paciente
5.
Child Psychiatry Hum Dev ; 46(1): 44-56, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24638884

RESUMEN

The Cologne Adaptive Multimodal Treatment (CAMT) study demonstrated that adaptive and individually tailored multimodal treatment for attention-deficit/hyperactivity disorder (ADHD) [consisting of behavior therapy (BT) and/or stimulant medication] is highly effective. This study reports findings of the 18 month follow-up assessment. Parents and teachers completed broad range behavior scales (Child Behavior Checklist/Teacher Report Form) and standardized ADHD and oppositional defiant disorder/conduct disorder symptom rating scales. Children that used medication to treat ADHD at follow-up (N = 32) and those that did not (N = 34) were analyzed separately. Parents did not report significant changes in child behavior from posttest to follow-up. Teacher ratings revealed some aggravation of ADHD symptoms in children that received medication, but this was not significant after Bonferroni correction. The initial advantage of combined treatment over BT was no longer evident. It can be concluded that treatment for ADHD that is tailored to the assessed needs of children results in large treatment effects that are maintained for at least 18 months.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/terapia , Terapia Conductista/métodos , Estimulantes del Sistema Nervioso Central/farmacología , Metilfenidato/farmacología , Estimulantes del Sistema Nervioso Central/administración & dosificación , Niño , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Masculino , Metilfenidato/administración & dosificación , Resultado del Tratamiento
6.
Z Kinder Jugendpsychiatr Psychother ; 43(4): 275-86; quiz 287-8, 2015 Jul.
Artículo en Alemán | MEDLINE | ID: mdl-26118815

RESUMEN

OBJECTIVES: The effects of guided self-help interventions for parents of children with ADHD have already been proven in randomized controlled trials. The objective of this study was to assess the effectiveness of this novel form of intervention under routine care conditions in a nationwide trial. METHOD: Registered pediatricians as well as child and youth psychiatrists enrolled 274 children between 6 and 12 years old (83.6% male) diagnosed with ADHD to a self-help program for parents of children with ADHD. The program lasted for 1 year and consisted of eight booklets with advice for parenting children with ADHD as well as complementary telephone consultations (14 calls, up to 20 minutes each). The course of the ADHD symptoms and the comorbid symptoms as well as the development of the child's individual problems were assessed in a pre-post design. RESULTS: 63% of the enrolled parents adhered to the program until the end. The families who cancelled the program did not differ concerning the severity of ADHD symptoms, but they did more often show an impaired familial and social background, and their children received pharmacological treatment more often. Three-fourths of the children who completed the program had received pharmacological treatment at the beginning of the program. The children had more severe ADHD symptoms than a clinical control group. During the intervention, ADHD symptoms as well as psychosocial functioning improved with large effect sizes of d>0.9. Additionally, comorbid oppositional and emotional symptoms decreased. CONCLUSIONS: These results indicate that guided self-help programs for families with children with ADHD are effective, also as an addition to pharmacological treatment.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/psicología , Trastorno por Déficit de Atención con Hiperactividad/rehabilitación , Biblioterapia/métodos , Biblioterapia/organización & administración , Educación no Profesional/métodos , Educación no Profesional/organización & administración , Derivación y Consulta/organización & administración , Grupos de Autoayuda/organización & administración , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Estimulantes del Sistema Nervioso Central/uso terapéutico , Niño , Terapia Combinada , Femenino , Estudios de Seguimiento , Alemania , Humanos , Masculino , Teléfono
7.
Z Kinder Jugendpsychiatr Psychother ; 40(1): 51-60, 2012 Jan.
Artículo en Alemán | MEDLINE | ID: mdl-22161942

RESUMEN

OBJECTIVE: The current analysis was conducted on 16- to 22-year-old persons who had received a multimodal treatment for ADHD during their childhood. The main objective was to analyse the relationships between current intellectual abilities and current ADHD symptoms, comorbid symptoms, and medication history. METHOD: In an 8.5-year follow-up study current intellectual ability was assessed with the German version of the KAIT (K-TIM). Behavioural problems were rated by parents and the former patients via standardized questionnaires and a semistructured interview. T-tests, Pearson correlations, and multiple regression analyses were then conducted. RESULTS: No significant correlations were found between former treatment with medication and current intellectual abilities. Moreover, no relationship was found between intellectual abilities and current ADHD symptoms as assessed by self- and parent-rating via questionnaires. However, adolescents with lower IQ did show higher scores of problematic performance behavior during the test. Also, a correlation was found between overall clinical judgement and externalizing problem behavior at home and in school. CONCLUSIONS: Only small correlations were found between the current residual symptoms and intelligence in adolescent and young adults who had received a diagnosis of ADHD in childhood.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/terapia , Terapia Conductista/métodos , Estimulantes del Sistema Nervioso Central/uso terapéutico , Trastornos de la Conducta Infantil/terapia , Pruebas de Inteligencia/estadística & datos numéricos , Metilfenidato/uso terapéutico , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Trastorno por Déficit de Atención con Hiperactividad/psicología , Estimulantes del Sistema Nervioso Central/efectos adversos , Niño , Trastornos de la Conducta Infantil/diagnóstico , Trastornos de la Conducta Infantil/psicología , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Inteligencia/efectos de los fármacos , Control Interno-Externo , Masculino , Metilfenidato/efectos adversos , Determinación de la Personalidad/estadística & datos numéricos , Solución de Problemas/efectos de los fármacos
8.
J Atten Disord ; 26(7): 1018-1032, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-34697953

RESUMEN

OBJECTIVE: This longitudinal study examined early predictors of educational attainment and occupational functioning in adults with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD). METHOD: Participants (n = 70) of the Cologne Adaptive Multimodal Treatment (CAMT) Study were diagnosed with ADHD and received adaptive multimodal ADHD treatment during childhood. They were then followed through adolescence into adulthood. RESULTS: Hierarchical regression analysis revealed that poor reading skill and externalizing behaviors in childhood were early predictors of educational and occupational difficulties in adulthood. The use of stimulant medication in childhood predicted lower high school achievement, probably because medication use was confounded by indication. The regression models improved when intelligence scores and/or externalizing behaviors, especially delinquency, assessed in adolescence were considered as additional predictors. CONCLUSION: Children with ADHD, who continue to show reading difficulties and externalizing behavior problems after initial treatment, are at risk for educational and occupational difficulties and may need additional support.


Asunto(s)
Éxito Académico , Trastorno por Déficit de Atención con Hiperactividad , Adolescente , Adulto , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Trastorno por Déficit de Atención con Hiperactividad/epidemiología , Trastorno por Déficit de Atención con Hiperactividad/terapia , Niño , Terapia Combinada , Escolaridad , Humanos , Estudios Longitudinales , Adulto Joven
9.
Eur Child Adolesc Psychiatry ; 20 Suppl 2: S277-88, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21901414

RESUMEN

Methylphenidate (MPH) is the most commonly prescribed stimulant for children with ADHD. Data on the effects of different MPH formulations in real-life settings are scarce, and the role of previous therapy on treatment outcome when switching medications has not been well studied. OBSEER was an observational study designed to evaluate the effectiveness and safety of Equasym XL(®) in routine care. This study assessed whether the improvements reported with Equasym XL(®) are influenced by the degree of symptom control achieved with the previous medication. Patients enrolled in OBSEER were stratified by prior treatment (none, MPH-immediate release [IR] once daily [o.d.] [MPH-IR o.d.], MPH-IR repeated [MPH-IR >o.d.] and MPH-MR [modified release] excluding Equasym XL(®)), and changes in ADHD and other externalising symptoms (CGI-S, FBB-ADHD and DAYAS) and quality of life (QoL, KINDL) were evaluated during treatment with Equasym XL(®). A total of 782 patients were analysed. Significant group-by-time interactions were found for all symptom variables analysed, indicating that effects varied by previous medication. For CGI-S and FBB-ADHD total scores, the greatest reductions in ADHD symptoms were observed in the treatment-naïve subgroup, followed (in order) by MPH-IR o.d., MPH-IR >o.d. and MPH-MR. A similar profile was seen for DAYAS ratings for all periods of the day except the evening, when there were no significant differences between subgroups. Similarly, the treatment-naïve and MPH-IR o.d. subgroups showed the greatest improvements in KINDL ratings. Although effects were greatest for treatment-naïve patients, improvements were also observed in the prior treatment subgroups for symptoms and QoL. This suggests that a change to Equasym XL(®) may be beneficial in patients with suboptimal effects on prior medication.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/administración & dosificación , Metilfenidato/administración & dosificación , Calidad de Vida/psicología , Índice de Severidad de la Enfermedad , Actividades Cotidianas/psicología , Administración Oral , Adolescente , Conducta del Adolescente/psicología , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Conducta Infantil/psicología , Preparaciones de Acción Retardada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Alemania , Humanos , Resultado del Tratamiento
10.
Eur Child Adolesc Psychiatry ; 20 Suppl 2: S257-65, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21901416

RESUMEN

Attention deficit hyperactivity disorder (ADHD) impacts significantly on the quality of life (QoL) of patients and their families. Choice of therapy is increasingly influenced by treatment satisfaction and patient preference, with once-daily modified-release methylphenidate (MPH-MR) formulations offering clear benefits compared with immediate-release (IR) dosage forms. The effects of MPH-MR on QoL in ADHD have not been widely investigated and need more clarity in practice. The open-label OBSEER study evaluated the effectiveness and tolerability of Equasym XL(®), a MPH-MR formulation, in routine practice. Children and adolescents (aged 6-17 years) with ADHD and attending school were included if Equasym XL(®) treatment was planned by the treating physician. Physicians, parents and patients completed questionnaires assessing QoL (KINDL; parent, child or adolescent versions), satisfaction with medication, adherence and treatment tolerability at baseline (Visit 1), 1-3 weeks (Visit 2) and 6-12 weeks (Visit 3) over a maximum 3-month observation period. Data from 822 consecutively referred patients were analysed. QoL and medication satisfaction increased from Visit 1 to Visit 3, with both patients and parents rating therapy with Equasym XL(®) as better than previous drug therapy. KINDL total score effect sizes were 0.67 (parents' ratings), 0.52 (children's ratings) and 0.51 (adolescents' ratings; all p < 0.001). All KINDL subscores also increased: both parents and patients had the greatest improvement for school. Adherence to Equasym XL(®) was frequently rated as superior to prior treatment, particularly compared with MPH-IR repeated dosing. Treatment was generally well tolerated; approximately 3% of the patients discontinued treatment due to adverse events. Equasym XL(®) improved QoL compared with prior therapy, and resulted in good medication satisfaction and adherence in drug-naïve and previously treated patients.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/administración & dosificación , Cumplimiento de la Medicación , Metilfenidato/administración & dosificación , Calidad de Vida/psicología , Índice de Severidad de la Enfermedad , Actividades Cotidianas/psicología , Administración Oral , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Preparaciones de Acción Retardada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Alemania , Humanos , Desempeño Psicomotor/efectos de los fármacos , Resultado del Tratamiento
11.
Eur Child Adolesc Psychiatry ; 20 Suppl 2: S297-307, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21901412

RESUMEN

Satisfaction with medication is important in the evaluation of overall treatment outcome. There is a lack of consistent and validated rating scales for satisfaction with medication in ADHD, therefore comparison across studies is difficult. Here, we analyse the psychometric properties of the satisfaction with medication scale (SAMS), a new item-based questionnaire that assesses satisfaction with ADHD medication. Furthermore, we evaluate the predictive effect of ADHD symptoms and quality of life (QoL) on satisfaction. Data on satisfaction with Equasym XL(®) (methylphenidate) were collected in the OBSEER study using the parent (SAMS-P, n = 589) and patient (SAMS-S, n = 552) versions of the SAMS questionnaire. Internal consistency, item-total and cross-informant correlations, and the stability of satisfaction ratings over time were assessed. Satisfaction with medication scores were then correlated with ratings of ADHD symptoms and QoL. Rates of overall satisfaction with Equasym XL(®) among parents and children were high (>70%), as was internal consistency for both SAMS-P and SAMS-S (Cronbach's alpha > 0.9). Similarly, item-total correlations were high (r = 0.71-0.90) for SAMS-P and medium-high (r = 0.57-0.77) for SAMS-S. Cross-informant correlations and the stability of satisfaction ratings were moderate (r = 0.54-0.59 and 0.48-0.60, respectively). ADHD symptom and QoL ratings were significantly negative and positive predictors of satisfaction, explaining 36-52% of satisfaction variance at the final visit. The results show that parent and patient satisfaction was high and could be assessed reliably with the new SAMS questionnaire. Parent and patient ratings were moderately correlated, and symptom severity, functional impairment and QoL were the most significant predictors of satisfaction.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/administración & dosificación , Metilfenidato/administración & dosificación , Relaciones Padres-Hijo , Satisfacción del Paciente/estadística & datos numéricos , Administración Oral , Adolescente , Conducta del Adolescente/psicología , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Conducta Infantil/psicología , Preparaciones de Acción Retardada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Alemania , Humanos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
12.
Eur Child Adolesc Psychiatry ; 20 Suppl 2: S289-96, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21901413

RESUMEN

DAYAS is a new two-part rating scale that assesses: (1) ADHD and ODD symptoms (externalising symptom ratings) and (2) symptomatology potentially related to ADHD medication (potentially medication-related symptoms) in real-world settings at different time periods throughout a normal school day. Data from a proof-of-concept study and two observational trials (Medikinet(®) retard [methylphenidate] and the Equasym XL(®) [methylphenidate] OBSEER study) evaluated: (1) validity of weekly externalising symptom ratings using DAYAS, in place of daily ratings; (2) reliability and internal consistency of DAYAS ratings for externalising symptoms and potentially medication-related symptoms; and (3) convergent and divergent validity of the externalising symptom ratings with existing validated scales. From the proof-of-concept study, daily scores by period of day and during the whole day correlated strongly with equivalent weekly scores (r = 0.83-0.92). Internal consistency of externalising symptom rating scales calculated from pooled data were acceptable or good by period of day (Cronbach's alpha = 0.68-0.90) and very high for whole day scores (Cronbach's alpha = 0.88-0.95). Internal consistency of the rating scale for potentially medication-related symptoms was also good for both teacher and parent ratings. From OBSEER data, correlations between FBB-ADHD total symptom scores and ratings on both parent and teacher versions of DAYAS were high (r = 0.73 and r = 0.84, respectively). Correlations between DAYAS and SDQ were highest for the SDQ subscales hyperactivity and conduct problems and substantially lower for pro-social behaviour, peers and emotional problems. The DAYAS rating scale had good internal consistency, and DAYAS scores correlated well with existing validated scales and the SDQ subscales hyperactivity and conduct problems. Weekly DAYAS scores (whole day and by period of day) could be considered a suitable replacement for daily assessment scores.


Asunto(s)
Actividades Cotidianas , Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/administración & dosificación , Docentes , Metilfenidato/administración & dosificación , Padres , Administración Oral , Adolescente , Adulto , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Preparaciones de Acción Retardada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Alemania , Humanos , Persona de Mediana Edad , Relaciones Padres-Hijo , Reproducibilidad de los Resultados , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
13.
Eur Child Adolesc Psychiatry ; 20 Suppl 2: S267-75, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21901415

RESUMEN

Although ADHD significantly affects the quality of life (QoL) of patients and their families, QoL in children with ADHD has rarely been investigated in association with psychopathological profile, and the relationship remains unclear. The open-label OBSEER study evaluated the effectiveness and tolerability of Equasym XL(®), a modified-release methylphenidate, in routine care of children and adolescents (aged 6-17 years) with ADHD. At baseline, questionnaires assessing psychopathological profile (Strengths and Difficulties Questionnaire, SDQ; parental ratings) and QoL (KINDL; parent, child or adolescent versions) were completed; QoL was reassessed at final visit. We analysed the relationship between psychopathology and parent/patient-rated QoL in ADHD at baseline. Data from 721 consecutively referred children and adolescents were analysed. QoL was similarly low from parent and self-ratings and independent of severity on the SDQ subscale hyperactivity/inattention. Self-ratings indicated that additional conduct disorder was associated with further reduction in QoL. Similarly, children with high scores from parent and adolescent ratings on the SDQ subscale conduct problems had reduced QoL on some KINDL subscales. Adolescents with ADHD not receiving medication at baseline reported lower QoL than those already on medication. Results show that children and adolescents with ADHD have low QoL, independent of core symptom severity. Additional conduct problems may further impact QoL negatively, while ADHD medication use may show a trend towards improved QoL. Not all psychopathological problems associated with ADHD affect QoL similarly. As parents appear to have a less critical view of QoL compared with children's self-ratings, both parent and child ratings should be included in clinical assessments.


Asunto(s)
Conducta del Adolescente/psicología , Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/administración & dosificación , Conducta Infantil/psicología , Metilfenidato/administración & dosificación , Padres/psicología , Calidad de Vida/psicología , Actividades Cotidianas/psicología , Administración Oral , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Preparaciones de Acción Retardada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Alemania , Humanos , Relaciones Padres-Hijo , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios , Resultado del Tratamiento
14.
Eur Child Adolesc Psychiatry ; 20 Suppl 2: S243-55, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21901417

RESUMEN

ADHD affects over 5% of children worldwide. It is typically treated with stimulant medications, and methylphenidate (MPH) is the most commonly prescribed. This study investigated the effectiveness, on symptoms and impairment, and safety of Equasym XL(®), a combination of 30% immediate-release and 70% modified-release MPH, in the treatment of ADHD in daily clinical practice. This open-label, observational, post-marketing surveillance study was conducted in 169 centres in Germany. Eligible patients, aged 6-17 years, were diagnosed with ADHD and about to begin treatment with Equasym XL(®). Effectiveness was assessed by physicians using the clinical global impression (CGI) severity and improvement scales; teachers and parents completed questionnaires evaluating ADHD symptoms and behavioural problems (DAYAS, FBB-ADHD and SDQ-P). Assessments were carried out at baseline, after 1-3 and 6-12 weeks of treatment. Of 852 enrolled patients, 822 were evaluable; 25.30% were treatment naïve, 69.84% had previously received different MPH formulations, and 4.87% had received other medications. ADHD symptoms improved from baseline to last visit for the majority of patients for all outcome measures. According to physician ratings of core ADHD symptoms, 75.73% of patients showed improvements on the CGI-Improvement scale, 17.77% had no change, and 6.50% worsened. In teacher and parent ratings, the effectiveness of Equasym XL(®) was rated better than prior therapy at all measured time points across the day, particularly late morning (teachers) and early afternoon (parents). Equasym XL(®) was generally well tolerated; only 3.16% of patients permanently discontinued treatment due to adverse events. Equasym XL(®) is effective and well tolerated in daily clinical practice.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/administración & dosificación , Cumplimiento de la Medicación , Metilfenidato/administración & dosificación , Seguridad , Índice de Severidad de la Enfermedad , Administración Oral , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Preparaciones de Acción Retardada , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Alemania , Humanos , Desempeño Psicomotor/efectos de los fármacos , Resultado del Tratamiento
15.
Res Dev Disabil ; 114: 103958, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33915381

RESUMEN

BACKGROUND: Children with intellectual disability (ID) are more likely to develop behavioural and emotional problems. However, specific interventions for the treatment of these problems in children with ID have rarely been evaluated. Parent management training (PMT) has been shown to be effective in reducing behavioural and emotional problems for other mental disorders. Therefore, we developed and evaluated a special PMT intervention for parents of children with ID. METHODS: The PMT was developed based on existing programs for children with other mental disorders. The effects of the PMT were analysed in a randomised controlled trial (intervention group: n = 21; waitlist control group: n = 21). The primary outcome was behavioural and emotional problems of children as rated by parents. Additionally, effects on parent-rated family burden and positive and negative parenting were assessed. OUTCOME: For the primary outcome, a statistically significant reduction of behavioural and emotional problems of the children emerged, with moderate effects for disruptive/ antisocial behaviour and anxiety. Family burden was reduced as a trend, with a small effect size. There was a significant increase in positive parenting and no effect on negative parenting.


Asunto(s)
Trastornos de la Conducta Infantil , Discapacidad Intelectual , Niño , Trastornos de la Conducta Infantil/terapia , Humanos , Responsabilidad Parental , Padres
16.
J Atten Disord ; 25(13): 1801-1817, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-32772881

RESUMEN

OBJECTIVE: ADHD treatment has positive effects on behavioral symptoms and psychosocial functioning, but studies that follow children treated for ADHD into adulthood are rare. METHOD: This follow-up study assessed symptom severity and functional outcomes of adults (n = 70) who had received individualized ADHD treatment in the Cologne Adaptive Multimodal Treatment (CAMT) Study at ages 6 to 10 years. RESULTS: Despite symptomatic improvement, participants reported poorer educational and occupational outcomes than expected (e.g., currently unemployed: 17%). They had also been in contact with the justice system more often than expected (e.g., lifetime convictions: 33%) and were impaired on health-related outcomes (e.g., substance use problems: 15%). Several social outcomes were favorable (e.g., long-term relationship/married: 63%). CONCLUSION: Compared to the general population or norm samples, CAMT participants had a higher relative risk (RR) of functional impairments, demonstrating the need for continued support for a substantial proportion of the young adults.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Trastornos Relacionados con Sustancias , Adulto , Trastorno por Déficit de Atención con Hiperactividad/terapia , Niño , Terapia Combinada , Estudios de Seguimiento , Humanos , Adulto Joven
17.
J Atten Disord ; 25(8): 1096-1106, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-31680604

RESUMEN

Objective: To evaluate the efficacy of an Omega-3/Omega-6 fatty acid supplement in preschool children at risk for ADHD. Method: Forty preschool children with elevated levels of ADHD symptoms were randomly assigned to either a verum or a placebo group. Children in the verum group received a 4-month treatment with Omega-3/Omega-6 fatty acids. Outcome measures comprised parent- and teacher-rated ADHD symptoms, which were the primary outcome variables, internalizing and externalizing problems, and intellectual abilities. Results: Intention-to-treat analyses of covariance, controlling for age and baseline data, revealed effects on parent- and teacher-rated ADHD symptoms (primary outcomes; parent ratings: F = 4.51, df = 1, p = .04, d = 0.63; teacher ratings: F = 4.67, df = 1, p = .04, d = 0.70), parent-rated internalizing symptoms (F = 8.47, df = 1, p < .01, d = 0.63), and parent- and teacher-rated externalizing symptoms (parent ratings: F = 4.58, df = 1, p = .04, d = 0.54; teacher ratings: F = 5.99, df = 1, p = .02, d = 0.79). Analyses involving only cases with available data yielded significant moderate effects on teacher-rated inattention symptoms (F = 4.60, df = 1, p = .04, d = 0.79) and parent-rated internalizing problems (F = 6.04, df = 1, p = .02, d = 0.57). Conclusion: The intention-to-treat analyses provide some evidence for positive effects of Omega-3/Omega-6 fatty acids. However, the results require replication in larger samples to allow for firm conclusions for practice.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Ácidos Grasos Omega-6 , Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Preescolar , Cognición , Suplementos Dietéticos , Humanos , Padres , Resultado del Tratamiento
18.
J Atten Disord ; 24(1): 145-162, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-27449186

RESUMEN

Objective: This study reassessed adolescents and young adults (15-22 years old) who received individually tailored multimodal treatment for ADHD (behavior therapy and/or stimulant medication) during childhood 6 to 12 years after treatment (M = 8.8 years, SD = 1.6). Method: All participants (N = 75) provided information about their social functioning. Most parents (83%) completed behavior rating scales. Results: Participants demonstrated significant improvement in behavior during the follow-up period with effect sizes on ADHD symptoms of d = 1.2 and 68% of the former patients in the normal range at follow-up. Participants reported elevated rates of grade retention (51%), school dropout (13%), special education service use (17%), school change (47%), and conviction (16%), but few were unemployed (4%). Conclusion: This study provides evidence that the effects of individually tailored multimodal treatment for ADHD in childhood are maintained into adolescence and young adulthood. No hints could be found that continued medication results in a more favorable long-term outcome.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Estimulantes del Sistema Nervioso Central , Metilfenidato , Adolescente , Adulto , Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Estimulantes del Sistema Nervioso Central/uso terapéutico , Niño , Terapia Combinada , Estudios de Seguimiento , Humanos , Metilfenidato/uso terapéutico , Adulto Joven
20.
Z Kinder Jugendpsychiatr Psychother ; 37(5): 431-40, 2009 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-19739061

RESUMEN

OBJECTIVES: This study analyzes the German version of the teacher rated Symptom Checklist for Attention Deficit Hyperactivity Disorders (FBB-HKS) which is part of the Diagnostic System of Mental Disorders in Children and Adolescents (DISYPS-KJ). Factorial validity as well as convergent, divergent und differential validity and reliability (internal consistency and retest reliability) of the scale are analyzed. METHODS: The questionnaire consists of 20 four point symptom items, assessing the 18 symptom-criteria according to ICD-10 und DSM-IV. Data were collected in a sample of pupils from a school for children with behavioral, emotional and learning problems (study 1: n = 50), as well as in a referred sample from a child and adolescent psychiatric outpatient clinic (study 2: n = 78), and a sample from a multi-center study on the effects of long-acting methylphenidate (study 3: n = 79). RESULTS: The exploratory and the confirmatory factor analyses confirm both a three factor structure with hyperactivity, impulsivity and inattention as separate factors and a two factor structure (with hyperactivity-impulsivity and inattention). Internal consistencies and retest reliabilities are in a good to very good range. Convergent, divergent and differential validity can be confirmed. Thus, the rating scale is suitable for the assessment of ADHD symptoms at school.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Determinación de la Personalidad/estadística & datos numéricos , Adolescente , Síntomas Afectivos/diagnóstico , Síntomas Afectivos/tratamiento farmacológico , Síntomas Afectivos/psicología , Trastorno por Déficit de Atención con Hiperactividad/tratamiento farmacológico , Trastorno por Déficit de Atención con Hiperactividad/psicología , Estimulantes del Sistema Nervioso Central/uso terapéutico , Niño , Trastornos de la Conducta Infantil/diagnóstico , Trastornos de la Conducta Infantil/tratamiento farmacológico , Trastornos de la Conducta Infantil/psicología , Preparaciones de Acción Retardada , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Educación Especial , Femenino , Alemania , Humanos , Clasificación Internacional de Enfermedades , Discapacidades para el Aprendizaje/diagnóstico , Discapacidades para el Aprendizaje/tratamiento farmacológico , Discapacidades para el Aprendizaje/psicología , Masculino , Metilfenidato/uso terapéutico , Estudios Multicéntricos como Asunto , Servicio Ambulatorio en Hospital , Psicometría/estadística & datos numéricos , Ensayos Clínicos Controlados Aleatorios como Asunto , Reproducibilidad de los Resultados , Resultado del Tratamiento
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