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1.
Br J Ophthalmol ; 108(2): 253-262, 2024 01 29.
Artículo en Inglés | MEDLINE | ID: mdl-36627173

RESUMEN

AIM: To explore associations between artificial intelligence (AI)-based fluid compartment quantifications and 12 months visual outcomes in OCT images from a real-world, multicentre, national cohort of naïve neovascular age-related macular degeneration (nAMD) treated eyes. METHODS: Demographics, visual acuity (VA), drug and number of injections data were collected using a validated web-based tool. Fluid compartment quantifications including intraretinal fluid (IRF), subretinal fluid (SRF) and pigment epithelial detachment (PED) in the fovea (1 mm), parafovea (3 mm) and perifovea (6 mm) were measured in nanoliters (nL) using a validated AI-tool. RESULTS: 452 naïve nAMD eyes presented a mean VA gain of +5.5 letters with a median of 7 injections over 12 months. Baseline foveal IRF associated poorer baseline (44.7 vs 63.4 letters) and final VA (52.1 vs 69.1), SRF better final VA (67.1 vs 59.0) and greater VA gains (+7.1 vs +1.9), and PED poorer baseline (48.8 vs 57.3) and final VA (55.1 vs 64.1). Predicted VA gains were greater for foveal SRF (+6.2 vs +0.6), parafoveal SRF (+6.9 vs +1.3), perifoveal SRF (+6.2 vs -0.1) and parafoveal IRF (+7.4 vs +3.6, all p<0.05). Fluid dynamics analysis revealed the greatest relative volume reduction for foveal SRF (-16.4 nL, -86.8%), followed by IRF (-17.2 nL, -84.7%) and PED (-19.1 nL, -28.6%). Subgroup analysis showed greater reductions in eyes with higher number of injections. CONCLUSION: This real-world study describes an AI-based analysis of fluid dynamics and defines baseline OCT-based patient profiles that associate 12-month visual outcomes in a large cohort of treated naïve nAMD eyes nationwide.


Asunto(s)
Mácula Lútea , Degeneración Macular , Desprendimiento de Retina , Degeneración Macular Húmeda , Humanos , Ranibizumab/uso terapéutico , Inhibidores de la Angiogénesis/uso terapéutico , Factor A de Crecimiento Endotelial Vascular , Inteligencia Artificial , Tomografía de Coherencia Óptica , Inyecciones Intravítreas , Desprendimiento de Retina/tratamiento farmacológico , Degeneración Macular/tratamiento farmacológico , Líquido Subretiniano , Degeneración Macular Húmeda/diagnóstico , Degeneración Macular Húmeda/tratamiento farmacológico
2.
Eye (Lond) ; 35(2): 425-432, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-32291404

RESUMEN

BACKGROUND/OBJECTIVES: To analyze the ophthalmic characteristics of congenital prepapillary vascular loop (PVL) and to propose a new morphologic classification dividing the loops into six types. SUBJECTS/METHODS: Collaborative multinational multicentre retrospective study of PVL cases. RESULTS: There was a total of 49 cases (61 eyes), 37 unilateral (75.5%) and 12 bilateral (24.5%), 32 arterial type (65.3%) and 18 venous type (36.7%) (one patient had either kind in each eye). The mean number of loops per eye was 2.7 (range, 1-7). The loops were asymptomatic in 42 cases (85.7%). Other findings included: the presence of cilioretinal artery (14 cases), retinal vascular tortuosity (26 cases), amaurosis fugax (1 case), branch retinal artery occlusion (1 case) and vitreous haemorrhage (3 cases). Six morphologic loop types could be discerned based on elevation (flat vs. elevated), shape (figure of 8 or corkscrew with hyaline sheath), number (multiple or single), location (central or peripheral), lumen size (arterial vs. arteriolar) and presence of vascular tortuosity or vitreous traction. CONCLUSIONS: PVL are usually asymptomatic and can be divided into six morphologic types with different pathogenesis during early embryogenesis.


Asunto(s)
Anomalías del Ojo , Malformaciones Vasculares , Humanos , Vasos Retinianos/anomalías , Estudios Retrospectivos , Malformaciones Vasculares/diagnóstico
3.
J Refract Surg ; 21(3): 298-300, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15977890

RESUMEN

PURPOSE: To report a case of bilateral giant retinal tear following posterior chamber phakic intraocular lens (PIOL) implantation. METHODS: A patient with an ocular history of retinal detachment associated with giant retinal tear 4 months after a bilateral PIOL implantation was referred with a macula on retinal detachment associated with giant retinal tear in the fellow eye. The patient underwent vitrectomy with silicone oil tamponade and an encircling buckle. Five months later, a lensectomy with phakic IOL and silicone oil removal were performed. RESULTS: The retina was reattached and has remained stable during 3-year follow-up. CONCLUSIONS: Although it is unclear whether retinal detachment associated with giant retinal tear following refractive procedures occurs within the normal incidence in myopic eyes, prophylactic measures are mandatory in high-risk fellow eyes.


Asunto(s)
Implantación de Lentes Intraoculares/efectos adversos , Cristalino/fisiología , Complicaciones Posoperatorias , Desprendimiento de Retina/etiología , Perforaciones de la Retina/etiología , Adulto , Humanos , Masculino , Desprendimiento de Retina/cirugía , Perforaciones de la Retina/cirugía , Curvatura de la Esclerótica , Aceites de Silicona/administración & dosificación , Vitrectomía
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