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1.

Multivariate phenotype analysis enables genome-wide inference of mammalian gene function.

Nicholson, George; Morgan, Hugh; Ganjgahi, Habib; Brown, Steve D M; Mallon, Ann-Marie; Holmes, Chris.

PLoS Biol; 20(8): e3001723, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35944064

2.

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.

Newton, Sherylanne; Kong, Fanbo; Carlton, Adam J; Aguilar, Carlos; Parker, Andrew; Codner, Gemma F; Teboul, Lydia; Wells, Sara; Brown, Steve D M; Marcotti, Walter; Bowl, Michael R.

PLoS Genet; 18(1): e1009937, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-35100259

3.

High-throughput mouse phenomics for characterizing mammalian gene function.

Brown, Steve D M; Holmes, Chris C; Mallon, Ann-Marie; Meehan, Terrence F; Smedley, Damian; Wells, Sara.

Nat Rev Genet; 19(6): 357-370, 2018 06.

Artículo en Inglés | MEDLINE | ID: mdl-29626206

4.

Helios is a key transcriptional regulator of outer hair cell maturation.

Chessum, Lauren; Matern, Maggie S; Kelly, Michael C; Johnson, Stuart L; Ogawa, Yoko; Milon, Beatrice; McMurray, Mark; Driver, Elizabeth C; Parker, Andrew; Song, Yang; Codner, Gemma; Esapa, Christopher T; Prescott, Jack; Trent, Graham; Wells, Sara; Dragich, Abigail K; Frolenkov, Gregory I; Kelley, Matthew W; Marcotti, Walter; Brown, Steve D M; Elkon, Ran; Bowl, Michael R; Hertzano, Ronna.

Nature; 563(7733): 696-700, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-30464345

5.

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.

Chee, Justine M; Lanoue, Louise; Clary, Dave; Higgins, Kendall; Bower, Lynette; Flenniken, Ann; Guo, Ruolin; Adams, David J; Bosch, Fatima; Braun, Robert E; Brown, Steve D M; Chin, H-J Genie; Dickinson, Mary E; Hsu, Chih-Wei; Dobbie, Michael; Gao, Xiang; Galande, Sanjeev; Grobler, Anne; Heaney, Jason D; Herault, Yann; de Angelis, Martin Hrabe; Mammano, Fabio; Nutter, Lauryl M J; Parkinson, Helen; Qin, Chuan; Shiroishi, Toshi; Sedlacek, Radislav; Seong, J-K; Xu, Ying; Brooks, Brian; McKerlie, Colin; Lloyd, K C Kent; Westerberg, Henrik; Moshiri, Ala.

BMC Biol; 21(1): 22, 2023 02 03.

Artículo en Inglés | MEDLINE | ID: mdl-36737727

6.

Advances in mouse genetics for the study of human disease.

Brown, Steve D M.

Hum Mol Genet; 30(R2): R274-R284, 2021 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-34089057

7.

High-throughput discovery of genetic determinants of circadian misalignment.

Zhang, Tao; Xie, Pancheng; Dong, Yingying; Liu, Zhiwei; Zhou, Fei; Pan, Dejing; Huang, Zhengyun; Zhai, Qiaocheng; Gu, Yue; Wu, Qingyu; Tanaka, Nobuhiko; Obata, Yuichi; Bradley, Allan; Lelliott, Christopher J; Nutter, Lauryl M J; McKerlie, Colin; Flenniken, Ann M; Champy, Marie-France; Sorg, Tania; Herault, Yann; Angelis, Martin Hrabe De; Durner, Valerie Gailus; Mallon, Ann-Marie; Brown, Steve D M; Meehan, Terry; Parkinson, Helen E; Smedley, Damian; Lloyd, K C Kent; Yan, Jun; Gao, Xiang; Seong, Je Kyung; Wang, Chi-Kuang Leo; Sedlacek, Radislav; Liu, Yi; Rozman, Jan; Yang, Ling; Xu, Ying.

PLoS Genet; 16(1): e1008577, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31929527

8.

INFRAFRONTIER quality principles in systemic phenotyping.

Ehlich, Hilke; Cater, Heather L; Flenniken, Ann M; Goncalves Da Cruz, Isabelle; Mura, Anne-Marie; Ntafis, Vasileios; Raess, Michael; Selloum, Mohammed; Stoeger, Claudia; Suchanova, Sarka; Vuolteenaho, Reetta; Brown, Steve D M; Hérault, Yann; Hinttala, Reetta; Hrabe de Angelis, Martin; Kollias, George; Kontoyiannis, Dimitris L; Malissen, Bernard; McKerlie, Colin; Sedlácek, Radislav; Wells, Sara E; Zarubica, Ana; Rozman, Jan; Sorg, Tania.

Mamm Genome; 33(1): 120-122, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34328547

9.

Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea.

Jeng, Jing-Yi; Carlton, Adam J; Johnson, Stuart L; Brown, Steve D M; Holley, Matthew C; Bowl, Michael R; Marcotti, Walter.

J Physiol; 599(1): 269-287, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-33179774

10.

Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.

Carlton, Adam J; Halford, Julia; Underhill, Anna; Jeng, Jing-Yi; Avenarius, Matthew R; Gilbert, Merle L; Ceriani, Federico; Ebisine, Kimimuepigha; Brown, Steve D M; Bowl, Michael R; Barr-Gillespie, Peter G; Marcotti, Walter.

J Physiol; 599(4): 1173-1198, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33151556

11.

Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea.

Jeng, Jing-Yi; Ceriani, Federico; Olt, Jennifer; Brown, Steve D M; Holley, Matthew C; Bowl, Michael R; Johnson, Stuart L; Marcotti, Walter.

J Physiol; 598(19): 4339-4355, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32710572

12.

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells.

Jeng, Jing-Yi; Johnson, Stuart L; Carlton, Adam J; De Tomasi, Lara; Goodyear, Richard J; De Faveri, Francesca; Furness, David N; Wells, Sara; Brown, Steve D M; Holley, Matthew C; Richardson, Guy P; Mustapha, Mirna; Bowl, Michael R; Marcotti, Walter.

J Physiol; 598(18): 3891-3910, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32608086

13.

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease.

Sethi, Siddharth; Vorontsov, Ilya E; Kulakovskiy, Ivan V; Greenaway, Simon; Williams, John; Makeev, Vsevolod J; Brown, Steve D M; Simon, Michelle M; Mallon, Ann-Marie.

BMC Genomics; 21(1): 754, 2020 Nov 02.

Artículo en Inglés | MEDLINE | ID: mdl-33138777

14.

Genetic landscape of auditory dysfunction.

Bowl, Michael R; Brown, Steve D M.

Hum Mol Genet; 27(R2): R130-R135, 2018 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-29726933

15.

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.

Corrochano, Silvia; Blanco, Gonzalo; Williams, Debbie; Wettstein, Jessica; Simon, Michelle; Kumar, Saumya; Moir, Lee; Agnew, Thomas; Stewart, Michelle; Landman, Allison; Kotiadis, Vassilios N; Duchen, Michael R; Wackerhage, Henning; Rubinsztein, David C; Brown, Steve D M; Acevedo-Arozena, Abraham.

Hum Mol Genet; 27(10): 1723-1731, 2018 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-29509900

16.

Cellular content plays a crucial role in Non-typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear.

Vikhe, Pratik P; Purnell, Tom; Brown, Steve D M; Hood, Derek W.

Cell Microbiol; 21(1): e12960, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30265765

17.

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

Crompton, Michael; Purnell, Tom; Tyrer, Hayley E; Parker, Andrew; Ball, Greg; Hardisty-Hughes, Rachel E; Gale, Richard; Williams, Debbie; Dean, Charlotte H; Simon, Michelle M; Mallon, Ann-Marie; Wells, Sara; Bhutta, Mahmood F; Burton, Martin J; Tateossian, Hilda; Brown, Steve D M.

PLoS Genet; 13(8): e1006969, 2017 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-28806779

18.

Cellular Immune Response against Nontypeable Haemophilus influenzae Infecting the Preinflamed Middle Ear of the Junbo Mouse.

Vikhe, Pratik P; Purnell, Tom; Brown, Steve D M; Hood, Derek W.

Infect Immun; 87(12)2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31548315

19.

The dark genome and pleiotropy: challenges for precision medicine.

Brown, Steve D M; Lad, Heena V.

Mamm Genome; 30(7-8): 212-216, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31444567

20.

Applying the ARRIVE Guidelines to an In Vivo Database.

Karp, Natasha A; Meehan, Terry F; Morgan, Hugh; Mason, Jeremy C; Blake, Andrew; Kurbatova, Natalja; Smedley, Damian; Jacobsen, Julius; Mott, Richard F; Iyer, Vivek; Matthews, Peter; Melvin, David G; Wells, Sara; Flenniken, Ann M; Masuya, Hiroshi; Wakana, Shigeharu; White, Jacqueline K; Lloyd, K C Kent; Reynolds, Corey L; Paylor, Richard; West, David B; Svenson, Karen L; Chesler, Elissa J; de Angelis, Martin Hrabe; Tocchini-Valentini, Glauco P; Sorg, Tania; Herault, Yann; Parkinson, Helen; Mallon, Ann-Marie; Brown, Steve D M.

PLoS Biol; 13(5): e1002151, 2015 May.

Artículo en Inglés | MEDLINE | ID: mdl-25992600

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