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1.

Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery.

Bogaert, Bram; Debisschop, Aliona; Ehouarne, Thomas; Van Eeckhoutte, Hannelore P; De Volder, Joyceline; Jacobs, An; Pottie, Eline; De Rycke, Riet; Crabbé, Aurélie; Mestdagh, Pieter; Lentacker, Ine; Brusselle, Guy G; Stove, Christophe; Verstraelen, Sandra; Maes, Tania; Bracke, Ken R; De Smedt, Stefaan C; Raemdonck, Koen.

Nano Lett; 24(10): 2961-2971, 2024 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-38477058

2.

Genome-wide association study of preserved ratio impaired spirometry (PRISm).

Higbee, Daniel H; Lirio, Alvin; Hamilton, Fergus; Granell, Raquel; Wyss, Annah B; London, Stephanie J; Bartz, Traci M; Gharib, Sina A; Cho, Michael H; Wan, Emily; Silverman, Edwin; Crapo, James D; Lominchar, Jesus V T; Hansen, Torben; Grarup, Niels; Dantoft, Thomas; Kårhus, Line; Linneberg, Allan; O'Connor, George T; Dupuis, Josée; Xu, Hanfie; De Vries, Maaike M; Hu, Xiaowei; Rich, Stephen S; Barr, R Graham; Manichaikul, Ani; Wijnant, Sara R A; Brusselle, Guy G; Lahousse, Lies; Li, Xuan; Hernández Cordero, Ana I; Obeidat, Ma'en; Sin, Don D; Harris, Sarah E; Redmond, Paul; Taylor, Adele M; Cox, Simon R; Williams, Alexander T; Shrine, Nick; John, Catherine; Guyatt, Anna L; Hall, Ian P; Davey Smith, George; Tobin, Martin D; Dodd, James W.

Eur Respir J; 63(1)2024 01.

Artículo en Inglés | MEDLINE | ID: mdl-38097206

3.

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

Lu, Tianqi; Lahousse, Lies; Wijnant, Sara; Chen, Jinluan; Brusselle, Guy G; van Hoek, Mandy; Zillikens, M Carola.

Respir Res; 25(1): 85, 2024 Feb 09.

Artículo en Inglés | MEDLINE | ID: mdl-38336742

4.

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.

Van Eeckhoutte, Hannelore P; Donovan, Chantal; Kim, Richard Y; Conlon, Thomas M; Ansari, Meshal; Khan, Haroon; Jayaraman, Ranjith; Hansbro, Nicole G; Dondelinger, Yves; Delanghe, Tom; Beal, Allison M; Geddes, Brad; Bertin, John; Vanden Berghe, Tom; De Volder, Joyceline; Maes, Tania; Vandenabeele, Peter; Vanaudenaerde, Bart M; Deforce, Dieter; Skevin, Sonja; Van Nieuwerburgh, Filip; Verhamme, Fien M; Joos, Guy F; Idrees, Sobia; Schiller, Herbert B; Yildirim, Ali Önder; Faiz, Alen; Bertrand, Mathieu J M; Brusselle, Guy G; Hansbro, Philip M; Bracke, Ken R.

Eur Respir J; 61(4)2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36549711

5.

Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly.

Mekic, Selma; Pardo, Luba M; Gunn, David A; Jacobs, Leonie C; Hamer, Merel A; Ikram, M Arfan; Vinke, Eline J; Vernooij, Meike W; Haarman, Annet E G; Thee, Eric F; Vergroesen, Joelle E; Klaver, Caroline C W; Croll, Pauline H; Goedegebure, Andre; Trajanoska, Katerina; Rivadeneira, Fernando; van Meurs, Joyce B J; Arshi, Banafsheh; Kavousi, Maryam; de Roos, Emmely W; Brusselle, Guy G O; Kayser, Manfred; Nijsten, Tamar.

Br J Dermatol; 188(3): 390-395, 2023 02 22.

Artículo en Inglés | MEDLINE | ID: mdl-36763776

6.

Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes.

Reddel, Helen K; Bacharier, Leonard B; Bateman, Eric D; Brightling, Christopher E; Brusselle, Guy G; Buhl, Roland; Cruz, Alvaro A; Duijts, Liesbeth; Drazen, Jeffrey M; FitzGerald, J Mark; Fleming, Louise J; Inoue, Hiromasa; Ko, Fanny W; Krishnan, Jerry A; Levy, Mark L; Lin, Jiangtao; Mortimer, Kevin; Pitrez, Paulo M; Sheikh, Aziz; Yorgancioglu, Arzu A; Boulet, Louis-Philippe.

Am J Respir Crit Care Med; 205(1): 17-35, 2022 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-34658302

7.

Sex-specific patterns and lifetime risk of multimorbidity in the general population: a 23-year prospective cohort study.

Velek, Premysl; Luik, Annemarie I; Brusselle, Guy G O; Stricker, Bruno Ch; Bindels, Patrick J E; Kavousi, Maryam; Kieboom, Brenda C T; Voortman, Trudy; Ruiter, Rikje; Ikram, M Arfan; Ikram, M Kamran; de Schepper, Evelien I T; Licher, Silvan.

BMC Med; 20(1): 304, 2022 09 08.

Artículo en Inglés | MEDLINE | ID: mdl-36071423

8.

Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma.

Edris, Ahmed; de Roos, Emmely W; McGeachie, Michael J; Verhamme, Katia M C; Brusselle, Guy G; Tantisira, Kelan G; Iribarren, Carlos; Lu, Meng; Wu, Ann Chen; Stricker, Bruno H; Lahousse, Lies.

Clin Exp Allergy; 52(1): 33-45, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-33428814

9.

MicroRNA miR-22 drives T(H)17 responses in emphysema.

Brusselle, Guy G; Bracke, Ken R.

Nat Immunol; 16(11): 1109-10, 2015 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-26482970

10.

IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients.

Jacobs, Merel; Verschraegen, Sven; Salhi, Bihiyga; Anckaert, Jasper; Mestdagh, Pieter; Brusselle, Guy G; Bracke, Ken R.

Respir Res; 23(1): 287, 2022 Oct 17.

Artículo en Inglés | MEDLINE | ID: mdl-36253785

11.

Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes.

Reddel, Helen K; Bacharier, Leonard B; Bateman, Eric D; Brightling, Christopher E; Brusselle, Guy G; Buhl, Roland; Cruz, Alvaro A; Duijts, Liesbeth; Drazen, Jeffrey M; FitzGerald, J Mark; Fleming, Louise J; Inoue, Hiromasa; Ko, Fanny W; Krishnan, Jerry A; Levy, Mark L; Lin, Jiangtao; Mortimer, Kevin; Pitrez, Paulo M; Sheikh, Aziz; Yorgancioglu, Arzu A; Boulet, Louis-Philippe.

Respirology; 27(1): 14-35, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-34668278

12.

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease.

Lu, Zhe; Van Eeckhoutte, Hannelore P; Liu, Gang; Nair, Prema M; Jones, Bernadette; Gillis, Caitlin M; Nalkurthi, B Christina; Verhamme, Fien; Buyle-Huybrecht, Tamariche; Vandenabeele, Peter; Vanden Berghe, Tom; Brusselle, Guy G; Horvat, Jay C; Murphy, James M; Wark, Peter A; Bracke, Ken R; Fricker, Michael; Hansbro, Philip M.

Am J Respir Crit Care Med; 204(6): 667-681, 2021 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-34133911

13.

MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation.

Roffel, Mirjam P; Maes, Tania; Brandsma, Corry-Anke; van den Berge, Maarten; Vanaudenaerde, Bart M; Joos, Guy F; Brusselle, Guy G; Heijink, Irene H; Bracke, Ken R.

Am J Physiol Lung Cell Mol Physiol; 321(6): L1091-L1104, 2021 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-34668437

14.

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression.

van der Plaat, Diana A; Vonk, Judith M; Terzikhan, Natalie; de Jong, Kim; de Vries, Maaike; La Bastide-van Gemert, Sacha; van Diemen, Cleo C; Lahousse, Lies; Brusselle, Guy G; Nedeljkovic, Ivana; Amin, Najaf; Kromhout, Hans; Vermeulen, Roel C H; Postma, Dirkje S; van Duijn, Cornelia M; Boezen, H Marike.

Hum Mol Genet; 28(15): 2477-2485, 2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31152171

15.

Treatment options in type-2 low asthma.

Hinks, Timothy S C; Levine, Stewart J; Brusselle, Guy G.

Eur Respir J; 57(1)2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-32586877

16.

The interrelatedness of chronic cough and chronic pain.

Arinze, Johnmary T; Verhamme, Katia M C; Luik, Annemarie I; Stricker, Bruno; van Meurs, Joyce B J; Brusselle, Guy G.

Eur Respir J; 57(5)2021 05.

Artículo en Inglés | MEDLINE | ID: mdl-33122337

17.

COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.

Nedeljkovic, Ivana; Lahousse, Lies; Carnero-Montoro, Elena; Faiz, Alen; Vonk, Judith M; de Jong, Kim; van der Plaat, Diana A; van Diemen, Cleo C; van den Berge, Maarten; Obeidat, Ma'en; Bossé, Yohan; Nickle, David C; Consortium, B I O S; Uitterlinden, Andre G; van Meurs, Joyce B J; Stricker, Bruno H C; Brusselle, Guy G; Postma, Dirkje S; Boezen, H Marike; van Duijn, Cornelia M; Amin, Najaf.

Hum Mol Genet; 27(2): 396-405, 2018 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-29092026

18.

Biologic Therapies for Severe Asthma.

Brusselle, Guy G; Koppelman, Gerard H.

N Engl J Med; 386(2): 157-171, 2022 01 13.

Artículo en Inglés | MEDLINE | ID: mdl-35020986

19.

Trajectory and mortality of preserved ratio impaired spirometry: the Rotterdam Study.

Wijnant, Sara Renata Alex; De Roos, Emmely; Kavousi, Maryam; Stricker, Bruno Hugo; Terzikhan, Natalie; Lahousse, Lies; Brusselle, Guy G.

Eur Respir J; 55(1)2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31601717

20.

Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155.

Blomme, Evy E; Provoost, Sharen; Bazzan, Erica; Van Eeckhoutte, Hannelore P; Roffel, Mirjam P; Pollaris, Lore; Bontinck, Annelies; Bonato, Matteo; Vandenbroucke, Louise; Verhamme, Fien; Joos, Guy F; Cosio, Manuel G; Vanoirbeek, Jeroen A J; Brusselle, Guy G; Saetta, Marina; Maes, Tania.

Eur Respir J; 56(3)2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32499335

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Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery.

Genome-wide association study of preserved ratio impaired spirometry (PRISm).

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study.

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.

Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly.

Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes.

Sex-specific patterns and lifetime risk of multimorbidity in the general population: a 23-year prospective cohort study.

Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma.

MicroRNA miR-22 drives T(H)17 responses in emphysema.

IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients.

Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes.

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease.

MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation.

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression.

Treatment options in type-2 low asthma.

The interrelatedness of chronic cough and chronic pain.

COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.

Biologic Therapies for Severe Asthma.

Trajectory and mortality of preserved ratio impaired spirometry: the Rotterdam Study.

Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155.