Detalles de la búsqueda
1.
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.
Pulm Pharmacol Ther;
52: 32-40, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30201409
2.
Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts.
Acta Derm Venereol;
97(1): 10-16, 2017 01 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27175945
3.
Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.
Am J Pathol;
183(2): 470-9, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23759512
4.
Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists.
Bioorg Med Chem Lett;
24(18): 4450-4454, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25155385
5.
Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
Dermatol Ther (Heidelb);
14(2): 489-504, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38372938
6.
BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis.
Mol Pharmacol;
83(1): 283-93, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23115324
7.
Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.
Blood;
118(17): 4750-8, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21900197
8.
Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
Blood;
117(1): 333-41, 2011 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-20724539
9.
Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells.
Microvasc Res;
85: 59-67, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23084965
10.
Epithelial-mesenchymal crosstalk alteration in kidney fibrosis.
J Pathol;
228(2): 131-47, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22570261
11.
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-ß in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.
Am J Physiol Lung Cell Mol Physiol;
302(6): L604-15, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22227206
12.
From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD.
Nephrol Dial Transplant;
27 Suppl 3: iii43-50, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22785113
13.
Study to Explore the Association of the Renin-Angiotensin System and Right Ventricular Function in Mechanically Ventilated Patients.
J Clin Med;
11(15)2022 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955981
14.
An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension.
Pulm Circ;
12(1): e12024, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-35506108
15.
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.
Circulation;
122(9): 920-7, 2010 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-20713898
16.
Effects of Recombinant Human Angiotensin-Converting Enzyme 2 on Response to Acute Hypoxia and Exercise: A Randomised, Placebo-Controlled Study.
Pulm Ther;
7(2): 487-501, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34189703
17.
Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.
Am J Pathol;
174(2): 380-9, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19116361
18.
Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
J Med Chem;
59(12): 5604-21, 2016 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-26745766
19.
Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway.
Biochem J;
381(Pt 1): 43-9, 2004 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15068397
20.
Development of lysophosphatidic acid pathway modulators as therapies for fibrosis.
Future Med Chem;
5(16): 1935-52, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24175745