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1.

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.

Baltgalvis, Kristen A; Lamb, Kelsey N; Symons, Kent T; Wu, Chu-Chiao; Hoffman, Melissa A; Snead, Aaron N; Song, Xiaodan; Glaza, Thomas; Kikuchi, Shota; Green, Jason C; Rogness, Donald C; Lam, Betty; Rodriguez-Aguirre, Maria E; Woody, David R; Eissler, Christie L; Rodiles, Socorro; Negron, Seth M; Bernard, Steffen M; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N; Pastuszka, Martha K; Sigler, John J; Pettazzoni, Piergiorgio; Rudolph, Markus G; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E; Abraham, Robert T; Weinstein, David S; Simon, Gabriel M; Patricelli, Matthew P; Kinsella, Todd M.

Nature; 629(8011): 435-442, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38658751

2.

Identification of the Clinical Development Candidate MRTX849, a Covalent KRAS^G12C Inhibitor for the Treatment of Cancer.

Fell, Jay B; Fischer, John P; Baer, Brian R; Blake, James F; Bouhana, Karyn; Briere, David M; Brown, Karin D; Burgess, Laurence E; Burns, Aaron C; Burkard, Michael R; Chiang, Harrah; Chicarelli, Mark J; Cook, Adam W; Gaudino, John J; Hallin, Jill; Hanson, Lauren; Hartley, Dylan P; Hicken, Erik J; Hingorani, Gary P; Hinklin, Ronald J; Mejia, Macedonio J; Olson, Peter; Otten, Jennifer N; Rhodes, Susan P; Rodriguez, Martha E; Savechenkov, Pavel; Smith, Darin J; Sudhakar, Niranjan; Sullivan, Francis X; Tang, Tony P; Vigers, Guy P; Wollenberg, Lance; Christensen, James G; Marx, Matthew A.

J Med Chem; 63(13): 6679-6693, 2020 07 09.

Artículo en Inglés | MEDLINE | ID: mdl-32250617

3.

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

Fell, Jay B; Fischer, John P; Baer, Brian R; Ballard, Joshua; Blake, James F; Bouhana, Karyn; Brandhuber, Barbara J; Briere, David M; Burgess, Laurence E; Burkard, Michael R; Chiang, Harrah; Chicarelli, Mark J; Davidson, Kevin; Gaudino, John J; Hallin, Jill; Hanson, Lauren; Hee, Kenneth; Hicken, Erik J; Hinklin, Ronald J; Marx, Matthew A; Mejia, Macedonio J; Olson, Peter; Savechenkov, Pavel; Sudhakar, Niranjan; Tang, Tony P; Vigers, Guy P; Zecca, Henry; Christensen, James G.

ACS Med Chem Lett; 9(12): 1230-1234, 2018 Dec 13.

Artículo en Inglés | MEDLINE | ID: mdl-30613331

4.

Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity.

D'Amico, Derin C; Aya, Toshi; Human, Jason; Fotsch, Christopher; Chen, Jian Jeffrey; Biswas, Kaustav; Riahi, Bobby; Norman, Mark H; Willoughby, Christopher A; Hungate, Randall; Reider, Paul J; Biddlecome, Gloria; Lester-Zeiner, Dianna; Staden, Carlo Van; Johnson, Eileen; Kamassah, Augustus; Arik, Leyla; Wang, Judy; Viswanadhan, Vellarkad N; Groneberg, Robert D; Zhan, James; Suzuki, Hideo; Toro, Andras; Mareska, David A; Clarke, David E; Harvey, Darren M; Burgess, Laurence E; Laird, Ellen R; Askew, Benny; Ng, Gordon.

J Med Chem; 50(4): 607-10, 2007 Feb 22.

Artículo en Inglés | MEDLINE | ID: mdl-17243660

5.

Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.

Biswas, Kaustav; Li, Aiwen; Chen, Jian Jeffrey; D'Amico, Derin C; Fotsch, Christopher; Han, Nianhe; Human, Jason; Liu, Qingyian; Norman, Mark H; Riahi, Bobby; Yuan, Chester; Suzuki, Hideo; Mareska, David A; Zhan, James; Clarke, David E; Toro, Andras; Groneberg, Robert D; Burgess, Laurence E; Lester-Zeiner, Dianna; Biddlecome, Gloria; Manning, Barton H; Arik, Leyla; Dong, Hong; Huang, Ming; Kamassah, Augustus; Loeloff, Richard; Sun, Hong; Hsieh, Feng-Yin; Kumar, Gondi; Ng, Gordon Y; Hungate, Randall W; Askew, Benny C; Johnson, Eileen.

J Med Chem; 50(9): 2200-12, 2007 May 03.

Artículo en Inglés | MEDLINE | ID: mdl-17408249

6.

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia.

Bachegowda, Lohith; Morrone, Kerry; Winski, Shannon L; Mantzaris, Ioannis; Bartenstein, Matthias; Ramachandra, Nandini; Giricz, Orsi; Sukrithan, Vineeth; Nwankwo, George; Shahnaz, Samira; Bhagat, Tushar; Bhattacharyya, Sanchari; Assal, Amer; Shastri, Aditi; Gordon-Mitchell, Shanisha; Pellagatti, Andrea; Boultwood, Jacqueline; Schinke, Carolina; Yu, Yiting; Guha, Chandan; Rizzi, James; Garrus, Jennifer; Brown, Suzy; Wollenberg, Lance; Hogeland, Grant; Wright, Dale; Munson, Mark; Rodriguez, Mareli; Gross, Stefan; Chantry, David; Zou, Yiyu; Platanias, Leonidas; Burgess, Laurence E; Pradhan, Kith; Steidl, Ulrich; Verma, Amit.

Cancer Res; 76(16): 4841-4849, 2016 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-27287719

7.

Inflammation Research Association: 12th international conference.

Chantry, David; Burgess, Laurence E.

Expert Opin Emerg Drugs; 10(1): 219-24, 2005 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-15757413

8.

Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-alpha, IL-6 and IL-1 beta: possible relevance to multiple sclerosis.

Malamud, Vivian; Vaaknin, Ady; Abramsky, Oded; Mor, Michal; Burgess, Laurence E; Ben-Yehudah, Ahmi; Lorberboum-Galski, Haya.

J Neuroimmunol; 138(1-2): 115-22, 2003 May.

Artículo en Inglés | MEDLINE | ID: mdl-12742661

9.

Chemokines in allergy.

Chantry, David; Burgess, Laurence E.

Curr Drug Targets Inflamm Allergy; 1(1): 109-16, 2002 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-14561210

10.

Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.

Hicken, Erik J; Marmsater, Fred P; Munson, Mark C; Schlachter, Stephen T; Robinson, John E; Allen, Shelley; Burgess, Laurence E; DeLisle, Robert Kirk; Rizzi, James P; Topalov, George T; Zhao, Qian; Hicks, Julie M; Kallan, Nicholas C; Tarlton, Eugene; Allen, Andrew; Callejo, Michele; Cox, April; Rana, Sumeet; Klopfenstein, Nathalie; Woessner, Richard; Lyssikatos, Joseph P.

ACS Med Chem Lett; 5(1): 78-83, 2014 Jan 09.

Artículo en Inglés | MEDLINE | ID: mdl-24900776

11.

5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.

Bach, Peter; Boström, Jonas; Brickmann, Kay; Burgess, Laurence E; Clarke, David; Groneberg, Robert D; Harvey, Darren M; Laird, Ellen R; O'Sullivan, Michael; Zetterberg, Fredrik.

Future Med Chem; 5(17): 2037-56, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-24215345

12.

Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.

Eary, C Todd; Jones, Zachary S; Groneberg, Robert D; Burgess, Laurence E; Mareska, David A; Drew, Mark D; Blake, James F; Laird, Ellen R; Balachari, Devan; O'Sullivan, Michael; Allen, Andrew; Marsh, Vivienne.

Bioorg Med Chem Lett; 17(9): 2608-13, 2007 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-17331716

13.

Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists.

Allen, Shelley; Newhouse, Bradley; Anderson, Aaron S; Fauber, Benjamin; Allen, Andrew; Chantry, David; Eberhardt, Christine; Odingo, Joshua; Burgess, Laurence E.

Bioorg Med Chem Lett; 14(7): 1619-24, 2004 Apr 05.

Artículo en Inglés | MEDLINE | ID: mdl-15026036

14.

Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.

Newhouse, Bradley; Allen, Shelley; Fauber, Benjamin; Anderson, Aaron S; Eary, C Todd; Hansen, Joshua D; Schiro, Justin; Gaudino, John J; Laird, Ellen; Chantry, David; Eberhardt, Christine; Burgess, Laurence E.

Bioorg Med Chem Lett; 14(22): 5537-42, 2004 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-15482919

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