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1.
High π-Facial and exo-Selectivity for the Intramolecular Diels-Alder Cycloaddition of Dodeca-3,9,11-trien-5-one Precursors to 2-epi-Symbioimine and Related Compounds.
J Org Chem;
81(18): 8508-19, 2016 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27563727
2.
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.
Bioorg Med Chem Lett;
21(1): 463-6, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21074994
3.
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J Med Chem;
64(20): 15141-15169, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34643390
4.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem;
64(15): 11302-11329, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34292726
5.
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
J Med Chem;
63(17): 9888-9911, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787110
6.
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib.
Cancer Res;
80(21): 4840-4853, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32928921
7.
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
J Med Chem;
63(21): 12957-12977, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33118821
8.
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
Angew Chem Int Ed Engl;
51(25): 6140-3, 2012 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-22566140
9.
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.
J Med Chem;
58(9): 3794-805, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25844895
10.
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J Med Chem;
56(1): 15-30, 2013 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-23244564
11.
Exploring the original proposed biosynthesis of (+)-symbioimine: remote exocyclic stereocontrol in a type I IMDA reaction.
Org Lett;
12(14): 3192-5, 2010 Jul 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-20550217
12.
Synthesis and application of chiral cyclopropane-based ligands in palladium-catalyzed allylic alkylation.
J Org Chem;
69(23): 8062-9, 2004 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-15527291
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