The complexity of spontaneous brain activity changes in schizophrenia, bipolar disorder, and ADHD was examined using different variations of entropy.

Adult attention deficit/hyperactivity disorder (ADHD), schizophrenia (SCHZ), and bipolar disorder (BP) have common symptoms and differences, and the underlying neural mechanisms are still unclear. This article will thoroughly discuss the differences between ADHD, BP, and SCHZ (31 healthy control and 31 ADHD; 34 healthy control and 34 BP; 42 healthy control and 42 SCHZ) relative to healthy subjects in combination with three atlases (et al., the Brainnetome atlas, the Dosenbach atlas, the Power atlas) and seven entropies (et al., approximate entropy (ApEn), sample entropy (SaEn), permutation entropy (PeEn), fuzzy entropy (FuEn), differential entropy (DiffEn), range entropy (RaEn), and dispersion entropy (DispEn)), as well as the prominent significant brain regions, in the hope of giving information that is more suitable for analyzing different diseases' entropy. First, the reliability (et al., intraclass correlation coefficient [ICC]) of seven kinds of entropy is calculated and analyzed by using the MSC dataset (10 subjects and 100 sessions in total) and simulation data; then, seven types of entropy and multiscale entropy expanded based on seven kinds of entropy are used to explore the differences and brain regions of ADHD, BP, and SCHZ relative to healthy subjects; and finally, by verifying the classification performance of the seven information entropies on ADHD, BP, and SCHZ, the effectiveness of the seven entropy methods is evaluated through these three methods. The core brain regions that affect the classification are given, and DiffEn performed best on ADHD, SaEn for BP, and RaEn for SCHZ.

Global Network Analysis of Alzheimer's Disease with Minimum Spanning Trees.

BACKGROUND: A minimum spanning tree (MST) is a unique efficient network comprising the necessary connections needed to connect all regions in a network while retaining the lowest possible cost of connection weight. OBJECTIVE: This study aimed to utilize functional near-infrared spectroscopy (fNIRS) to analyze brain activity in different regions and then construct MST-based regions to characterize the brain topologies of participants with Alzheimer's disease (AD), mild cognitive impairment (MCI), and normal controls (NC). METHODS: A 46 channel fNIRS setup was used on all participants, with correlation being calculated for each channel pair. An MST was constructed from the resulting correlation matrix, from which graph theory measures were calculated. The average number of connections within a lobe in the left versus right hemisphere was calculated to identify which lobes displayed and abnormal amount of connectivity. RESULTS: Compared to those in the MCI group, the AD group showed a less integrated network structure, with a higher characteristic path length, but lower leaf fraction, maximum degree, and degree divergence. The AD group also showed a higher number of connections in the frontal lobe within the left hemisphere and a lower number between hemispheric frontal lobes as compared to MCI. CONCLUSION: These results indicate a deviation in network structure and connectivity within patient groups that is consistent with the theory of dysconnectivity for AD. Additionally, the AD group showed strong correlations between the Hamilton depression rating scale and different graph metrics, suggesting a link between network organization and the recurrence of depression in AD.

A review of resting-state fMRI and its use to examine psychiatric disorders.

Resting-state fMRI (rs-fMRI) has emerged as an alternative method to study brain function in human and animal models. In humans, it has been widely used to study psychiatric disorders including schizophrenia, bipolar disorder, autism spectrum disorders, and attention deficit hyperactivity disorders. In this review, rs-fMRI and its advantages over task based fMRI, its currently used analysis methods, and its application in psychiatric disorders using different analysis methods are discussed. Finally, several limitations and challenges of rs-fMRI applications are also discussed.