The analgesic properties of delta-9-tetrahydrocannabinol and codeine.

The administration of single oral doses of delta-9-tetrahydrocannabinol (THC) to patients with cancer pain demonstrated a mild analgesic effect. At a dose of 20 mg, however, THC induced side effects that would prohibit its therapeutic use including somnolence, dizziness, ataxia, and blurred vision. Alarming adverse reactions were also observed at this dose. THC, 10 mg, was well tolerated and, despite its sedative effect, may analgesic potential.

Analgesic effect of delta-9-tetrahydrocannabinol.

A preliminary trial of oral delta-9-tetrahydrocannabinol (THC) demonstrated an analgesic effect of the drug in patients experiencing cancer pain. Placebo and 5, 10, 15, and 20 mg THC were administered double blind to ten patients. Pain relief significantly superior to placebo was demonstrated at high dose levels (15 and 20 mg). At these levels, substantial sedation and mental clouding were reported.

A comparison of EMG feedback and progressive muscle relaxation training in anxiety neurosis.

Two similar groups of adult psychiatric patients carrying the diagnosis of anxiety neurosis were compared in their response to different methods of training in deep muscle relaxation. One group received EMG feedback and the other a modification of the Jacobson Progressive Relaxation method. The frontalis muscle was chosen as the target for feedback training and for the measurement of tension reduction in both groups, for the reason that this muscle has been shown to reflect the general muscle tension level in anxious patients. Training was carried out under controlled laboratory conditions, and objective muscle tension levels were obtained. Overall changes in the status of the anxiety symptoms, as determined by global ratings from patients and from primary therapists, were also compared in the two groups at the end of training. The results of the study indicated that both EMG feedback and the progressive muscle relaxation training produced significant reductions in frontalis tension levels. However, EMG feedback was found to be generally superior in producing larger reductions in muscle activity, with a concomitant relief in anxiety symptoms, for a greater number of the patients.

Stressful life events and burn injuries.

About half of the 67 adults admitted to a burn treatment unit during the course of a year were found to have pre-existing physical and/or psychiatric conditions that increased their susceptibility to injury. In addition, the majority of victims were unmarried, unemployed, and came from low social class, circumstances that tended to increase their vulnerability. A significant increase in stressful life events was reported by these patients during the year preceding burn injury. This life change was negatively correlated with age, income, and number of friends, and positively correlated with social class and psychiatric illness. Two subgroups of persons vulnerable to burns were identified, the first, older women with physical illness, and the second, persons of low social class with psychiatric disorders. The findings have implications for burn prevention and rehabilitation of burn victims.