1.
Bioorg Med Chem Lett
; 17(2): 315-9, 2007 Jan 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17118655
RESUMEN
Alpha-methyltryptamine sulfonamides were identified as human glucocorticoid receptor (hGR) ligands in an ultra high throughput screening (UHTS) campaign. Described will be the hit-to-lead activities, including parallel and single point analog synthesis to map the scaffold. Ligands were identified that exhibited 30 nM binding to hGR. The SAR and selectivity of these compounds will be discussed.