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1.

Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS): A Multiplexed Microarray Platform for Targeted Proteomics.

Hamza, Ghaith M; Bergo, Vladislav B; Mamaev, Sergey; Wojchowski, Don M; Toran, Paul; Worsfold, Camilla R; Castaldi, M Paola; Silva, Jeffrey C.

Int J Mol Sci; 21(6)2020 Mar 16.

Artículo en Inglés | MEDLINE | ID: mdl-32188029

2.

Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit.

Kawatkar, Aarti; Clark, Roger A; Hopcroft, Lorna; Roaquin, Debora Ann; Tomlinson, Ronald; Zuhl, Andrea M; Lamont, Gillian M; Kettle, Jason G; Critchlow, Susan E; Castaldi, M Paola; Goldberg, Frederick W; Zhang, Andrew X.

ACS Chem Biol; 18(2): 296-303, 2023 02 17.

Artículo en Inglés | MEDLINE | ID: mdl-36602435

3.

Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners.

Doshi, Aatman S; Cantin, Susan; Hernandez, Marylens; Srinivasan, Srimathi; Tentarelli, Sharon; Griffin, Matthew; Wang, Yanjun; Pop-Damkov, Petar; Prickett, Laura B; Kankkonen, Cecilia; Shen, Minhui; Martin, Maryann San; Wu, Song; Castaldi, M Paola; Ghadially, Hormas; Varnes, Jeffrey; Gales, Sonya; Henry, David; Hoover, Clare; Mele, Deanna A; Simpson, Iain; Gangl, Eric T; Mlynarski, Scott N; Finlay, M Raymond V; Drew, Lisa; Fawell, Stephen E; Shao, Wenlin; Schuller, Alwin G.

Mol Cancer Ther; 22(5): 630-645, 2023 05 04.

Artículo en Inglés | MEDLINE | ID: mdl-36912782

4.

Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.

Wrobel, Lidia; Hill, Sandra M; Djajadikerta, Alvin; Fernandez-Estevez, Marian; Karabiyik, Cansu; Ashkenazi, Avraham; Barratt, Victoria J; Stamatakou, Eleanna; Gunnarsson, Anders; Rasmusson, Timothy; Miele, Eric W; Beaton, Nigel; Bruderer, Roland; Feng, Yuehan; Reiter, Lukas; Castaldi, M Paola; Jarvis, Rebecca; Tan, Keith; Bürli, Roland W; Rubinsztein, David C.

Nat Commun; 13(1): 4146, 2022 07 16.

Artículo en Inglés | MEDLINE | ID: mdl-35842429

5.

Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods.

Hendricks, J Adam; Beaton, Nigel; Chernobrovkin, Alexey; Miele, Eric; Hamza, Ghaith M; Ricchiuto, Piero; Tomlinson, Ronald C; Friman, Tomas; Borenstain, Cassandra; Barlaam, Bernard; Hande, Sudhir; Lamb, Michelle L; De Savi, Chris; Davies, Rick; Main, Martin; Hellner, Joakim; Beeler, Kristina; Feng, Yuehan; Bruderer, Roland; Reiter, Lukas; Molina, Daniel Martinez; Castaldi, M Paola.

ACS Chem Biol; 17(1): 54-67, 2022 01 21.

Artículo en Inglés | MEDLINE | ID: mdl-34955012

6.

Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.

Parsons, Jerod; Castaldi, M Paola; Dutta, Sanjay; Dibrov, Sergey M; Wyles, David L; Hermann, Thomas.

Nat Chem Biol; 5(11): 823-5, 2009 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-19767736

7.

Proteolysis-targeting chimeras in drug development: A safety perspective.

Moreau, Kevin; Coen, Muireann; Zhang, Andrew X; Pachl, Fiona; Castaldi, M Paola; Dahl, Goran; Boyd, Helen; Scott, Clay; Newham, Pete.

Br J Pharmacol; 177(8): 1709-1718, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32022252

8.

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.

Hsu, Jessie Hao-Ru; Rasmusson, Timothy; Robinson, James; Pachl, Fiona; Read, Jon; Kawatkar, Sameer; O' Donovan, Daniel H; Bagal, Sharan; Code, Erin; Rawlins, Philip; Argyrou, Argyrides; Tomlinson, Ronald; Gao, Ning; Zhu, Xiahui; Chiarparin, Elisabetta; Jacques, Kelly; Shen, Minhui; Woods, Haley; Bednarski, Emma; Wilson, David M; Drew, Lisa; Castaldi, M Paola; Fawell, Stephen; Bloecher, Andrew.

Cell Chem Biol; 27(1): 41-46.e17, 2020 01 16.

Artículo en Inglés | MEDLINE | ID: mdl-31786184

9.

CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins.

Kawatkar, Aarti; Schefter, Michelle; Hermansson, Nils-Olov; Snijder, Arjan; Dekker, Niek; Brown, Dean G; Lundbäck, Thomas; Zhang, Andrew X; Castaldi, M Paola.

ACS Chem Biol; 14(9): 1913-1920, 2019 09 20.

Artículo en Inglés | MEDLINE | ID: mdl-31329413

10.

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.

Stefaniak, Jakub; Lewis, Andrew M; Conole, Daniel; Galan, Sébastien R G; Bataille, Carole J R; Wynne, Graham M; Castaldi, M Paola; Lundbäck, Thomas; Russell, Angela J; Huber, Kilian V M.

ACS Chem Biol; 13(10): 2849-2854, 2018 10 19.

Artículo en Inglés | MEDLINE | ID: mdl-30216042

11.

Modulating Antibody Structure and Function through Directed Mutations and Chemical Rescue.

Kaiser, Christine E; Rincon Pabon, Juan Pablo; Khowsathit, Jittasak; Castaldi, M Paola; Kazmirski, Steven L; Weis, David D; Zhang, Andrew X; Karanicolas, John.

ACS Synth Biol; 7(4): 1152-1162, 2018 04 20.

Artículo en Inglés | MEDLINE | ID: mdl-29609459

12.

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

McCoull, William; Cheung, Tony; Anderson, Erica; Barton, Peter; Burgess, Jonathan; Byth, Kate; Cao, Qing; Castaldi, M Paola; Chen, Huawei; Chiarparin, Elisabetta; Carbajo, Rodrigo J; Code, Erin; Cowan, Suzanna; Davey, Paul R; Ferguson, Andrew D; Fillery, Shaun; Fuller, Nathan O; Gao, Ning; Hargreaves, David; Howard, Martin R; Hu, Jun; Kawatkar, Aarti; Kemmitt, Paul D; Leo, Elisabetta; Molina, Daniel M; O'Connell, Nichole; Petteruti, Philip; Rasmusson, Timothy; Raubo, Piotr; Rawlins, Philip B; Ricchiuto, Piero; Robb, Graeme R; Schenone, Monica; Waring, Michael J; Zinda, Michael; Fawell, Stephen; Wilson, David M.

ACS Chem Biol; 13(11): 3131-3141, 2018 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-30335946

13.

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

Koundinya, Malvika; Sudhalter, Judith; Courjaud, Albane; Lionne, Bruno; Touyer, Gaetan; Bonnet, Luc; Menguy, Isabelle; Schreiber, Isabelle; Perrault, Christelle; Vougier, Stephanie; Benhamou, Brigitte; Zhang, Bailin; He, Timothy; Gao, Qiang; Gee, Patricia; Simard, Daniel; Castaldi, M Paola; Tomlinson, Ronald; Reiling, Stephan; Barrague, Matthieu; Newcombe, Richard; Cao, Hui; Wang, Yanjun; Sun, Fangxian; Murtie, Joshua; Munson, Mark; Yang, Eric; Harper, David; Bouaboula, Monsif; Pollard, Jack; Grepin, Claudine; Garcia-Echeverria, Carlos; Cheng, Hong; Adrian, Francisco; Winter, Christopher; Licht, Stuart; Cornella-Taracido, Ivan; Arrebola, Rosalia; Morris, Aaron.

Cell Chem Biol; 25(6): 705-717.e11, 2018 06 21.

Artículo en Inglés | MEDLINE | ID: mdl-29628435

14.

Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.

Casás-Selves, Matias; Zhang, Andrew X; Dowling, James E; Hallén, Stefan; Kawatkar, Aarti; Pace, Nicholas J; Denz, Christopher R; Pontz, Timothy; Garahdaghi, Farzin; Cao, Qing; Sabirsh, Alan; Thakur, Kumar; O'Connell, Nichole; Hu, Jun; Cornella-Taracido, Iván; Weerapana, Eranthie; Zinda, Michael; Goodnow, Robert A; Castaldi, M Paola.

ChemMedChem; 12(12): 917-924, 2017 06 21.

Artículo en Inglés | MEDLINE | ID: mdl-28371485

15.

Applications of chiral C3-symmetric molecules.

Gibson, Susan E; Castaldi, M Paola.

Chem Commun (Camb); (29): 3045-62, 2006 Aug 07.

Artículo en Inglés | MEDLINE | ID: mdl-16855685

16.

Advances in Protein Degradation.

Castaldi, M Paola; Fisher, Stewart L.

SLAS Discov; 26(4): 471-473, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33780295

17.

C3 symmetry: molecular design inspired by nature.

Gibson, Susan E; Castaldi, M Paola.

Angew Chem Int Ed Engl; 45(29): 4718-20, 2006 Jul 17.

Artículo en Inglés | MEDLINE | ID: mdl-16795111

18.

Introduction of multiple elements of chirality around an aromatic core and an approach to enantiomerically pure C3-symmetric ligands.

Castaldi, M Paola; Gibson, Susan E; Rudd, Matthew; White, Andrew J P.

Angew Chem Int Ed Engl; 44(22): 3432-5, 2005 May 30.

Artículo en Inglés | MEDLINE | ID: mdl-15861451

19.

Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.

Castaldi, M Paola; Troast, Dawn M; Porco, John A.

Org Lett; 11(15): 3362-5, 2009 Aug 06.

Artículo en Inglés | MEDLINE | ID: mdl-19719184

20.

A new approach to enantiopure C3-symmetric molecules.