Measurement-Device-Independent Entanglement Detection for Continuous-Variable Systems.

We study the detection of continuous-variable entanglement, for which most of the existing methods designed so far require a full specification of the devices, and we present protocols for entanglement detection in a scenario where the measurement devices are completely uncharacterized. We first generalize, to the continuous variable regime, the seminal results by Buscemi [Phys. Rev. Lett. 108, 200401 (2012)PRLTAO0031-900710.1103/PhysRevLett.108.200401] and Branciard et al. [Phys. Rev. Lett. 110, 060405 (2013)PRLTAO0031-900710.1103/PhysRevLett.110.060405], showing that all entangled states can be detected in this scenario. Most importantly, we then describe a practical protocol that allows for the measurement-device-independent certification of entanglement of all two-mode entangled Gaussian states. This protocol is feasible with current technology as it makes use only of standard optical setups such as coherent states and homodyne measurements.

Statistical Properties of the Quantum Internet.

Steady technological advances are paving the way for the implementation of the quantum internet, a network of locations interconnected by quantum channels. Here we propose a model to simulate a quantum internet based on optical fibers and employ network-theory techniques to characterize the statistical properties of the photonic networks it generates. Our model predicts a continuous phase transition between a disconnected and a highly connected phase and that the typical photonic networks do not present the small world property. We compute the critical exponents characterizing the phase transition, provide quantitative estimates for the minimum density of nodes needed to have a fully connected network and for the average distance between nodes. Our results thus provide quantitative benchmarks for the development of a quantum internet.

All Sets of Incompatible Measurements give an Advantage in Quantum State Discrimination.

Some quantum measurements cannot be performed simultaneously; i.e., they are incompatible. Here we show that every set of incompatible measurements provides an advantage over compatible ones in a suitably chosen quantum state discrimination task. This is proven by showing that the robustness of incompatibility, a quantifier of how much noise a set of measurements tolerates before becoming compatible, has an operational interpretation as the advantage in an optimally chosen discrimination task. We also show that if we take a resource-theory perspective of measurement incompatibility, then the guessing probability in discrimination tasks of this type forms a complete set of monotones that completely characterize the partial order in the resource theory. Finally, we make use of previously known relations between measurement incompatibility and Einstein-Podolsky-Rosen steering to also relate the latter with quantum state discrimination.

Device-Independent Tests of Structures of Measurement Incompatibility.

In contrast with classical physics, in quantum physics some sets of measurements are incompatible in the sense that they cannot be performed simultaneously. Among other applications, incompatibility allows for contextuality and Bell nonlocality. This makes it of crucial importance to develop tools for certifying whether a set of measurements respects a certain structure of incompatibility. Here we show that, for quantum or nonsignaling models, if the measurements employed in a Bell test satisfy a given type of compatibility, then the amount of violation of some specific Bell inequalities becomes limited. Then, we show that correlations arising from local measurements on two-qubit states violate these limits, which rules out in a device-independent way such structures of incompatibility. In particular, we prove that quantum correlations allow for a device-independent demonstration of genuine triplewise incompatibility. Finally, we translate these results into a semidevice-independent Einstein-Podolsky-Rosen-steering scenario.

Bounding the Sets of Classical and Quantum Correlations in Networks.

We present a method that allows the study of classical and quantum correlations in networks with causally independent parties, such as the scenario underlying entanglement swapping. By imposing relaxations of factorization constraints in a form compatible with semidefinite programing, it enables the use of the Navascués-Pironio-Acín hierarchy in complex quantum networks. We first show how the technique successfully identifies correlations not attainable in the entanglement-swapping scenario. Then we use it to show how the nonlocal power of measurements can be activated in a network: there exist measuring devices that, despite being unable to generate nonlocal correlations in the standard Bell scenario, provide a classical-quantum separation in an entanglement swapping configuration.

Enhanced Multiqubit Phase Estimation in Noisy Environments by Local Encoding.

The first generation of multiqubit quantum technologies will consist of noisy, intermediate-scale devices for which active error correction remains out of reach. To exploit such devices, it is thus imperative to use passive error protection that meets a careful trade-off between noise protection and resource overhead. Here, we experimentally demonstrate that single-qubit encoding can significantly enhance the robustness of entanglement and coherence of four-qubit graph states against local noise with a preferred direction. In particular, we explicitly show that local encoding provides a significant practical advantage for phase estimation in noisy environments. This demonstrates the efficacy of local unitary encoding under realistic conditions, with potential applications in multiqubit quantum technologies for metrology, multipartite secrecy, and error correction.

Maximal Randomness Generation from Steering Inequality Violations Using Qudits.

We consider the generation of randomness based upon the observed violation of an Einstein-Podolsky-Rosen (EPR) steering inequality, known as one-sided device-independent randomness generation. We show that in the simplest scenario-involving only two parties and two measurements for the uncharacterised party with d outcomes-that there exist EPR steering inequalities whose maximal violation certifies maximal randomness generation, equal to log(d) bits. We further show that all pure partially entangled full-Schmidt-rank states in all dimensions can achieve maximal violation of these inequalities, and thus lead to maximal randomness generation in the one-sided device-independent setting. More generally, the amount of randomness that can be generated is given by a semidefinite program, which we use to study the behavior for nonmaximal violations of the inequalities.

Device-Independent Entanglement Certification of All Entangled States.

We present a method to certify the entanglement of all entangled quantum states in a device-independent way. This is achieved by placing the state in a quantum network and constructing a correlation inequality based on an entanglement witness for the state. Our method is device independent, in the sense that entanglement can be certified from the observed statistics alone, under minimal assumptions on the underlying physics. Conceptually, our results borrow ideas from the field of self-testing to bring the recently introduced measurement-device-independent entanglement witnesses into the fully device-independent regime.

Experimental Study of Nonclassical Teleportation Beyond Average Fidelity.

Quantum teleportation establishes a correspondence between an entangled state shared by two separate parties that can communicate classically and the presence of a quantum channel connecting the two parties. The standard benchmark for quantum teleportation, based on the average fidelity between the input and output states, indicates that some entangled states do not lead to channels which can be certified to be quantum. It was recently shown that if one considers a finer-grained witness, then all entangled states can be certified to produce a nonclassical teleportation channel. Here we experimentally demonstrate a complete characterization of a new family of such witnesses, of the type proposed in Phys. Rev. Lett. 119, 110501 (2017)PRLTAO0031-900710.1103/PhysRevLett.119.110501 under different conditions of noise. We report nonclassical teleportation using quantum states that cannot achieve average fidelity of teleportation above the classical limit. We further use the violation of these witnesses to estimate the negativity of the shared state. Our results have fundamental implications in quantum information protocols and may also lead to new applications and quality certification of quantum technologies.

All Entangled States can Demonstrate Nonclassical Teleportation.

Quantum teleportation, the process by which Alice can transfer an unknown quantum state to Bob by using preshared entanglement and classical communication, is one of the cornerstones of quantum information. The standard benchmark for certifying quantum teleportation consists in surpassing the maximum average fidelity between the teleported and the target states that can be achieved classically. According to this figure of merit, not all entangled states are useful for teleportation. Here we propose a new benchmark that uses the full information available in a teleportation experiment and prove that all entangled states can implement a quantum channel which cannot be reproduced classically. We introduce the idea of nonclassical teleportation witness to certify if a teleportation experiment is genuinely quantum and discuss how to quantify this phenomenon. Our work provides new techniques for studying teleportation that can be immediately applied to certify the quality of quantum technologies.

Erratum: All Entangled States Can Demonstrate Nonclassical Teleportation [Phys. Rev. Lett. 119, 110501 (2017)].

This corrects the article DOI: 10.1103/PhysRevLett.119.110501.

Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

Hierarchy of Steering Criteria Based on Moments for All Bipartite Quantum Systems.

Einstein-Podolsky-Rosen steering is a manifestation of quantum correlations exhibited by quantum systems that allows for entanglement certification when one of the subsystems is not characterized. Detecting the steerability of quantum states is essential to assess their suitability for quantum information protocols with partially trusted devices. We provide a hierarchy of sufficient conditions for the steerability of bipartite quantum states of any dimension, including continuous variable states. Previously known steering criteria are recovered as special cases of our approach. The proposed method allows us to derive optimal steering witnesses for arbitrary families of quantum states and provides a systematic framework to analytically derive nonlinear steering criteria. We discuss relevant examples and, in particular, provide an optimal steering witness for a lossy single-photon Bell state; the witness can be implemented just by linear optics and homodyne detection and detects steering with a higher loss tolerance than any other known method. Our approach is readily applicable to multipartite steering detection and to the characterization of joint measurability.

Postquantum Steering.

The discovery of postquantum nonlocality, i.e., the existence of nonlocal correlations that are stronger than any quantum correlations but nevertheless consistent with the no-signaling principle, has deepened our understanding of the foundations of quantum theory. In this work, we investigate whether the phenomenon of Einstein-Podolsky-Rosen steering, a different form of quantum nonlocality, can also be generalized beyond quantum theory. While post-quantum steering does not exist in the bipartite case, we prove its existence in the case of three observers. Importantly, we show that postquantum steering is a genuinely new phenomenon, fundamentally different from postquantum nonlocality. Our results provide new insight into the nonlocal correlations of multipartite quantum systems.

Quantifying Einstein-Podolsky-Rosen steering.

Einstein-Podolsky-Rosen steering is a form of bipartite quantum correlation that is intermediate between entanglement and Bell nonlocality. It allows for entanglement certification when the measurements performed by one of the parties are not characterized (or are untrusted) and has applications in quantum key distribution. Despite its foundational and applied importance, Einstein-Podolsky-Rosen steering lacks a quantitative assessment. Here we propose a way of quantifying this phenomenon and use it to study the steerability of several quantum states. In particular, we show that every pure entangled state is maximally steerable and the projector onto the antisymmetric subspace is maximally steerable for all dimensions; we provide a new example of one-way steering and give strong support that states with positive-partial transposition are not steerable.

Potential application of a handheld confocal endomicroscope imaging system using a variety of fluorophores in experimental gliomas and normal brain.

OBJECT: The authors sought to assess the feasibility of a handheld visible-wavelength confocal endomicroscope imaging system (Optiscan 5.1, Optiscan Pty., Ltd.) using a variety of rapid-acting fluorophores to provide histological information on gliomas, tumor margins, and normal brain in animal models. METHODS: Mice (n = 25) implanted with GL261 cells were used to image fluorescein sodium (FNa), 5-aminolevulinic acid (5-ALA), acridine orange (AO), acriflavine (AF), and cresyl violet (CV). A U251 glioma xenograft model in rats (n = 5) was used to image sulforhodamine 101 (SR101). A swine (n = 3) model with AO was used to identify confocal features of normal brain. Images of normal brain, obvious tumor, and peritumoral zones were collected using the handheld confocal endomicroscope. Histological samples were acquired through biopsies from matched imaging areas. Samples were visualized with a benchtop confocal microscope. Histopathological features in corresponding confocal images and photomicrographs of H & E-stained tissues were reviewed. RESULTS: Fluorescence induced by FNa, 5-ALA, AO, AF, CV, and SR101 and detected with the confocal endomicroscope allowed interpretation of histological features. Confocal endomicroscopy revealed satellite tumor cells within peritumoral tissue, a definitive tumor border, and striking fluorescent cellular and subcellular structures. Fluorescence in various tumor regions correlated with standard histology and known tissue architecture. Characteristic features of different areas of normal brain were identified as well. CONCLUSIONS: Confocal endomicroscopy provided rapid histological information precisely related to the site of microscopic imaging with imaging characteristics of cells related to the unique labeling features of the fluorophores. Although experimental with further clinical trial validation required, these data suggest that intraoperative confocal imaging can help to distinguish normal brain from tumor and tumor margin and may have application in improving intraoperative decisions during resection of brain tumors.

Comparative analysis of isocentric 3-dimensional C-arm fluoroscopy and biplanar fluoroscopy for anterior screw fixation in odontoid fractures.

STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To compare long-term radiographic and clinical outcomes of patients undergoing anterior odontoid screw placement using traditional biplanar fluoroscopy or isocentric 3-dimensional C-arm (iso-C) fluoroscopy-assisted techniques. SUMMARY OF BACKGROUND DATA: Anterior screw fixation of odontoid fractures preserves motion at the C1-C2 joint, but accurate screw positioning is essential for successful outcomes. Biplanar fluoroscopy image guidance is most often used; however, iso-C imaging improves the ease and accuracy of screw placement with less radiation exposure. METHODS: Fifty-one patients underwent anterior odontoid screw fixation for type II (48 patients) and rostral type III fractures (3 patients). Procedures were guided by biplanar fluoroscopy in 25 (49%) patients, and with iso-C assistance in 26 (51%). Length of surgery, complications, and clinical outcomes based on the Smiley-Webster score were evaluated. Computed tomography confirmed adequate screw placement. Follow-up ranged from 3 to 9 months. RESULTS: At 3-month follow-up, screw position and fusion across the fracture were evident in 87% of the cases treated with biplanar fluoroscopy and in 100% treated by iso-C. The average outcome score in the iso-C group was superior to that of the biplanar group (1.08 vs. 1.33, respectively), although not statistically significant. At last follow-up, the rate of successful fusion was 88% in the biplanar group and 95% in the iso-C group. Length of surgery was significantly lower in the iso-C group compared with the biplanar group (P=0.05). The significantly longer preparation time in the iso-C group (P=0.04) accounted for no overall difference in total operating room occupancy time between the 2 groups. CONCLUSIONS: Iso-C significantly decreased surgical time. At last follow-up iso-C assistance was associated with improved rates of radiographic fusion with comparable outcome and complication profiles. This series represents the largest cohort of patients treated with intraoperative real-time navigation assistance for odontoid fractures.

Nonlocality tests enhanced by a third observer.

We consider Bell tests involving bipartite states shared between three parties. We show that the simple inclusion of a third part may greatly simplify the measurement scenario (in terms of the number of measurement settings per part) and allows the identification of previously unknown nonlocal resources.

Development and Mechanical Characterization of Short Curauá Fiber-Reinforced PLA Composites Made via Fused Deposition Modeling.

The increase in the use of additive manufacturing (AM) has led to the need for filaments with specific and functional properties in face of requirements of structural parts production. The use of eco-friendly reinforcements (i.e., natural fibers) as an alternative to those more traditional synthetic counterparts is still scarce and requires further investigation. The main objective of this work was to develop short curauá fiber-reinforced polylactic acid (PLA) composites made via fused deposition modeling. Three different fiber lengths (3, 6, and 8 mm), and three concentrations in terms of weight percentage (2, 3.5, and 5 wt.%) were used to fabricate reinforced PLA filaments. Tensile and flexural tests in accordance with their respective American Society for Testing and Materials (ASTM) standards were performed. A thermal analysis was also carried out in order to investigate the thermal stability of the new materials. It was found that the main driving factor for the variation in mechanical properties was the fiber weight fraction. The increase in fiber length did not provide any significant benefit on the mechanical properties of the curauá fiber-reinforced PLA composite printed parts. The composites produced with PLA filaments reinforced by 3 mm 2% curauá fiber presented the overall best mechanical and thermal properties of all studied groups. The curauá fiber-reinforced PLA composites made via fused deposition modeling may be a promising innovation to improve the performance of these materials, which might enable them to serve for new applications.

Avoiding the Radial Paradox: Neuroendovascular Femoral Access Outcomes After Radial Access Adoption.

BACKGROUND: Transradial access (TRA) for neuroendovascular procedures is increasing in prevalence. The safety benefits of TRA at a patient level may be offset at a population level by a paradoxical increase in transfemoral access (TFA) vascular access site complications (VASCs), the so-called "radial paradox." OBJECTIVE: To study the effect of TRA adoption on TFA performance and outcomes in neuroendovascular procedures. METHODS: Data were collected for all procedures performed over a 10-mo period after radial adoption at a single center. RESULTS: Over the study period, 1084 procedures were performed, including 719 (66.3%) with an intent to treat by TRA and 365 (33.7%) with an intent to treat by TFA. Thirty-two cases (4.4%) crossed over from TRA to TFA, and 2 cases (0.5%) crossed over from TFA to TRA. TFA was performed in older patients (mean [standard deviation] TFA, 63 [15] vs TRA, 56 [16] years) using larger sheath sizes (≥7 French; TFA, 56.2% vs TRA, 2.3%) ( P < .001 for both comparisons). Overall, 29 VASCs occurred (2.7%), including 27 minor (TFA, 4.6% [18/395] vs TRA, 1.3% [9/689], P = .002) and 2 major (TFA, 0.3% [1/395] vs TRA, 0.1% [1/689], P > .99) complications. Independent predictors of VASC included TFA (OR 2.8, 95% confidence interval [CI] 1.1-7.4) and use of dual antiplatelet therapy (OR 4.2, 95% CI 1.6-11.1). CONCLUSION: TFA remains an important access route, despite a predominantly radial paradigm, and is disproportionately used in patients at increased risk for VASCs. TFA proficiency may still be achieved in predominantly radial practices without an increase in femoral complications.