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1.

PCSK9 and the nervous system: a no-brainer?

Jaafar, Ali K; Techer, Romuald; Chemello, Kévin; Lambert, Gilles; Bourane, Steeve.

J Lipid Res; 64(9): 100426, 2023 09.

Artículo en Inglés | MEDLINE | ID: mdl-37586604

2.

Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study.

Begue, Floran; Chemello, Kévin; Veeren, Bryan; Lortat-Jacob, Brice; Tran-Dinh, Alexy; Zappella, Nathalie; Snauwaert, Aurelie; Robert, Tiphaine; Rondeau, Philippe; Lagrange-Xelot, Marie; Montravers, Philippe; Couret, David; Tanaka, Sébastien; Meilhac, Olivier.

Int J Mol Sci; 24(5)2023 Feb 27.

Artículo en Inglés | MEDLINE | ID: mdl-36902035

3.

A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo.

Suchowerska, Alexandra K; Stokman, Geurt; Palmer, James T; Coghlan, Phillip A; Pieterman, Elsbet J; Keijzer, Nanda; Lambert, Gilles; Chemello, Kevin; Jaafar, Ali K; Parmar, Jasneet; Yan, Liping; Tong, Yingtao; Mu, Lin; Princen, Hans M G; Bonnar, James; Evison, Benny J.

J Lipid Res; 63(11): 100293, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-36209894

4.

Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes.

Croyal, Mikaël; Wargny, Matthieu; Chemello, Kevin; Chevalier, Chloé; Blanchard, Valentin; Bigot-Corbel, Edith; Lambert, Gilles; Le May, Cédric; Hadjadj, Samy; Cariou, Bertrand.

Cardiovasc Diabetol; 21(1): 21, 2022 02 07.

Artículo en Inglés | MEDLINE | ID: mdl-35130909

5.

Genetic and Mechanistic Insights into the Modulation of Circulating Lipoprotein (a) Concentration by Apolipoprotein E Isoforms.

Chemello, Kévin; Blom, Dirk J; Marais, A David; Lambert, Gilles; Blanchard, Valentin.

Curr Atheroscler Rep; 24(6): 399-405, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-35355214

6.

Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.

Huijgen, Roeland; Blom, Dirk J; Hartgers, Merel L; Chemello, Kévin; Benito-Vicente, Asier; Uribe, Kepa B; Behardien, Zorena; Blackhurst, Dee M; Brice, Brigitte C; Defesche, Joep C; de Jong, Annemiek G; Jooste, Rosemary J; Solomon, Gabriele A E; Wolmarans, Karen H; Hovingh, G Kees; Martin, Cesar; Lambert, Gilles; Marais, A David.

Arterioscler Thromb Vasc Biol; 41(2): 934-943, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33147992

7.

Lipoprotein metabolism in familial hypercholesterolemia.

Chemello, Kévin; García-Nafría, Javier; Gallo, Antonio; Martín, Cesar; Lambert, Gilles; Blom, Dirk.

J Lipid Res; 62: 100062, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33675717

8.

A Systematic Approach to Assess the Activity and Classification of PCSK9 Variants.

Uribe, Kepa B; Chemello, Kevin; Larrea-Sebal, Asier; Benito-Vicente, Asier; Galicia-Garcia, Unai; Bourane, Steeve; Jaafar, Ali K; Lambert, Gilles; Martín, César.

Int J Mol Sci; 22(24)2021 Dec 18.

Artículo en Inglés | MEDLINE | ID: mdl-34948399

9.

A high-throughput mass spectrometry-based assay for large-scale profiling of circulating human apolipoproteins.

Blanchard, Valentin; Garçon, Damien; Jaunet, Catherine; Chemello, Kevin; Billon-Crossouard, Stéphanie; Aguesse, Audrey; Garfa, Aya; Famchon, Gilles; Torres, Amada; Le May, Cédric; Pichelin, Matthieu; Bigot-Corbel, Edith; Lambert, Gilles; Cariou, Bertrand; Hadjadj, Samy; Krempf, Michel; Bach-Ngohou, Kalyane; Croyal, Mikaël.

J Lipid Res; 61(7): 1128-1139, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32404332

10.

A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.

Evison, Benny J; Palmer, James T; Lambert, Gilles; Treutlein, Herbert; Zeng, Jun; Nativel, Brice; Chemello, Kévin; Zhu, Qing; Wang, Jie; Teng, Yanfen; Tang, Wei; Xu, Yanfeng; Rathi, Anuj Kumar; Kumar, Sanjay; Suchowerska, Alexandra K; Parmar, Jasneet; Dixon, Ian; Kelly, Graham E; Bonnar, James.

Bioorg Med Chem; 28(6): 115344, 2020 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-32051094

11.

Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor): Implications for the Efficacy of Evolocumab.

Thedrez, Aurélie; Blom, Dirk J; Ramin-Mangata, Stéphane; Blanchard, Valentin; Croyal, Mikaël; Chemello, Kévin; Nativel, Brice; Pichelin, Matthieu; Cariou, Bertrand; Bourane, Steeve; Tang, Lihua; Farnier, Michel; Raal, Frederick J; Lambert, Gilles.

Arterioscler Thromb Vasc Biol; 38(3): 592-598, 2018 03.

Artículo en Inglés | MEDLINE | ID: mdl-29284604

12.

Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study.

Blanchard, Valentin; Ramin-Mangata, Stéphane; Billon-Crossouard, Stéphanie; Aguesse, Audrey; Durand, Manon; Chemello, Kevin; Nativel, Brice; Flet, Laurent; Chétiveaux, Maud; Jacobi, David; Bard, Jean-Marie; Ouguerram, Khadija; Lambert, Gilles; Krempf, Michel; Croyal, Mikaël.

J Lipid Res; 59(5): 892-900, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29540575

13.

PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate.

Croyal, Mikaël; Tran, Thi-Thu-Trang; Blanchard, Rose Hélène; Le Bail, Jean-Christophe; Villard, Elise F; Poirier, Bruno; Aguesse, Audrey; Billon-Crossouard, Stéphanie; Ramin-Mangata, Stéphane; Blanchard, Valentin; Nativel, Brice; Chemello, Kévin; Khantalin, Ilya; Thedrez, Aurélie; Janiak, Philip; Krempf, Michel; Boixel, Christophe; Lambert, Gilles; Guillot, Etienne.

Clin Sci (Lond); 132(10): 1075-1083, 2018 05 31.

Artículo en Inglés | MEDLINE | ID: mdl-29724769

14.

Heart to heart with PCSK9.

Chemello, Kevin; Jaafar, Ali K; Lambert, Gilles.

Eur Heart J; 42(32): 3091-3093, 2021 08 21.

Artículo en Inglés | MEDLINE | ID: mdl-34324660

15.

Recent advances in demystifying the metabolism of lipoprotein(a).

Chemello, Kévin; Chan, Dick C; Lambert, Gilles; Watts, Gerald F.

Atherosclerosis; 349: 82-91, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35606080

16.

The size of apolipoprotein (a) is an independent determinant of the reduction in lipoprotein (a) induced by PCSK9 inhibitors.

Blanchard, Valentin; Chemello, Kévin; Hollstein, Tim; Hong-Fong, Clément Chong; Schumann, Friederike; Grenkowitz, Thomas; Nativel, Brice; Coassin, Stefan; Croyal, Mikaël; Kassner, Ursula; Lamina, Claudia; Steinhagen-Thiessen, Elisabeth; Lambert, Gilles.

Cardiovasc Res; 118(9): 2103-2111, 2022 07 20.

Artículo en Inglés | MEDLINE | ID: mdl-34314498

17.

Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk.

Coassin, Stefan; Chemello, Kevin; Khantalin, Ilya; Forer, Lukas; Döttelmayer, Patricia; Schönherr, Sebastian; Grüneis, Rebecca; Chong-Hong-Fong, Clément; Nativel, Brice; Ramin-Mangata, Stéphane; Gallo, Antonio; Roche, Mathias; Muelegger, Beatrix; Gieger, Christian; Peters, Annette; Zschocke, Johannes; Marimoutou, Catherine; Meilhac, Olivier; Lamina, Claudia; Kronenberg, Florian; Blanchard, Valentin; Lambert, Gilles.

Circ Genom Precis Med; 15(2): e003489, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35133173

18.

Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab.

Chemello, Kévin; Beeské, Sandra; Trang Tran, Thi Thu; Blanchard, Valentin; Villard, Elise F; Poirier, Bruno; Le Bail, Jean-Christophe; Dargazanli, Gihad; Ho-Van-Guimbal, Sophie; Boulay, Denis; Bergis, Olivier; Pruniaux, Marie-Pierre; Croyal, Mikaël; Janiak, Philip; Guillot, Etienne; Lambert, Gilles.

JACC Basic Transl Sci; 5(6): 549-557, 2020 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-32613143

19.

PCSK9: from biology to clinical applications.

Blanchard, Valentin; Khantalin, Ilya; Ramin-Mangata, Stéphane; Chémello, Kévin; Nativel, Brice; Lambert, Gilles.

Pathology; 51(2): 177-183, 2019 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-30522786

20.

Lipoprotein(a): More Than Just a Biomarker of Myocardial Fibrosis.

Lambert, Gilles; Chemello, Kévin; Gallo, Antonio.

J Am Coll Cardiol; 82(24): 2292-2295, 2023 12 12.

Artículo en Inglés | MEDLINE | ID: mdl-38057071

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