FeN3S1─OH Single-Atom Sites Anchored on Hollow Porous Carbon for Highly Efficient pH-Universal Oxygen Reduction Reaction.

Regulating the asymmetric active center of a single-atom catalyst to optimize the binding energy is critical but challenging to improve the overall efficiency of the electrocatalysts. Herein, an effective strategy is developed by introducing an axial hydroxyl (OH) group to the Fe─N4 center, simultaneously assisting with the further construction of asymmetric configurations by replacing one N atom with one S atom, forming FeN3S1─OH configuration. This novel structure can optimize the electronic structure and d-band center shift to reduce the reaction energy barrier, thereby promoting oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic activities. The optimal catalyst, FeSA-S/N-C (FeN3S1─OH anchored on hollow porous carbon) displays remarkable ORR performance with a half-wave potential of 0.92, 0.78, and 0.64 V versus RHE in 0.1 m KOH, 0.5 m H2SO4, and 0.1 m PBS, respectively. The rechargeable liquid Zn-air batteries (LZABs) equipped with FeSA-S/N-C display a higher power density of 128.35 mW cm-2, long-term operational stability of over 500 h, and outstanding reversibility. More importantly, the corresponding flexible solid-state ZABs (FSZABs@FeSA-S/N-C) display negligible voltage changes at different bending angles during the charging and discharging processes. This work provides a new perspective for the design and optimization of asymmetric configuration for single-atom catalysts applied to the area of energy conversion and storage.

New 2D Metal-Organic Monoacid Framework (MOmAF): Realization of Extreme Water Repellence.

Metal-organic frameworks (MOFs) are normally moisture-sensitive and unstable in aqueous environments, which has considerably limited their practical applications because water/moisture is ubiquitous in many industrial processes. New materials with superior water stability are, therefore, in great demand and vital to their practical applications. Here, a novel oil/water interfacial assembly strategy is demonstrated for the synthesis of a new class of metal-organic monoacid framework (MOmAF) with exceptional water stability and chemical stability. Superhydrophobic 2D sheets are synthesized at room temperature, while 1D nanotubes are obtained via the self-scrolling of their 2D sheets for the first time. In addition, a simple sequential drop-casting method is developed to coat as-synthesized MOmAF structures onto porous membranes. This can potentially open up new avenues in the design of superhydrophobic self-cleaning MOmAF materials without tedious post-synthetic modifications and usher in a new class of materials meeting industrial needs.

Trance Amount of Ir Decorated NiFe Phosphide In-Situ Grown on Carbon Cloth as Cost-Effective Electrocatalyst for Oxygen Evolution Reaction.

Cost-effective electrocatalysts is a key constituent to establish the balance of cost and catalytic efficiency for oxygen evolution reaction (OER) via water electrolysis in the area of energy conversion and storage. NiFe phosphide decorated with trace amount of iridium (Ir) species in-situ grown on carbon cloth was prepared by a facile wet chemistry approach followed by a phosphorization post-treatment at a relative low temperature. The optimal electrocatalyst, Ir2-NiFePx/CC, exhibits excellent OER activity, with an low overpotential of 190 mV at 10 mA cm-2 for alkaline OER, and a desirable long-term durability over 90 h. The outstanding OER performance stems from the structural evolution via phosphorization process, Ir decoration with more high-valence stated Ir4+ species, and tight connection between individual components of the electrode, which gives rise to the strong activity to the active sites and faster reaction kinetics in the alkaline OER process. Mover, the Ir loading was as low as approximately ~1.7 wt% (0.29 mg cm-2), showing promissing propective in cost-effective OER.

"Fence" Effect Enabling a Metal-Organic Framework-Derived Single-Atom Co-N-C Catalyst for High-Performance Zn-Air Batteries.

It offers bright prospects to develop non-Pt group metal (non-PGM) electrocatalysts in the area of energy storage and conversion. Herein, we reported a simple spatial isolation strategy to synthesize Co-based electrocatalysts, using partially substituted Zn atoms in a ZnCo-ZIF precursor. The "fence" effect that originated from the partially substituted Zn atoms can yield a better isolation of Co atoms, achieving selective loading of Co species on nitrogen-doped porous carbon varying from nanoparticles to single atoms. The low boiling point of Zn enables abundant porous structures to the N-doped carbon substrate after pyrolysis. The best performing single-atom Co catalyst (Co-SAs/N-C) exhibits excellent oxygen reduction reaction activity in alkaline media. As an illustration, the rechargeable liquid Zn-air battery incorporating the Co-SAs/N-C catalyst demonstrates a substantial open circuit voltage of 1.49 V, a high specific capacity of 689.3 mAh g-1, and remarkable cycling stability over 200 h. This study paves the way for the strategic development of non-PGM electrocatalysts in battery applications.

Constructing a Self-Supported Bifunctional Multiphase Heterostructure for Electrocatalytic Overall Water Splitting.

Developing well-performing and stable bifunctional electrocatalysts is of great importance for efficient green hydrogen production through water electrolysis. Herein, a three-dimensional self-supported CoMoS3.13/FeS2/Co3S4 on carbon paper (FeCoMoS/CP) heterostructure with interconnected nanosheets for overall water splitting was fabricated by a facile hydrothermal method followed by vulcanization treatment. The FeCoMoS/CP heterostructure with high structural integrity and more accessible active sites can effectively optimize the electronic structure through component regulation to achieve enhanced catalytic activity. Significantly, the FeCoMoS/CP required overpotentials of 257 mV at 50 mA cm-2 for OER and 280 mV at 20 mA cm-2 for HER. Importantly, the assembled FeCoMoS/CP||FeCoMoS/CP alkaline electrolyzer achieved a superior cell voltage of 1.48 V at 10 mA cm-2 with superb long-term stability, which implies a remarkable electrocatalytic performance of the FeCoMoS/CP heterostructure for overall water splitting. This work provides an applicable route for synthesizing high-performance bifunctional catalysts toward water electrolysis.

Multicomponent Interface and Electronic Structure Engineering in Ir-Doped CoMO4-Co(OH)2 (M = W and Mo) Enable Promoted Oxygen Evolution Reaction.

The core principles of multicomponent interface and electronic structure engineering are essential in designing high-performance catalysts for the oxygen evolution reaction (OER). However, combining these aspects within a catalyst is a significant challenge. In this investigation, a novel approach involving the development of hybrid Ir-doped CoMO4-Co(OH)2 (M = W and Mo) hollow nanoboxes was introduced, enabling remarkably efficient water oxidation electrocatalysis. Constructed from ultrathin nanosheet-assembled hollow nanoboxes, these structures boast a wealth of active centers for intermediate species, which in turn enhance both charge transfer and mass transport capabilities. Moreover, the compelling electronic and synergistic effects arising from the interaction between CoMO4 and Co(OH)2 significantly bolster OER electrocatalysis by facilitating efficient electron transfer. The introduction of Ir atoms serves to strategically adjust the electronic structure, fine-tune its electronic state, and operate as active centers to enhance OER electrocatalysis, thus diminishing the overpotential. This configuration results in Ir-CoWO4-Co(OH)2 and Ir-CoMoO4-Co(OH)2 exhibiting impressively low overpotentials of 252 and 261 mV, respectively, to 10 mA cm-2. Utilized in conjunction with the Pt/C catalyst in a two-electrode system for overall water splitting, a mere 1.53 V cell potential is needed to achieve the desired 10 mA cm-2 current density.

Enhancing the Activity of a Carbon Nitride Photocatalyst by Constructing a Triazine-Heptazine Homojunction.

Establishing homojunctions at the molecular level between different but physicochemically similar phases belonging to the same family of materials is an effective approach to promoting the photocatalytic activity of polymeric carbon nitride (CN) materials. Here, we prepared a CN material with a uniform distribution of homojunctions by combining two synthetic strategies: supramolecular assemblies as the precursor and molten salt as the medium. We designed porous CN rods with triazine-heptazine homojunctions (THCNs) using a melem supramolecular aggregate (Me) and melamine as the precursors and a KCl/LiBr salt mixture as the liquid reaction medium. The triazine/heptazine ratio is controlled by varying the relative amounts of the chosen precursors, and the molten salt treatment enhances the structural order of the interplanar packing units for the THCN skeleton, leading to rapid charge migration. The resulting built-in electric field induced by the triazine-heptazine homojunction enhances photogenerated charge separation; the optimal THCN catalyst exhibits an excellent H2 evolution rate via photocatalytic water splitting, which is ∼24 times as high as that of reference bulk CN, with long-term stability.

3D Hollow Hierarchical Porous Carbon with Fe-N4 -OH Single-Atom Sites for High-Performance Zn-Air Batteries.

The development of innovative and efficient Fe-N-C catalysts is crucial for the widespread application of zinc-air batteries (ZABs), where the inherent oxygen reduction reaction (ORR) activity of Fe single-atom sites needs to be optimized to meet the practical application. Herein, a three-dimensional (3D) hollow hierarchical porous electrocatalyst (ZIF8@FePMPDA-920) rich in asymmetric Fe-N4 -OH moieties as the single atomic sites is reported. The Fe center is in a penta-coordinated geometry with four N atoms and one O atom to form Fe-N4 -OH configuration. Compared to conventional Fe-N4 configuration, this unique structure can weaken the adsorption of intermediates by reducing the electron density of the Fe center for oxygen binding, which decreases the energy barrier of the rate-determining steps (RDS) to accelerate the ORR and oxygen evolution reaction (OER) processes for ZABs. The rechargeable liquid ZABs (LZABs) equipped with ZIF8@FePMPDA-920 display a high power density of 123.11 mW cm-2 and a long cycle life (300 h). The relevant flexible all-solid-state ZABs (FASSZABs) also display outstanding foldability and cyclical stability. This work provides a new perspective for the structural design of single-atom catalysts in the energy conversion and storage areas.

Cascade Performance of Nitroarenes with Alcohols Boosted by a Hollow Flying Saucer-Shaped Ni-Al2O3 Catalyst via a MOF-Templated Strategy Induced by the Kirkendall Effect.

Catalysts with an open hollow structure can enhance the mass transfer capability of the catalyst during the reaction process, thereby further improving the catalytic performance. In this work, uniform and monodisperse flying-squircher-shaped Al-MOFs were synthesized via a solvothermal method. Furthermore, a hollow structure Al2O3-supported metallic Ni catalyst (termed Ni-Al2O3-HFA) was synthesized via the Kirkendall effect for the hydrogenation-alkylation cascade reaction by employing as-synthesized Al-MOFs as a carrier for impregnation of Ni(NO3)2·6H2O through further calcination and reduction. Various characterizations (e.g., XRD, HADDF-STEM, H2-TPR) were conducted to reveal the superior performance of the developed Ni-Al2O3-HFA catalyst compared to Ni/Al2O3-IWI (Al2O3 obtained from calcination of Al-MOFs) in cascade reaction between nitroarenes and alcohols. We hope to use the MOF template method via the Kirkendall effect to prepare hollow structure nanocatalysts, which can provide a guideline for the preparation of other hollow materials.

Etched High-Entropy Prussian Blue Analogues as Trifunctional Catalysts for Water, Ethanol, and Urea Electrooxidation.

The introduction of high-entropy and high specific surface area into Prussian blue analogues (PBAs) has yet to create interest in the field of electrocatalytic small-molecule oxidation reactions. Herein, we synthesize a novel class of high-entropy (HE) PBAs with a high specific surface area via a simple NH3·H2O-etching strategy and systematically investigate the electrocatalytic performance of HE-PBA toward electrocatalytic water, ethanol, and urea oxidation reactions. Importantly, the NH3·H2O-etched HE-PBA (denoted as HE-PBA-e) demonstrated enhanced electrocatalytic performance toward small-molecule oxidation compared to the pristine HE-PBA, reaching 10 mA cm-2 with potentials of 1.56, 1.41, and 1.37 V for the oxygen evolution reaction (OER), ethanol oxidation reaction (EOR), and urea oxidation reaction (UOR), respectively. Deep characterizations suggest that the NH3·H2O etching treatment not only creates rich nanopores to enlarge the surface area and boosts the mass transport and electron transfer but also facilitates the formation of high-valence metal oxides to improve the intrinsic activity. This demonstration of how systematically increasing the high oxidation state of metals will serve as a governing principle for the rational design of more advanced HE-PBAs toward the electrooxidation of small molecules.

Mechanistic Insights into a Co(II)-Coordinated "Free" Metal Site of 2D Zinc-Based MOFs for ß-Alkylation of Secondary Alcohols with Primary Alcohols.

Through in-depth study of the properties and reaction mechanisms of catalysts, it is possible to better optimize catalytic systems and improve reaction efficiency and selectivity. This remains one of the challenges in the field of catalysis. Therefore, the research and design of catalysts play crucial roles in understanding and optimizing catalytic reaction mechanisms. A robust 2D zinc-based MOFs (Zn-HA) supported Co(II) ion catalyst (Zn-HA@Co) has been designed and synthesized via a coordination-assisted strategy for ß-alkylation of secondary alcohols with primary alcohols. The characterization demonstrated that the anchoring of Co(II) on Zn-HA via coordination could efficiently enhance the Co(II) ion dispersity and interaction between Co(II) and Zn-HA MOFs. Importantly, the density functional theory results have provided mechanistic insights into the energy of the HOMO and LUMO of the Zn-HA@Co catalyst as well as the energy change of the entire process after interacting with the reactants and the specific energy changes of each orbital. The synthesized Zn-HA@Co MOFs effectively lower the energy barrier of the catalytic reaction process. We expect that our research and design of catalysts will serve as valuable guideline for understanding and optimizing catalytic reaction mechanisms.

Hierarchical Hollow CoWO4-Co(OH)2 Heterostructured Nanoboxes Enabling Efficient Water Oxidation Electrocatalysis.

Rational design and construction of well-defined hollow heterostructured nanomaterials assembled by ultrathin nanosheets overtakes crucial role in developing high-efficiency oxygen evolution reaction (OER) electrocatalysts. Herein, a reliable metal-organic framework-mediated and cation-exchange strategy to tune the geometric structure and multicomponent heterostructures has been proposed for the fabrication of hollow CoWO4-Co(OH)2 hierarchical nanoboxes assembled by rich ultrathin nanosheets. Benefiting from the hierarchical hollow nanostructure, the CoWO4-Co(OH)2 nanoboxes offer plenty of metal active centers available for reaction intermediates. Moreover, the well-defined nanointerfaces between CoWO4 and Co(OH)2 can function as the bridge for boosting the efficient electron transfer from CoWO4 to Co(OH)2. As a consequence, the optimized CoWO4-Co(OH)2 nanoboxes can exhibit outstanding electrocatalytic performance toward OER by delivering 10 mA cm-2 with a low overpotential of 280 mV and a small Tafel slope of 70.6 mV dec-1 as well as outstanding electrochemical stability. More importantly, this CoWO4-Co(OH)2 heterostructured nanocatalyst can couple with Pt/C to drive overall water splitting to achieve 10 mA cm-2 with a voltage of 1.57 V.

Engineering Heterostructured Pd-Bi2Te3 Doughnut/Pd Hollow Nanospheres for Ethylene Glycol Electrooxidation.

The electrooxidation of ethylene glycol (EG) is of vital significance for the conversion from biomass energy into electrical energy via direct fuel cells. However, the EG oxidation reaction (EGOR) suffers from poor efficiency due to the limitation of high-performance electrocatalysts for cleaving the C-C bonds. Herein, this limitation is successfully addressed by fabricating the doughnut-shaped Pd-Bi2Te3 heterostructured catalyst. Notably, the heterojunction Pd-Bi2Te3 nanocatalyst has been demonstrated to be highly active toward the EGOR with superb activity and durability, in which a mass activity as high as 2420.8 mA mg-1 is achieved in alkaline media, being 1.7 times higher than that of the commercial Pd/C catalyst. Upon combination of experimental results with mechanism studies, it is indicated that the remarkable EGOR performance is attributed to the enlarged active areas that stemmed from the doughnut-like structure, as well as the strong synergistic effect from Pd-Bi2Te3 and Pd. More importantly, the highly electroactive Pd-Bi2Te3 can accelerate charge transfer and boost the oxidation of CO-like intermediates, which are conducive to the enhancement in electrochemical stability.

Successive Anion/Cation Exchange Enables the Fabrication of Hollow CuCo2S4 Nanorods for Advanced Oxygen Evolution Reaction Electrocatalysis.

Hollow CuCo2S4 nanorods (H-CCS-Ns) have been successfully developed via a facile successive anion/cation-exchange method. The outstanding electrocatalytic performance of H-CCS-Ns is mainly attributed to its distinctive hollow structure, which accelerates the electron transfer rate and provides abundant active sites. Moreover, a mechanism study indicates that H-CCS-Ns has highly active octahedral Co3+, and the existence of Co3+ cations optimizes the adsorption of oxygen-involved intermediates, making H-CCS-Ns a promising OER electrocatalyst. Optimized H-CCS-Ns only need an ultralow overpotential of 220 mV to drive a current density of 10 mA·cm-2 and exhibit distinguished cycling stability with a negligible fluctuation for 30 h. More impressively, when H-CCS-Ns are assembled with Pt/C for overall water splitting, a voltage as low as 1.545 V is required at a current density of 10 mA·cm-2, and the catalyst shows outstanding stability for as long as 38 h. This study offers a feasible strategy to design hollow spinel catalysts for efficient OER catalysis.

A facile solvothermal syntheses of NiFe layered double hydroxide-Bi2MoO6 heterostructure/reduced graphene oxide with efficient photodegradation for tetracycline.

A heterojunction of NiFe layered double hydroxide (NiFe LDH)-Bi2MoO6 (BMO) loaded on reduced graphene oxide (RGO) sheets was synthesized via an eco-friendly solvothermal reaction. The structural characterization shows that NiFe LDH-BMO heterojunctions are well-distributed on the surface of silk-like transparent RGO sheets. The modification of BMO by NiFe LDH and RGO greatly enhances the photocatalytic performance of BMO for degradation of tetracycline (TC) under visible light. The photocatalyst prepared with 3 wt% RGO shows the highest activity and cycle stability. TC can be completely removed in 80 min, which is about 8.7 times that pure BMO, and showing excellent reusability even after five cycles. The excellent enhancement of photocatalytic performance of NiFe LDH-BMO/RGO composite is attributed to the unique sheet-on-sheet hierarchical heterostructure combined with RGO sheets, facilitating the visible light absorption and photogenerated charge carriers separation.

Rational design of nano-Fe3O4encapsulated in 3D honeycomb biochar for enhanced lithium storage performance.

Developing green materials applied in lithium-ion batteries is of significant importance for the present-day society. Herein, a feasible strategy to construct Fe3O4nanoparticles (NPs) embedded in three-dimensional (3D) honeycomb biochar derived from pleurotus eryngii was proposed. The obtained material consists of Fe3O4NPs (35-85 nm) encapsulated in 3D honeycomb biochar possesses a high specific capacity of 723 mAh g-1at 1.5 A g-1after 1000 cycles. The effectively enhanced cycling life of Fe3O4@C nanocomposites can be ascribed to the small Fe3O4NPs provide lower degree of cracking and high specific capacity, while the honeycomb biochar function like a cage to inhibit huge volume change of Fe3O4NPs during the charge-discharge process.

Vasodilator-stimulated phosphoprotein (VASP), a novel target of miR-4455, promotes gastric cancer cell proliferation, migration, and invasion, through activating the PI3K/AKT signaling pathway.

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs which play important roles in the carcinogenesis of gastric cancer (GC). Expression profiling of miRNAs in paired gastric cancer and adjacent normal gastric tissues has demonstrated that miR-4455 is down-regulated in gastric cancer tissues, but its functional role in the carcinogenesis of GC had not previously been investigated. AIMS: The purpose of this study was to investigate the functional and biological mechanisms of miR-4455 in the progression of GC, in vitro. METHODS: Expression of miR-4455 was compared in human GC tissue samples and paired adjacent normal tissue samples. The in vitro effects of miR-4455 expression in MGC-803 cells on their proliferation, invasion, and migration were assessed by MTT assays and 5-bromo-2'-deoxyuridine staining, matrigel-invasion analysis and wound healing assays. Bioinformatics analysis (using PicTar, target scan and miRBase target) was used to identify potential targets for miR-4455, and the luciferase reporter assay, qRT-PCR and Western-blotting analyses were used to confirm VASP as the target of miR-4455. In addition, the effects of downregulation of VASP on the activation of PI3K/AKT signaling pathway were measured using Western-blot analysis. RESULTS: The expression of miR-4455 was markedly down-regulated in gastric cancer tissues vs. adjacent normal tissues, and miR-4455 expression inhibited the proliferation, invasion and migration of MGC-803 GC cells in vitro. Luciferase reporter assays revealed that miR-4455 inhibited VASP expression by targeting the 3'-UTR sequence of VASP. Furthermore, silencing of VASP markedly inhibited the activation of the PI3K/AKT signaling pathway. CONCLUSION: Our results suggest that miR-4455 functions as a tumor suppressor in gastric cancer, by targeting VASP leading to activation of the PI3K/AKT signaling pathway and the inhibition of VASP mediated proliferation, migration and invasion of gastric cancer cells.

A glassy carbon electrode modified with nitrogen-doped reduced graphene oxide and melamine for ultra-sensitive voltammetric determination of bisphenol A.

A composite was prepared at room temperature from nitrogen-doped reduced graphene oxide (N-rGO) and melamine via π-interaction. An ultra-sensitive electrochemical sensor for the determination of trace levels of bisphenol A (BPA) was obtained by coating a glassy carbon electrode (GCE) with the composite. The structure and morphology of composite were characterized by FTIR, Raman, XRD, XPS, SEM and TEM. Because of the synergetic effects of N-rGO and melamine, the modified GCE displays considerably enhanced sensitivity to BPA. The voltammetric response, typically measured at a peak of 0.48 V (vs. SCE) is linear in the 0.05 to 20 µM BPA concentration range, and the detection limit is 0.8 nM (at S/N = 3). The sensor is reproducible, stable and selective. It was applied to analyze baby bottles, drinking cups, mineral water bottles and shopping receipts that were spiked with BPA, and the recoveries reached 99.1-101.4%. Graphical abstract Illustration of fabricating the electrochemical sensor for detecting BPA. N-G/M: nitrogen-doped reduced graphene oxide and melamine composite; GCE: glassy carbon electrode.

Improved ciprofloxacin removal by a Fe(VI)-Fe3O4/graphene system under visible light irradiation.

In this paper, Fe3O4/graphene (Fe3O4/GE) nanocomposites were prepared by a co-precipitation method and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and UV-vis diffuse reflectance spectra (UV-vis DRS). The composites were used in combination with Fe(VI) to construct a Fe(VI)-Fe3O4/GE system in order to degrade ciprofloxacin (CIP) in simulated water samples. The photocatalytic properties of Fe(VI)-Fe3O4/GE were evaluated under visible light irradiation. The concentration of CIP in solution was detected by high performance liquid chromatography (HPLC). A series of results showed that Fe(VI), as a good electron capture agent, could significantly improve the treatment performance. Major determining factors during CIP degradation were also investigated, in which solution pH of 9, Fe(VI) to Fe3O4/GE dosage ratio of 1:25 and GE content in the Fe3O4/GE nanocomposites of 10 wt% were found to be the best experimental conditions. The results demonstrated that the Fe(VI)-Fe3O4/GE system could offer an alternative process in water treatment in addition to the current Fe(VI)-UV/TiO2 process.

Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer.

The pathogenesis of colorectal cancer remains poorly understood. Here, we show that coactivator-associated arginine methyltransferase 1 is frequently upregulated in colorectal cancer tissues and promotes cell growth in vitro and in vivo. Using bioinformatics-based prediction and luciferase reporter system, we found that coactivator-associated arginine methyltransferase 1 is post-transcriptionally targeted by microRNA-195-5p in colorectal cancer. Ectopic expression of microRNA-195-5p led to the suppression of the coactivator-associated arginine methyltransferase 1 3'-untranslated regions activity and downregulation of the endogenous coactivator-associated arginine methyltransferase 1 protein in colorectal cancer cells. Expression analysis verified that microRNA-195-5p was markedly downregulated in human colorectal cancer tissues, which was negatively correlated with the elevated levels of coactivator-associated arginine methyltransferase 1 protein. Enhanced levels of microRNA-195-5p in colorectal cancer cells resulted in a sharp reduction of cell proliferative and colony-formative capacities in vitro. Remarkably, restoration of coactivator-associated arginine methyltransferase 1 in microRNA-195-5p-transfected colorectal cancer cells partially abrogated the inhibition of cell proliferation and colony formation mediated through microRNA-195-5p. These data confirm that microRNA-195-5p might function as an anti-tumor microRNA in colorectal cancer exerting critical control over coactivator-associated arginine methyltransferase 1 expression. The newly identified microRNA-195-5p/coactivator-associated arginine methyltransferase 1 axis may act as a novel promising therapeutic target for colorectal cancer treatment.