Pulmonary cryptococcosis: comparison of CT findings in immunocompetent and immunocompromised patients.

BACKGROUND: Computed tomography (CT) findings in patients with pulmonary cryptococcosis have been reported, however, many reports were limited by the small number of patients, and not taken into account the distinction between immunocompetent and immunocompromised patients. PURPOSE: To retrospectively evaluate thoracic CT findings in patients with pulmonary cryptococcosis whose immune status ranged from normal to severely compromised, and determine characteristic imaging features of pulmonary cryptococcosis between patients with different immune status. MATERIAL AND METHODS: CT scan findings of 29 immunocompetent and 43 immunocompromised patients with clinically proven pulmonary cryptococcosis were reviewed retrospectively. Different patterns of CT scan abnormalities between immunocompromised and immunocompetent patients, AIDS and non-AIDS immunocompromised patients were compared by Fisher's exact test. RESULTS: Pulmonary nodules/masses, either solitary or multiple, were the most common CT finding, present in 65 (90.3%) of the 72 patients; associated findings included CT halo sign (n = 24), cavitation (n = 23), and air bronchogram (n = 17). Areas of consolidation (n = 14), areas of GGO (n = 13), linear opacities (n = 11), lymphadenopathy (n = 5), and pleural effusion (n = 8) were uncommon. The parenchymal abnormalities were peripherally located in 47 (65.2%) of the cases. Cavitations within nodules/masses were more frequently present in immunocompromised patients than in immunocompetent patients (P = 0.009), and in AIDS patients than in non-AIDS immunocompromised patients (P = 0.002). Air bronchograms within nodules/masses were more frequent present in immunocompetent patients than in immunocompromised patients (P = 0.005). Nodules/masses with halo sign were less frequent in AIDS patients than those in non-AIDS immunocompromised patients (P = 0.027). CONCLUSION: Pulmonary cryptococcosis should be considered in the differential diagnosis of solitary or multiple pulmonary nodules. Cavitations within nodules/masses were more commonly seen in immunocompromised patients, especially AIDS patients, while air bronchograms were more commonly seen in immunocompetent patients.

Primary Pulmonary Enteric Adenocarcinoma: Rare Imaging Findings.

INTRODUCTION: Pulmonary enteric adenocarcinoma (PEAC) is an extremely rare variant of lung adenocarcinoma characterized by pathological features similar to those of colorectal adenocarcinoma. It is mostly observed on computed tomography (CT) and positron emission tomography (PET)/CT as solitary or multiple nodules/masses in the lung. It tends to grow rapidly and is difficult to distinguish from lung metastatic colorectal cancer. Herein, we have presented a case of PEAC with special imaging findings. CASE PRESENTATION: A chest CT scan of a 72-year-old man with suspected chronic pneumonia revealed a well-defined consolidation in the upper lobe of the left lung. The lesion was slightly enlarged at the 9-month follow-up, and low FDG accumulation was subsequently observed using 18F-fluorodeoxyglucose (18F-FDG) PET/CT scans. The patient was later diagnosed with PEAC through percutaneous lung biopsy. CONCLUSION: Our case has demonstrated specific imaging findings of PEAC.

A rare case of Erdheim-Chester disease with esophageal involvement: unusual imaging findings.

Erdheim-Chester disease (ECD) is an uncommon non-Langerhan cell histiocytosis that affects multiple systems and most commonly involves the bones. A 34-year-old patient with a three-month history of progressive dysphagia, underwent the gastroscopy which revealed esophageal mucosal constriction 34 cm from the incisor and external pressure stenosis. Enhanced computed tomography (CT), magnetic resonance imaging (MRI), and 2-[fluorine-18] fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography (PET)/CT findings confirmed diffuse soft-tissue infiltration filled periesophageal space and excluded lesions involving the bone and other organs within the scanning range. The patient was later diagnosed with esophageal involvement of ECD by thoracotomy surgery and paraesophageal soft tissue biopsy. Progressive dysphagia, a rare clinical manifestation of ECD, has been reported in only two cases. It is the first demonstration of MRI and PET/CT imaging findings of ECD esophageal invasion as far as we known. Through the comparison of multiple images, we have a preliminary recognition of characteristic radiological features of gastrointestinal infiltration in ECD.

An animal experiment about early pulmonary candidiasis in immunosuppressive rabbits: thin-section CT images dynamically observed and proved by histopathological results.

BACKGROUND: Early detection and treatment of pulmonary fungal infection in immunocompromised patients has a profound impact on mortality. However, information available about the thin-section computed tomography (CT) findings of Candida pneumonia has largely been limited to isolated cases seen in reviews of various infections and to other acute lung diseases seen in immunocompromised patients. PURPOSE: To dynamically observe and evaluate CT findings in immunosuppressed animals with histopathologically confirmed pulmonary candidiasis at the acute stage. MATERIAL AND METHODS: Twenty-four New Zealand rabbits were randomly divided into an experimental group (n = 21) and a control group (n = 3). Pulmonary candidiasis was established by C. albicans inoculation via a transtracheal route in immunosuppressed rabbits in the experimental group, and an equivalent amount of normal saline was injected via the same way in the control group. Chest CT scan was performed before and on alternative days after inoculation/injection. Microbiological and pathological results were obtained by autopsy. RESULTS: In the experiment group, pulmonary candidiasis was successfully established in 13 rabbits as confirmed by microbiology and pathology. Areas of air-space consolidation were present in 10 (10/13) rabbits, with lobular distribution in six and lobar or segmental distribution in four, pathologically presenting as bronchopneumonia or hemorrhagic lung infarcts. Areas of ground-glass opacity (GGO) were identified in five (5/13) rabbits, three of which were associated with other abnormalities, presenting as bronchopneumonia or interstitial pneumonitis. Multiple nodules were seen in three (3/13) rabbits. They were clustered around bronchovascular bundles in two rabbits, and subpleural in the remaining one, pathologically presenting as hemorrhagic granulomas. Other less common CT findings included thickening of bronchovascular bundles (n = 3), linear opacity (n = 1), and pneumothorax (n = 1). No abnormality was detected by CT scan and pathological examination in the three rabbits of the control group. CONCLUSION: Peripheral multiple areas of lobular consolidation and/or GGO representing bronchopneumonia were the most common thin-section CT findings of pulmonary candidiasis at the early stage.

Evaluation and Comparison of Quantitative Right Ventricular Strain Assessment by Cardiac Magnetic Resonance in Pulmonary Hypertension Using Feature Tracking and Deformable Registration Algorithms.

RATIONALE AND OBJECTIVE: Deformable registration algorithms (DRA) has been used to detect left ventricular myocardial changes, however, its clinical utility in right ventricular (RV) function has not been evaluated. In this study, we aim to evaluate and compare quantitative RV strain assessment by cardiac magnetic resonance in pulmonary hypertension (PH) using feature tracking (FT) and DRA. MATERIALS AND METHODS: Thirty patients were confirmed to have PH using right heart catheterization, and 16 healthy controls were evaluated with cardiac magnetic resonance. Global and segmental RV strain was measured by DRA and FT methods. Intraclass correlation coefficients (ICCs), coefficient of variation, and Bland-Altman analysis were used to assess and compare the interobserver and intraobserver variability of the DRA and FT methods. RESULTS: DRA was more sensitive than FT in the detection of RV circumferential and septal dysfunction. The global longitudinal strain (GLS) obtained by the two methods was reduced in mild-moderate PH patients (mean pulmonary artery pressure≤45 mm Hg), and the GLS and global circumferential strain (GCS) were reduced in severe PH patients (mean pulmonary artery pressure >45 mm Hg). DRA and FT methods demonstrate similar observer agreement in global strain using ICC (ICC greater than 0.90), but RV strain derived from DRA had lower variability using COV ([8%-14%] for DRA versus [11%-39%] for FT).For segmental longitudinal strain, DRA showed higher ICC and lower COV compared with that of the FT method. Correlations between RVEF and RV global strain parameters were strong (p < 0.01):GLS-DRA, r = -0.696; GLS-FT, r = -0.832; GCS-DRA, r = -0.745; and GCS-FT, r = -0.817. GLS-DRA was weakly correlated with mPAP (r = 0.385, p < 0.05).In multiple linear regression analysis, RVEF and mPAP were independent predictors of GLS-DRA (R2 = 0.57, p < 0.01). CONCLUSIONS: The DRA method is more sensitive and robust for RV myocardial strain measurements than FT method.

Assessing right ventricular function in pulmonary hypertension patients and the correlation with the New York Heart Association (NYHA) classification.

This investigation aimed to compare the pressure-volume loop (PV loop) measurements in three less symptomatic categories (New York Heart Association classes , NYHA I, II, and III) of pulmonary hypertension (PH) patients since NYHA classification system performance is limited by the shortcomings discussed above. Thirty-six patients were enrolled in this study with PV loop measurement acquisition via micro-conductance catheters. Functional classification according to NYHA was determined with comprehensive assessing function and activity. Catheterization and MRI was applied to obtain variables on right ventricle (RV) functions. Correlation test was applied to test the relationship between measured PV loop measurements and NYHA classification. A group of PV loop measurements, including end-systolic pressure (RVESP) RV end-diastolic pressure (RVEDP), and RV arterial elastance (RVEa), are well correlated with three NYHA classes (I, II, and III). Moreover, RVESP and RVEa significantly correlated with two groups of NYHA classes (I and II/III) while RVEDP, RV end-diastolic volume (RVEDV), and RV end-systolic volume (RVESV) significantly moderately correlated with two groups of NYHA classes (I/II and III). This study suggests the promising role of PV loop analysis in assessing functional capacity in progressive but less symptomatic PH patients.

A giant cardiac lipoma associated with ventricular inversion and ventricular aneurysm: ultrasonography and CT imaging findings.

Cardiac lipomas are rare, mostly asymptomatic, and usually found incidentally during noncardiac examinations; however, they also can be symptomatic, depending on their size and location. Here, we report a case of surgically proved pericardial lipoma that was big and for which cardiac structures were substantially altered. The combination of CT imaging and ultrasonography enabled a precise diagnosis in terms of localization, tissue characterization, and complications of the tumor. The origin of the tumor, however, remains undetermined despite a series of postoperative CT scan and ultrasound examinations.