Genetic variations in CYP2A6, CYP2E1, GSTM1, GSTT1 genes and the risk of Nasopharyngeal carcinoma in North African population.

BACKGROUND: Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy associated with both genetic and environmental factors. Polymorphic deletions of the phase I and phase II genes involved in the detoxification of potential carcinogens may be a risk factor for nasopharyngeal carcinoma. In this study, we investigated the relationship between CYP2E1 (rs3813867), CYP2A6, GSTM1(rs1183423000) and GSTT1(rs1601993659) gene variations and NPC risk in North African countries with the highest incidence of NPC (Morocco, Algeria and Tunisia). and the evaluation of the potential use of these variants as potential biomarkers for NPC management. METHODS: A total of 600 NPC cases and 545 controls frequency-matched on ethnicity, sex, age and childhood household type, were recruited from three North African countries (Morocco, Algeria and Tunisia) and analysed. Genotyping of CYP2A6 and CYP2E1(rs3813867) was performed by polymerase chain reaction restriction (PCR)-fragment length polymorphism (RFLP) analysis and the GSTM1 (rs1183423000) and GSTT1(rs1601993659) genetic variations were evaluated using the PCR technique. RESULTS: The genotype distributions of CYP2E1(rs3813867), CYP2A6, GSTM1(rs1183423000) and GSTT1(rs1601993659) genotypes did not differ significantly among NPC cases and controls (p > 0.05). Furthermore, our data did not reveal any association with smoking and the studied variants, even when the samples were stratified by the duration period of smoking. CONCLUSION: In this large studied North African population, our findings suggest that the functional CYP2E1, CYP2A6, GSTM1 and GSTT1 variations did not influence NPC susceptibility.

[A social program for the control of zoonotic cutaneous leishmaniasis in M'Sila, Algeria]. / Un programme social pour la lutte physique contre la leishmaniose cutanée zoonotique dans la wilaya de M'Sila en Algérie.

Zoonotic cutaneous leishmaniasis due to Leishmania major is a serious public health problem in Algeria. On average, 10,000 new cases are reported every year among the 15 million people at risk of infection. With an annual incidence of 561.8 per 100,000 inhabitants, M'Sila has seen the worst outbreak of the disease in Algeria since the historic outbreak in Biskra. The main reservoir of the disease is Psammomys obesus, a gerbil that feeds exclusively on Chenopodiaceae, a salt-tolerant plant under which it makes its burrow. Removing these plants around houses within a radius of 300 meters is one of the most effective control measures. As part of a social program of public works, a pilot project aimed at controlling the disease was undertaken in 2003 in the five worst affected cities in M'Sila. 396 unemployed young people were recruited to remove the plants before the transmission season. Over 3,600 hectares were treated. The number of cases decreased from 1,391 in 2003 to 965 in 2004 (31% reduction). These measures need to be implemented in all endemic areas of the country to better assess their effectiveness in preventing the disease.

[The tobacco problem in French-speaking Africa and regional perspectives of the French-speaking African tobacco observatory]. / Problématique du tabac en Afrique francophone et perspectives régionales de l'OTAF.

The tobacco problem is one which is both global and political. The epidemic and the growing smoking crisis in Africa is a menace to the health of our continent, with significant socio-economic repercussions to follow in the coming years. Approximately 1.1 billion people around the world smoke, and between now and the year 2025, this number will most likely increase to 1.6 billion. By 2030, 10 million tobacco-related deaths will have occurred, and for the most part those deaths will be concentrated in developing countries. The tobacco industry clearly lies at the heart of the development of the tobacco pandemic in the 20th century. Specifically, cigarettes have made tobacco a massively consumed product, constantly expanding and opening up new markets; the day before yesterday it was men, yesterday it was women and youth, and today it is the developing world. The strategy is identical: increase sales, and do goat a price which puts a heavy burden on the population's health. The industries turn themselves towards developing countries, and namely Africa, in order to compensate for their losses in the markets of the Northern Hemisphere at a time when the demand in these countries is decreasing. The industry's cynical strategy targets Africa as its strongest potential market for development, counting on an estimated increase in consumption of 16% over the next decade, according to WHO's recent World Tobacco Atlas. The illegal importation of cigarettes is a practice which is growing more and more within African countries, with a well-structured African network for smuggling. Smuggled cigarettes are even more toxic with very elevated levels of nicotine and tar. Sponsorship as well as direct and indirect advertising are rapidly developing in all kinds of formats, with a proliferation of aggressive advertising messages targeting African populations with cynicism, manipulation, the complicity of smuggling in broad daylight, and disrespect for the law, while exploiting all of the themes which promote tobacco use to the target audiences (youth, women, the poorest groups). Everyday the tobacco industry recruits new African smokers to replace those who die. The future of the industry is represented by about 8 out of 10 people who began smoking before the age of 18 years old. It was imperative to establish a Tobacco Observatory in Francophone Africa (OTAF) in order to resituate the African tobacco situation, contribute to the development of the French-speaking nations in Africa, and to make known and increase awareness of its needs, its initiatives, and its actions across the world, and finally to effectively fight against tobacco and the industry's practices. One year after OTAF was established in Bamako thanks to the consolidated efforts of all its members and support of the French League against Cancer and the International Union against Cancer, OTAF OTAF is an independent entity whose mission is to gather, analyse and disseminate information on all aspects of tobacco with the objective of soliciting and supporting public health activities and interventions. It is a reference centre for Francophone Africa and a technical advisory group for the public authorities on tobacco issues. OTAF's work is counted upon to inform the public authorities on the most effective measures to use in the fight against tobacco. OTAF's duty is to promote activities which protect the health of young people and non-smokers, and communicate on the harmful effects of tobacco and the tobacco industry's practices. The goal is to organise a fight against tobacco based on solid, scientific data of the highest level of quality. OTAF is the only Francophone African surveillance organisation for monitoring the tobacco epidemic, and the practices, schemes and methods of the tobacco industry which are known to be dishonest Today, OTAF is a unique reference centre as far as the fight against tobacco is concerned in Francophone Africa. It is a partner in a number of projects with the French League against Cancer, the International Union against Cancer, and the International Union for Health Promotion and Education, among others. The success of OTAF has been crowned by a trophee having been awarded by WHO and an honorary degree signed by WHO's Director General.