Delayed Auditory Evoked Responses in Autism Spectrum Disorder across the Life Span.

The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of the neural correlates of auditory processing through development from children into adults are very limited. Magnetoencephalography was used to record signals arising from the left and right superior temporal gyrus during auditory presentation of tones to children/adolescents and adults with ASD as well as typically developing (TD) controls. One hundred and thirty-two participants (aged 6-42 years) were included into the final analyses (children/adolescents: TD, n = 36, 9.21 ± 1.6 years; ASD, n = 58, 10.07 ± 2.38 years; adults: TD, n = 19, 26.97 ± 1.29 years; ASD, n = 19, 23.80 ± 6.26 years). There were main effects of group on M50 and M100 latency (p < 0.001) over hemisphere and frequency. Delayed M50 and M100 latencies were found in participants with ASD compared to the TD group, and earlier M50 and M100 latencies were associated with increased age. Furthermore, there was a statistically significant association between language ability and both M50 and M100 latencies. Importantly, differences in M50 and M100 latencies between TD and ASD cohorts, often reported in children, persisted into adulthood, with no evidence supporting latency convergence.

Resuscitation and Evaluation With Intraosseous Access: A Review of the Literature in Trauma and Non-Trauma Patients.

According to trauma resuscitation guidelines, intraosseous (IO) access is appropriate when failure to gain intravenous (IV) access is present in trauma, burn, shock, or resuscitation settings for adults or when two failed attempts have been made in the resuscitation of a pediatric patient. However, their effectiveness and use have been debated due to concerns on flow rates, extravasation, compartment syndrome, and osteomyelitis. The objective of this review is to examine the current literature regarding intraosseous access in trauma resuscitation, focusing on interventions and complication rates.

TranZap: A Transgender Resource for Identifying Gender-Affirming Providers.

INTRODUCTION: Many transgender individuals seeking healthcare have had at least one negative experience related to being transgender. As a result, transgender patients may forego seeking healthcare treatment atall, leading to adverse long-term health outcomes. With barriers to care and oftentimes suboptimal care provided to transgender individuals, TranZap, in collaboration with the PROUD Gender Center of NJ, was commenced. OBJECTIVES: To provide a review on the current transgender resources to finding healthcare, and the impetus behind creating a transgender health app to streamline this process. The vision of this app, TranZap, is to empower transgender individuals who are seeking healthcare such that they are better educated and knowledgeable regarding available healthcare providers. METHODS: With no data available from usual sources, such as Google Scholar, social media, as well as input from the transgender community through social media and word of mouth was utilized to identify the current resources for transgender patients seeking healthcare. This online search was done to identify any type of transgender focused healthcare databases that were community driven. RESULTS: Four resources were identified: TransBucket, TransAtlas, TransHealthCare, and Erin's Informed Consent hormone replacement therapy map of the US. Noting that there are limited resources, an app that is community driven and provides information on all types of healthcare providers, not exclusively surgeons or endocrinologists, was developed. CONCLUSION: Seeking gender-affirming healthcare providers is a strenuous task filled with uncertainty and few reliable resources. Resources that provide the input of transgender individuals on their experiences with healthcare providers is one step in addressing this issue. Resources, such as TranZap, must be developed to close the gaps in access to healthcare by providing a platform for transgender patients to share experiences about healthcare providers in the hopes that those using the app will be able to find a welcoming gender-affirming provider. Chiang T, Bachmann GA. The TranZap: A Transgender Resource for Identifying Gender-Affirming Providers. Sex Med Rev 2022;10:632-635.

TranZap: A Transgender Resource for Identifying Gender-Affirming Providers.

INTRODUCTION: Many transgender individuals seeking healthcare have had at least one negative experience related to being transgender. As a result, transgender patients may forego seeking healthcare treatment atall, leading to adverse long-term health outcomes. With barriers to care and oftentimes suboptimal care provided to transgender individuals, TranZap, in collaboration with the PROUD Gender Center of NJ, was commenced. OBJECTIVES: To provide a review on the current transgender resources to finding healthcare, and the impetus behind creating a transgender health app to streamline this process. The vision of this app, TranZap, is to empower transgender individuals who are seeking healthcare such that they are better educated and knowledgeable regarding available healthcare providers. METHODS: With no data available from usual sources, such as Google Scholar, social media, as well as input from the transgender community through social media and word of mouth was utilized to identify the current resources for transgender patients seeking healthcare. This online search was done to identify any type of transgender focused healthcare databases that were community driven. RESULTS: Four resources were identified: TransBucket, TransAtlas, TransHealthCare, and Erin's Informed Consent hormone replacement therapy map of the US. Noting that there are limited resources, an app that is community driven and provides information on all types of healthcare providers, not exclusively surgeons or endocrinologists, was developed. CONCLUSION: Seeking gender-affirming healthcare providers is a strenuous task filled with uncertainty and few reliable resources. Resources that provide the input of transgender individuals on their experiences with healthcare providers is one step in addressing this issue. Resources, such as TranZap, must be developed to close the gaps in access to healthcare by providing a platform for transgender patients to share experiences about healthcare providers in the hopes that those using the app will be able to find a welcoming gender-affirming provider.

Maturational trajectory of fusiform gyrus neural activity when viewing faces: From 4 months to 4 years old.

Infant and young child electrophysiology studies have provided information regarding the maturation of face-encoding neural processes. A limitation of previous research is that very few studies have examined face-encoding processes in children 12-48 months of age, a developmental period characterized by rapid changes in the ability to encode facial information. The present study sought to fill this gap in the literature via a longitudinal study examining the maturation of a primary node in the face-encoding network-the left and right fusiform gyrus (FFG). Whole-brain magnetoencephalography (MEG) data were obtained from 25 infants with typical development at 4-12 months, and with follow-up MEG exams every ∼12 months until 3-4 years old. Children were presented with color images of Face stimuli and visual noise images (matched on spatial frequency, color distribution, and outer contour) that served as Non-Face stimuli. Using distributed source modeling, left and right face-sensitive FFG evoked waveforms were obtained from each child at each visit, with face-sensitive activity identified via examining the difference between the Non-Face and Face FFG timecourses. Before 24 months of age (Visits 1 and 2) the face-sensitive FFG M290 response was the dominant response, observed in the left and right FFG ∼250-450 ms post-stimulus. By 3-4 years old (Visit 4), the left and right face-sensitive FFG response occurred at a latency consistent with a face-sensitive M170 response ∼100-250 ms post-stimulus. Face-sensitive left and right FFG peak latencies decreased as a function of age (with age explaining greater than 70% of the variance in face-sensitive FFG latency), and with an adult-like FFG latency observed at 3-4 years old. Study findings thus showed face-sensitive FFG maturational changes across the first 4 years of life. Whereas a face-sensitive M290 response was observed under 2 years of age, by 3-4 years old, an adult-like face-sensitive M170 response was observed bilaterally. Future studies evaluating the maturation of face-sensitive FFG activity in infants at risk for neurodevelopmental disorders are of interest, with the present findings suggesting age-specific face-sensitive neural markers of a priori interest.

Maturation of hemispheric specialization for face encoding during infancy and toddlerhood.

Little is known about the neural processes associated with attending to social stimuli during infancy and toddlerhood. Using infant magnetoencephalography (MEG), fusiform gyrus (FFG) activity while processing Face and Non-Face stimuli was examined in 46 typically developing infants 3 to 24 months old (28 males). Several findings indicated FFG maturation throughout the first two years of life. First, right FFG responses to Face stimuli decreased as a function of age. Second, hemispheric specialization to the face stimuli developed somewhat slowly, with earlier right than left FFG peak activity most evident after 1 year of age. Right FFG activity to Face stimuli was of clinical interest, with an earlier right FFG response associated with better performance on tests assessing social and cognitive ability. Building on the above, clinical studies examining maturational change in FFG activity (e.g., lateralization and speed) in infants at-risk for childhood disorders associated with social deficits are of interest to identify atypical FFG maturation before a formal diagnosis is possible.