P29-A135†Impact of COVID-19 on corneal donation and transplantation in Hong Kong.

PURPOSE: With many health and policy issues arising from COVID-19, the Hospital Authority Eye Bank of Hong Kong encountered challenges related to ocular donor suitability and availability. This review aims to analyse the impact of a global pandemic on corneal donation and transplantation in 2020 and 2021, compared to the pre-COVID period in 2019. METHODS: This cohort study evaluated data collected from the Hospital Authority Eye Bank from January 2019 to December 2021. The number of corneas harvested, including voluntary donations initiated by the deceased's relatives and approached cases by Eye Donation Coordinators, tissue distributed, transplanted and disposed, the reason for disposal as well as the usage of the transplanted corneas in 2020 and 2021 were compared to the pre-COVID period of 2019. RESULTS: The number of corneas harvested dropped by 17.6% in 2020 compared to the pre-COVID period of 2019, and rose almost back to baseline in 2021. However, despite having near-normal number of harvested corneas in 2021, the number of corneal transplants using fresh corneas were still reduced by 30% in 2020 and 27% 2021. The observation can be explained by the seven-fold increment in disposal due to suboptimal quality from a cancer donor in 2021. The proportion of corneas used for optical, therapeutic and tectonic purposes remained stable throughout the three years. CONCLUSION: COVID-19 yielded brief periods of service interruption and reduced number of eligible donors, leading to a noticeable rise in solicitation from cancer donors in 2021. The pandemic resulted in a longer corneal transplant waiting time. Nevertheless, The proportion of different corneal transplantation remained stable, with even the development in new techniques such as Descemet's Membrane Endothelial Keratoplasty and enhancement in services such as provision of ultra-fresh Keratolimbal allografts despite the limitations in the COVID-19 era.

The Association of Delayed Corneal Surface and Visual Recovery After Corneal Transplantation With Longer Donor Storage Time-A Prospective Analysis.

PURPOSE: This study aimed to assess the influence of donor corneal storage time on endothelial cell count (ECC), corneal epithelial recovery, and visual rehabilitation after corneal transplantation in the first postoperative year. DESIGN: A collaborative prospective study involving a local eye bank and a tertiary ophthalmic unit was conducted. METHODS: Donor cornea buttons were stored in Optisol-GS (Chiron Ophthalmics Inc, Irvine, Calif) storage media for a maximum of 14 days before transplantation. Before corneal distribution, the eye bank collected information on death-to-harvesting time, death-to-surgery time, donor central corneal thickness, and donor ECC at various time points. Subjects who underwent penetrating keratoplasty and endothelial keratoplasty were recruited and monitored for 1 year. Postoperative epithelial healing, visual acuity, ECC, and hospital stay were evaluated. RESULTS: Thirty-one eyes of 31 patients completed the study. There was a significant positive correlation between donor storage time and epithelial healing (Spearman ρ = 0.39, P = 0.031). Faster epithelial healing was significantly correlated with posttransplantation visual improvements at months 1, 3, and 6 and shorter hospital stay (Spearman ρ = 0.74, P < 0.001). Mean ECC loss was 23.8% at 12 months posttransplantation. There was no significant correlation between storage time and ECC loss preoperatively and posttransplantation. CONCLUSIONS: The duration of graft storage in Optisol-GS storage media up to 14 days had no significant effects on long-term visual acuity and ECC postoperatively. Shorter storage time had significant correlation with earlier epithelial healing and faster visual rehabilitation.