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1.
Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes.
Gene Ther;
30(1-2): 132-141, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35637286
2.
Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes.
J Pharmacol Exp Ther;
385(2): 135-145, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36828631
3.
A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice.
Pharm Res;
39(2): 251-261, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-35146590
4.
Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central nervous system.
J Pharmacokinet Pharmacodyn;
49(3): 337-362, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35092540
5.
Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes.
Int J Mol Sci;
23(15)2022 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955647
6.
Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice.
Drug Metab Dispos;
46(11): 1514-1518, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30115645
7.
Investigation of Antibody Pharmacokinetics in the Brain Following Intra-CNS Administration and Development of PBPK Model to Characterize the Data.
AAPS J;
26(2): 29, 2024 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38443635
8.
Whole-Body Disposition and Physiologically Based Pharmacokinetic Modeling of Adeno-Associated Viruses and the Transgene Product.
J Pharm Sci;
113(1): 141-157, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37805073
9.
Pharmacokinetics of AAV9 Mediated Trastuzumab Expression in Rat Brain Following Systemic and Local Administration.
J Pharm Sci;
113(1): 131-140, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37659717
10.
Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development.
Curr Neuropharmacol;
21(3): 599-620, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-35794768
11.
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview.
J Cereb Blood Flow Metab;
41(8): 1797-1820, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33444097
12.
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models.
Adv Drug Deliv Rev;
170: 214-237, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33486008
13.
Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier.
Neurosci Lett;
751: 135829, 2021 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33727125
14.
In vitro modeling of the neurovascular unit: advances in the field.
Fluids Barriers CNS;
17(1): 22, 2020 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32178700
15.
LC-MS/MS-based in vitro and in vivo investigation of blood-brain barrier integrity by simultaneous quantitation of mannitol and sucrose.
Fluids Barriers CNS;
17(1): 61, 2020 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33054801
16.
Simultaneous UPLC-MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain vascular space.
J Chromatogr B Analyt Technol Biomed Life Sci;
1073: 19-26, 2018 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29232607
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