Detalles de la búsqueda
1.
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group.
Drug Metab Dispos;
2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38697852
2.
Evaluation of the Selectivity of Several Organic Anion Transporting Polypeptide 1B Biomarkers Using Relative Activity Factor Method.
Drug Metab Dispos;
51(9): 1089-1104, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37137718
3.
Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome.
Mol Pharm;
20(7): 3505-3518, 2023 07 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37283406
4.
Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays.
Drug Metab Dispos;
50(7): 909-922, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35489778
5.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos;
49(2): 159-168, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051248
6.
Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs.
BMC Vet Res;
16(1): 234, 2020 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32641048
7.
Mechanism of deoxynivalenol-induced neurotoxicity in weaned piglets is linked to lipid peroxidation, dampened neurotransmitter levels, and interference with calcium signaling.
Ecotoxicol Environ Saf;
194: 110382, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-32146195
8.
Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers.
Antimicrob Agents Chemother;
63(4)2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30745392
9.
Role of transporters in the disposition of a novel ß-lactamase inhibitor: relebactam (MK-7655).
J Antimicrob Chemother;
74(7): 1894-1903, 2019 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891606
10.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos;
47(4): 350-357, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30622164
11.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos;
46(2): 189-196, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29138286
12.
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Drug Metab Dispos;
46(7): 943-952, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695616
13.
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Mol Pharmacol;
89(5): 492-504, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26893303
14.
The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?
Drug Metab Dispos;
44(9): 1498-509, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26825641
15.
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.
Drug Metab Dispos;
44(11): 1752-1758, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27543206
16.
Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.
Drug Metab Dispos;
43(3): 367-74, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25534768
17.
Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab Dispos;
43(6): 851-63, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813937
18.
Raltegravir has a low propensity to cause clinical drug interactions through inhibition of major drug transporters: an in vitro evaluation.
Antimicrob Agents Chemother;
58(3): 1294-301, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24295974
19.
Understanding the transport properties of metabolites: case studies and considerations for drug development.
Drug Metab Dispos;
42(4): 650-64, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24346835
20.
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
Drug Metab Dispos;
42(8): 1301-13, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24855184