1.
Bioorg Med Chem Lett
; 13(3): 489-93, 2003 Feb 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12565957
RESUMEN
The echinocandin class of cyclic lipopeptides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.