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1.

The genetics of non-monogenic IBD.

Jans, Deborah; Cleynen, Isabelle.

Hum Genet; 142(5): 669-682, 2023 May.

Artículo en Inglés | MEDLINE | ID: mdl-36720734

2.

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

Huang, Hailiang; Fang, Ming; Jostins, Luke; Umicevic Mirkov, Masa; Boucher, Gabrielle; Anderson, Carl A; Andersen, Vibeke; Cleynen, Isabelle; Cortes, Adrian; Crins, François; D'Amato, Mauro; Deffontaine, Valérie; Dmitrieva, Julia; Docampo, Elisa; Elansary, Mahmoud; Farh, Kyle Kai-How; Franke, Andre; Gori, Ann-Stephan; Goyette, Philippe; Halfvarson, Jonas; Haritunians, Talin; Knight, Jo; Lawrance, Ian C; Lees, Charlie W; Louis, Edouard; Mariman, Rob; Meuwissen, Theo; Mni, Myriam; Momozawa, Yukihide; Parkes, Miles; Spain, Sarah L; Théâtre, Emilie; Trynka, Gosia; Satsangi, Jack; van Sommeren, Suzanne; Vermeire, Severine; Xavier, Ramnik J; Weersma, Rinse K; Duerr, Richard H; Mathew, Christopher G; Rioux, John D; McGovern, Dermot P B; Cho, Judy H; Georges, Michel; Daly, Mark J; Barrett, Jeffrey C.

Nature; 547(7662): 173-178, 2017 07 13.

Artículo en Inglés | MEDLINE | ID: mdl-28658209

3.

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.

Cleynen, Isabelle; Engchuan, Worrawat; Hestand, Matthew S; Heung, Tracy; Holleman, Aaron M; Johnston, H Richard; Monfeuga, Thomas; McDonald-McGinn, Donna M; Gur, Raquel E; Morrow, Bernice E; Swillen, Ann; Vorstman, Jacob A S; Bearden, Carrie E; Chow, Eva W C; van den Bree, Marianne; Emanuel, Beverly S; Vermeesch, Joris R; Warren, Stephen T; Owen, Michael J; Chopra, Pankaj; Cutler, David J; Duncan, Richard; Kotlar, Alex V; Mulle, Jennifer G; Voss, Anna J; Zwick, Michael E; Diacou, Alexander; Golden, Aaron; Guo, Tingwei; Lin, Jhih-Rong; Wang, Tao; Zhang, Zhengdong; Zhao, Yingjie; Marshall, Christian; Merico, Daniele; Jin, Andrea; Lilley, Brenna; Salmons, Harold I; Tran, Oanh; Holmans, Peter; Pardinas, Antonio; Walters, James T R; Demaerel, Wolfram; Boot, Erik; Butcher, Nancy J; Costain, Gregory A; Lowther, Chelsea; Evers, Rens; van Amelsvoort, Therese A M J; van Duin, Esther.

Mol Psychiatry; 26(8): 4496-4510, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-32015465

4.

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.

Lee, Ho-Su; Lobbestael, Evy; Vermeire, Séverine; Sabino, João; Cleynen, Isabelle.

Gut; 70(2): 408-417, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33067333

5.

Prostaglandin E₂ receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation.

Na, Yi Rang; Jung, Daun; Stakenborg, Michelle; Jang, Hyeri; Gu, Gyo Jeong; Jeong, Mi Reu; Suh, Soo Youn; Kim, Hak Jae; Kwon, Yoon Hey; Sung, Tae Sik; Ryoo, Seung Bum; Park, Kyu Joo; Im, Jong Pil; Park, Ji Yong; Lee, Yun Sang; Han, Heonjong; Park, Boyoun; Lee, Sungwook; Kim, Daesik; Lee, Ho Su; Cleynen, Isabelle; Matteoli, Gianluca; Seok, Seung Hyeok.

Gut; 70(12): 2249-2260, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-33558271

6.

Effect of vedolizumab (anti-α4ß7-integrin) therapy on histological healing and mucosal gene expression in patients with UC.

Arijs, Ingrid; De Hertogh, Gert; Lemmens, Bart; Van Lommel, Leentje; de Bruyn, Magali; Vanhove, Wiebe; Cleynen, Isabelle; Machiels, Kathleen; Ferrante, Marc; Schuit, Frans; Van Assche, Gert; Rutgeerts, Paul; Vermeire, Severine.

Gut; 67(1): 43-52, 2018 01.

Artículo en Inglés | MEDLINE | ID: mdl-27802155

7.

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Jostins, Luke; Ripke, Stephan; Weersma, Rinse K; Duerr, Richard H; McGovern, Dermot P; Hui, Ken Y; Lee, James C; Schumm, L Philip; Sharma, Yashoda; Anderson, Carl A; Essers, Jonah; Mitrovic, Mitja; Ning, Kaida; Cleynen, Isabelle; Theatre, Emilie; Spain, Sarah L; Raychaudhuri, Soumya; Goyette, Philippe; Wei, Zhi; Abraham, Clara; Achkar, Jean-Paul; Ahmad, Tariq; Amininejad, Leila; Ananthakrishnan, Ashwin N; Andersen, Vibeke; Andrews, Jane M; Baidoo, Leonard; Balschun, Tobias; Bampton, Peter A; Bitton, Alain; Boucher, Gabrielle; Brand, Stephan; Büning, Carsten; Cohain, Ariella; Cichon, Sven; D'Amato, Mauro; De Jong, Dirk; Devaney, Kathy L; Dubinsky, Marla; Edwards, Cathryn; Ellinghaus, David; Ferguson, Lynnette R; Franchimont, Denis; Fransen, Karin; Gearry, Richard; Georges, Michel; Gieger, Christian; Glas, Jürgen; Haritunians, Talin; Hart, Ailsa.

Nature; 491(7422): 119-24, 2012 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-23128233

8.

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.

Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke; Schumm, L Philip; Zeissig, Sebastian; Ahmad, Tariq; Andersen, Vibeke; Andrews, Jane M; Annese, Vito; Brand, Stephan; Brant, Steven R; Cho, Judy H; Daly, Mark J; Dubinsky, Marla; Duerr, Richard H; Ferguson, Lynnette R; Franke, Andre; Gearry, Richard B; Goyette, Philippe; Hakonarson, Hakon; Halfvarson, Jonas; Hov, Johannes R; Huang, Hailang; Kennedy, Nicholas A; Kupcinskas, Limas; Lawrance, Ian C; Lee, James C; Satsangi, Jack; Schreiber, Stephan; Théâtre, Emilie; van der Meulen-de Jong, Andrea E; Weersma, Rinse K; Wilson, David C; Parkes, Miles; Vermeire, Severine; Rioux, John D; Mansfield, John; Silverberg, Mark S; Radford-Smith, Graham; McGovern, Dermot P B; Barrett, Jeffrey C; Lees, Charlie W.

Lancet; 387(10014): 156-67, 2016 Jan 09.

Artículo en Inglés | MEDLINE | ID: mdl-26490195

9.

Evolution of cytokines and inflammatory biomarkers during infliximab induction therapy and the impact of inflammatory burden on primary response in patients with Crohn's disease.

Billiet, Thomas; Cleynen, Isabelle; Ballet, Vera; Claes, Karolien; Princen, Fred; Singh, Sharat; Ferrante, Marc; Van Assche, Gert; Gils, Ann; Vermeire, Severine.

Scand J Gastroenterol; 52(10): 1086-1092, 2017 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-28622097

10.

Characteristics of Skin Lesions Associated With Anti-Tumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease: A Cohort Study.

Cleynen, Isabelle; Van Moerkercke, Wouter; Billiet, Thomas; Vandecandelaere, Pieter; Vande Casteele, Niels; Breynaert, Christine; Ballet, Vera; Ferrante, Marc; Noman, Maja; Assche, Gert Van; Rutgeerts, Paul; van den Oord, Joost J; Gils, Ann; Segaert, Siegfried; Vermeire, Séverine.

Ann Intern Med; 164(1): 10-22, 2016 Jan 05.

Artículo en Inglés | MEDLINE | ID: mdl-26641955

11.

A Genetic Variation in the Neonatal Fc-Receptor Affects Anti-TNF Drug Concentrations in Inflammatory Bowel Disease.

Billiet, Thomas; Dreesen, Erwin; Cleynen, Isabelle; Wollants, Willem-Jan; Ferrante, Marc; Van Assche, Gert; Gils, Ann; Vermeire, Severine.

Am J Gastroenterol; 111(10): 1438-1445, 2016 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-27481307

12.

Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn's disease.

Drobne, David; Bossuyt, Peter; Breynaert, Christine; Cattaert, Tom; Vande Casteele, Niels; Compernolle, Griet; Jürgens, Matthias; Ferrante, Marc; Ballet, Vera; Wollants, Willem-Jan; Cleynen, Isabelle; Van Steen, Kristel; Gils, Ann; Rutgeerts, Paul; Vermeire, Severine; Van Assche, Gert.

Clin Gastroenterol Hepatol; 13(3): 514-521.e4, 2015 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-25066841

13.

The genetic architecture of inflammatory bowel disease: past, present and future.

Cleynen, Isabelle; Vermeire, Séverine.

Curr Opin Gastroenterol; 31(6): 456-63, 2015 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-26444824

14.

TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn's disease patients?

Verstockt, Bram; Verstockt, Sare; Blevi, Helene; Cleynen, Isabelle; de Bruyn, Magali; Van Assche, Gert; Vermeire, Séverine; Ferrante, Marc.

Gut; 68(8): 1531-1533, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-30007919

15.

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.

Wouters, Mira M; Lambrechts, Diether; Knapp, Michael; Cleynen, Isabelle; Whorwell, Peter; Agréus, Lars; Dlugosz, Aldona; Schmidt, Peter Thelin; Halfvarson, Jonas; Simrén, Magnus; Ohlsson, Bodil; Karling, Pontus; Van Wanrooy, Sander; Mondelaers, Stéphanie; Vermeire, Severine; Lindberg, Greger; Spiller, Robin; Dukes, George; D'Amato, Mauro; Boeckxstaens, Guy.

Gut; 63(7): 1103-11, 2014 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-24041540

16.

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia.

Wouters, Mira M; Lambrechts, Diether; Becker, Jessica; Cleynen, Isabelle; Tack, Jan; Vigo, Ana G; Ruiz de León, Antonio; Urcelay, Elena; Pérez de la Serna, Julio; Rohof, Wout; Annese, Vito; Latiano, Anna; Palmieri, Orazio; Mattheisen, Manuel; Mueller, Michaela; Lang, Hauke; Fumagalli, Uberto; Laghi, Luigi; Zaninotto, Giovanni; Cuomo, Rosario; Sarnelli, Giovanni; Nöthen, Markus M; Vermeire, Séverine; Knapp, Michael; Gockel, Ines; Schumacher, Johannes; Boeckxstaens, Guy E.

Gut; 63(9): 1401-9, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-24259423

17.

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease.

Cleynen, Isabelle; Vazeille, Emilie; Artieda, Marta; Verspaget, Hein W; Szczypiorska, Magdalena; Bringer, Marie-Agnès; Lakatos, Peter L; Seibold, Frank; Parnell, Kirstie; Weersma, Rinse K; Mahachie John, Jestinah M; Morgan-Walsh, Rebecca; Staelens, Dominiek; Arijs, Ingrid; De Hertogh, Gert; Müller, Stefan; Tordai, Atilla; Hommes, Daniel W; Ahmad, Tariq; Wijmenga, Cisca; Pender, Sylvia; Rutgeerts, Paul; Van Steen, Kristel; Lottaz, Daniel; Vermeire, Severine; Darfeuille-Michaud, Arlette.

Gut; 63(8): 1265-74, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24092863

18.

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.

Cleynen, Isabelle; González, Juan R; Figueroa, Carolina; Franke, Andre; McGovern, Dermot; Bortlík, Martin; Crusius, Bart J A; Vecchi, Maurizio; Artieda, Marta; Szczypiorska, Magdalena; Bethge, Johannes; Arteta, David; Ayala, Edgar; Danese, Silvio; van Hogezand, Ruud A; Panés, Julian; Peña, Salvador Amado; Lukas, Milan; Jewell, Derek P; Schreiber, Stefan; Vermeire, Severine; Sans, Miquel.

Gut; 62(11): 1556-65, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-23263249

19.

Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients.

De Smedt, Julie; Aura, Claudia; Van Kelst, Sofie; Janssen, Laudine; Marasigan, Vivien; Boecxstaens, Veerle; Stas, Marguerite; Bogaerts, Kris; Belmans, Ann; Cleynen, Isabelle; Vanderschueren, Dirk; Vandenberghe, Katleen; Bechter, Oliver; Nikkels, Arjen; Strobbe, Tinne; Emri, Gabriella; Lambrechts, Dieter; Garmyn, Marjan.

Melanoma Res; 34(2): 125-133, 2024 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-38348498

20.

An efficient algorithm to perform multiple testing in epistasis screening.

Van Lishout, François; Mahachie John, Jestinah M; Gusareva, Elena S; Urrea, Victor; Cleynen, Isabelle; Théâtre, Emilie; Charloteaux, Benoît; Calle, Malu Luz; Wehenkel, Louis; Van Steen, Kristel.

BMC Bioinformatics; 14: 138, 2013 Apr 24.

Artículo en Inglés | MEDLINE | ID: mdl-23617239

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