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1.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A;
121(1): e2307086120, 2024 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38147543
2.
Application of Covalent Binding Body Burden in the HµREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs.
Chem Res Toxicol;
37(4): 540-544, 2024 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38530825
3.
Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.
Drug Metab Dispos;
50(8): 1064-1076, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35680134
4.
The influence of the Or and Carotene Hydroxylase genes on carotenoid accumulation in orange carrots [Daucus carota (L.)].
Theor Appl Genet;
134(10): 3351-3362, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34282485
5.
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Bioorg Med Chem Lett;
30(12): 127205, 2020 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32336498
6.
Population genomics identifies genetic signatures of carrot domestication and improvement and uncovers the origin of high-carotenoid orange carrots.
Nat Plants;
9(10): 1643-1658, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37770615
7.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem;
66(4): 2877-2892, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36757100
8.
A Phase 1 First-in-Human Pharmacokinetic and Pharmacodynamic Study of JNJ-64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase.
Clin Pharmacol Drug Dev;
12(6): 611-624, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37125450
9.
Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor.
ACS Chem Neurosci;
14(17): 3059-3076, 2023 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37566734
10.
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem;
65(21): 14326-14336, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36314537
11.
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
ACS Med Chem Lett;
12(5): 782-790, 2021 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34055226
12.
Is News Surveillance related to Cancer Knowledge in Underserved Adults? Testing Three Versions of the Cognitive Mediation Model.
Journal Stud;
21(9): 1186-1199, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33100901
13.
The Genetic Diversity of Cranberry Crop Wild Relatives, Vaccinium macrocarpon Aiton and V. oxycoccos L., in the US, with Special Emphasis on National Forests.
Plants (Basel);
9(11)2020 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33114692
14.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
ACS Med Chem Lett;
11(10): 2002-2009, 2020 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33062185
15.
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
J Med Chem;
63(17): 9181-9196, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787105
16.
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
ACS Med Chem Lett;
10(3): 261-266, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891123
17.
Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.
ACS Med Chem Lett;
10(3): 267-272, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891124
18.
Carotenoid Presence Is Associated with the Or Gene in Domesticated Carrot.
Genetics;
210(4): 1497-1508, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30352832
19.
Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.
ACS Med Chem Lett;
9(8): 821-826, 2018 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30128074
20.
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
J Med Chem;
61(1): 207-223, 2018 01 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29211470