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1.
In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus.
Antimicrob Agents Chemother;
65(10): e0068221, 2021 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34310205
2.
Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors.
Antimicrob Agents Chemother;
64(10)2020 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32660997
3.
The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins.
Biochem Biophys Res Commun;
527(1): 232-237, 2020 06 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-32446373
4.
FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
Biochem Biophys Res Commun;
526(1): 48-54, 2020 05 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32192767
5.
Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.
Biochem Biophys Res Commun;
505(3): 740-746, 2018 11 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30292408
6.
Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus.
J Fungi (Basel);
8(12)2022 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36547614
7.
Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
mBio;
13(3): e0104922, 2022 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35604094
8.
Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.
mBio;
12(6): e0300021, 2021 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34809463
9.
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Nat Commun;
10(1): 4275, 2019 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-31537789
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