RESUMEN
Extensive studies have demonstrated that immune complexes represent an important affidable tumor marker with a significant value as diagnostic and prognostic indicator of malignant diseases. In this view, we have studied a group of 11 healthy donors and a group of 11 patients with gynecological malignancies, pre- and post-operatively. Blood samples stored at -30 degrees C were tested by a new competitive immunoenzymatic assay (C3bi test). The data obtained, showed significant differences between healthy donors and tumor patients (p less than 0.001). Furthermore it is notable that the results obtained pre- and post-operatively could be proved with further longitudinal studies.
Asunto(s)
Complejo Antígeno-Anticuerpo/análisis , Neoplasias Ováricas/inmunología , Neoplasias Uterinas/inmunología , Adulto , Anciano , Femenino , Humanos , Técnicas para Inmunoenzimas , Persona de Mediana Edad , Neoplasias Ováricas/diagnóstico , Neoplasias Ováricas/cirugía , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/cirugíaRESUMEN
In the field of oncology, the most important aim to date has been the finding of new means to improve the diagnosis and treatment of neoplastic diseases. Chronobiologically we have studied the behavior of phosphohexoseisomerase (PHI) in 11 multiple myeloma patients before treatment and in another group of 11 patients undergoing polychemotherapy treatment. From all patients, under the same standard conditions, 6 venous samples were taken at 4-hour intervals starting at 08.00 h, for a day. PHI serum levels were determined spectrophotometrically. The data obtained were analyzed by 'group mean cosinor' and from this analysis a mesor reduction of more than 50% was noted in subjects after polychemotherapy (M2) correlated with the absence of a circadian rhythm. The data suggest that PHI levels can be related to the characteristics of tumor growth and we feel they can be used as a guide in monitoring multiple myeloma patients.
Asunto(s)
Glucosa-6-Fosfato Isomerasa/sangre , Mieloma Múltiple/enzimología , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Ritmo Circadiano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mieloma Múltiple/tratamiento farmacológicoRESUMEN
We report on the possible diagnostic and prognostic role of circulating immune complexes (CIC) determination in breast cancer. A sensitivity of 87% and a specificity of 90% were observed in a case-control study of 15 cancers and 25 noncancer healthy controls. A direct correlation of CIC level to the presence and probably to the entity of the tumor mass was assessed by comparing preoperative to postoperative CIC determinations in cancer cases: CIC levels were significantly lower after tumor removal. These preliminary results suggest further studies on the use of CIC determination in the follow-up of breast cancer for the early diagnosis of recurrent disease.