Health risk assessment and spatial distribution of nitrate, nitrite, fluoride, and coliform contaminants in drinking water resources of kazerun, Iran.

Exposure to nitrate, nitrite, and fluoride through drinking water consumption, especially in arid and semi-arid regions, has been considered by many researchers. Therefore, the present study aimed to investigate the status of nitrate, nitrite, fluoride, and total coliforms in water supply sources of Kazerun located in Fars province, Iran, determine their spatial distribution, and perform health risk assessment in four age groups (infants, children, teenagers, and adults). In this research, the concentration data of 25 groundwater wells were examined. Then, the spatial distribution of the contaminants was determined using the Arc GIS software (v. 10.5) and their health risk assessment was performed via the standard method of the US Environmental Protection Agency. The maximum concentrations of nitrate, nitrite, and fluoride were 25.5, 0.056, and 0.72 mg/l, respectively and their mean concentrations were 13.5, 0.008, and 0.52 mg/l, respectively. In addition, the mean and maximum concentrations of coliforms were 371.21 and 2694.50 CFU/100 ml, respectively. The total coliforms value was higher than the permissible limit in 60 % of the cases. The highest Chronic Daily Intake (CDI) of the studied contaminants was related to nitrate among children (range: 0.21-1.45, with an average value of 0.77 mg/kg-day). Moreover, the Hazard Quotient (HQ) values were below 1 for all contaminants and in all age groups. The highest HQ value (0.9) belonged to nitrate amongst children. Furthermore, the Hazard Index (HI), as a cumulative effect of HQ, was calculated for all three contaminants and the results showed that it was greater than 1 in 56 % of the cases among children, which was considered a serious risk. The findings revealed no significant relationship between nitrate and nitrite concentrations and total coliforms. Overall, nitrate seemed to play a more critical role in the health risk of the exposed age groups in comparison to nitrite and fluoride. Hence, appropriate managerial measures are recommended to be taken.

Health risks of inhalation exposure to BTEX in a municipal wastewater treatment plant in Middle East city: Shiraz, Iran.

Benzene, toluene, ethylbenzene, and xylene, known as BTEX, adversely affect human health. This study aimed to measure BTEX concentration and assess the health risk through inhalation exposure to these compounds in a municipal wastewater treatment plant. The ambient air samples were collected using the active sampling method in summer and winter. Sampling sites were close to wastewater treatment units, including bar screen & grit chamber (Site-1), aeration tank & secondary clarifiers (Site-2), anaerobic sludge digester (Site-3), and office & control building (Site-4). Results indicate that the mean levels of benzene and toluene in winter were higher than in summer. The levels of benzene and toluene were below the occupational exposure levels of the American Conference of Governmental Industrial Hygienists (ACGIH) and Occupational Safety and Health Administration (OSHA). The carcinogenic risk (CR) and hazard quotient (HQ) were assessed using the United States Environmental Protection Agency (U.S.EPA) method, and Monte Carlo simulation (MCS) was applied to quantify the uncertainty and sensitivity analysis. The CRs for all sampling sites were below the U.S.EPA threshold limit (1.0 × 10-4). The HQ values for benzene nearby Site-2 were above 1.0, indicating inhalation exposure could pose a health hazard. Besides, the HQ results for exposure to toluene in all sampling sites were less than 1.0. The sensitivity analysis had shown that the risk determinant for carcinogenic and non-carcinogenic risk was exposure time, followed by concentration.

Health risk assessment of exposure to atrazine in the soil of Shiraz farmlands, Iran.

Atrazine-contaminated soils can pose a carcinogenic and non-carcinogenic health risk through different routes for exposed people. This study aimed to assess the health risk of exposure to atrazine-contaminated soils through direct ingestion and dermal contact in farmlands nearby Shiraz. Atrazine concentration was measured in 22 selected sites using grid sampling. The carcinogenic and non-cancer risks associated with dermal and ingestion exposure in children and adults were estimated. The lowest and highest atrazine concentrations were in S1 (0.015 mg/kg soil) and S22 (0.55 mg/kg soil). Hazard Index (HI)1 values ranged from 0.007 to 0.25 for children, and the values ranged from 0.0008 to 0.03 for adults. The mean cancer risk for children and adults was 6.01 × 10-4 and 7.40 × 10-5, respectively. The HI value was less than 1 for all sampling sites, indicating that exposure to atrazine does not threaten children and adults. However, the cancer risk exceeds the United States Environmental Protection Agency (US.EPA)2 threshold risk limit (10-6 to 10-4) in all sampling sites. Therefore, it is recommended that children should avoid playing on atrazine-contaminated farms or soils near anywhere atrazine may have been used.

Non-carcinogenic risk assessment of exposure to heavy metals in underground water resources in Saraven, Iran: Spatial distribution, monte-carlo simulation, sensitive analysis.

Groundwater aquifers are considered the second most abundant water supply for drinking water all over the world. In Iran, ground waters are commonly employed for drinking water, irrigation, and industrial purposes. Heavy metals (HMs) pose human concerns about the groundwater contamination; these pollutants are recognized to be capable of bio-accumulation, long persistence in the natural environment, and toxic effects. In the present research, the content of HMs: Chromium (Cr), Cadmium (Cd), and Lead (Pb) were detected in 89 water samples collected in 2018 by underground water supplies (active wells) of Saravan city. Hazard Quotient (HQ) and Monte Carlo Simulation approach with 10,000 repetitions were applied to discover the human non-carcinogenic impacts of HMs in four groups of ages (adults, teenagers, children, and infants) of consumers. The concentrations of Cr, Pb, and Cd were in the range of 0.49-20, 0.1 to 58.34, and 0.11-12.8 µg/L, respectively. The mean HQ calculated due to exposure to Pb (0.0018-0.0023), Cr (0.0112-0.0186), and Cd (0.0370-0.0615) were lower than one. The findings of sensitivity analysis revealed that HMs concentration had the most contribution effect on human non-carcinogenic risk analysis in four different exposed populations. This study could assist researchers to perform more comprehensive studies with more samples. Therefore, further research is required for decision-makers to plan proper measurements properly.

Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells.

Humans are exposed to environmental microplastic (MPs) that can be frequent in surrounding environment. The mesenchymal stromal cells are a heterogeneous population, which contain fibroblasts and stromal cells, progenitor cells and stem cells. They are part of the stromal component of most tissue and organs in our organisms. Any injury to their functions may impair tissue renewal and homeostasis. We evaluated the effects of different size MPs that could be present in water bottles on human bone marrow mesenchymal stromal cells (BMMSCs) and adipose mesenchymal stromal cells (AMSCs). MPs of polyethylene terephthalate (MPs-PET) (<1 µm and <2.6 µm) were tested in this study. PET treatments induced a reduction in proliferating cells (around 30%) associated either with the onset of senescence or increase in apoptosis. The AMSCs and BMMSCs exposed to PET showed an alteration of differentiation potential. AMSCs remained in an early stage of adipocyte differentiation as shown by high levels of mRNA for Peroxisome Proliferator Activated Receptor Gamma (PPARG) (7.51 vs 1.00) and reduction in Lipoprotein Lipase (LPL) mRNA levels (0.5 vs 1.0). A loss of differentiation capacity was also observed for the osteocyte phenotype in BMMSCs. In particular, we observed a reduction in Bone Gamma-Carboxy glutamate Protein (BGLAP) (0.4 for PET1 and 0.6 for PET2.6 vs 0.1 CTRL) and reduction in Osteopontin (SPP1) (0.3 for PET 1 and 0.64 for PET 2.6 vs 0.1 CTRL). This pioneering mesenchymal cell response study demonstrated that environmental microplastic could be bioavailable for cell uptake and may further lead to irreversible diseases.

The residual nitrate and nitrite levels in meat products in Iran: A systematic review, meta-analysis and health risk assessment.

This study was designed to investigate the mean residual nitrite and nitrate levels in meat products, in Iran and to evaluate their health-related risks. After reviewing 799 studies, 15 were finally selected, their information was recorded and examined using Stata software. The results of the present study show that the mean residual nitrite and nitrate levels in meat products was about 55.18 and 95.09 ppm, respectively. The residual nitrite level is different in various meat products, so that the residual nitrite level in sausages and kielbasa is 54.52 and 56.87 ppm, respectively. Also, the present study shows that the mean residual nitrate level in sausages and kielbasa was 77.21 and 121.49 ppm, respectively. Health Risk Index (HRI) of nitrite and nitrate were 0.1541 and 0.0050, respectively, which were lower than 1 value. Therefore, there is no considerable carcinogenic risk for consumers in Iran. Taking together, these residues must be continuously monitored by relevant authorities.

A process mining approach in big data analysis and modeling decision making risks for measuring environmental health in institutions.

This paper aimed to introduce a process-mining framework for measuring the status of environmental health in institutions. The methodology developed a new software-based index namely Institutional Environmental Health Index (IEHI) that was integrated from ontology-based Multi-Criteria Group Decision-Making models based on the principles of fuzzy modeling and consensus evaluation. Fuzzy Ordered Weighting Average (OWA) with the capability of modeling the uncertainties and decision-making risks along with Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) were employed as the computation engine. The performance of the extended index was examined through an applied example on 20 mosques as public institutions. IEHI could analyze big data collected by environmental health investigators and convert them to a single and interpretable number. The index detected the mosques with very unsuitable health conditions that should be in priority of sanitation and suitable ones as well. Due to the capability of defining the type and numbers of criteria and benefitting from specific and user-friendly software namely Group Fuzzy Decision-Making, this index is highly flexible and practical. The methodology could be used for numerating the environmental health conditions in any intended institution or occupation. The proposed index would provide e-health assessment by more efficient analysis of big data and risks that make more realistic decisions in environmental health system.

Antibiotic residues in poultry tissues in Iran: A systematic review and meta-analysis.

To control the drug residues in foods, the national Maximum Residue Limits (MRLs) have been determined by the international organizations; however, no regulation has been complied for MRL in food animals in Iran. This study was a systematic review and meta-analysis about studies of antibiotic residues in slaughtered poultry carcasses, in Iran. The information was first collected and analyzed throughout six international databases, and four Iranian national databases. According to the data, the total prevalence of antibiotic residues was obtained as 39.41%, 5.40%, and 0.30% using four-plate test (FPT), High-Performance Liquid Chromatography (HPLC), and Enzyme-linked immuno_sorbent assay (ELISA) methods, respectively. The highest prevalence of the residues was shown in the liver by both methods of HPLC (47.75%) and ELISA (14.35%). Moreover, the total mean of antibiotics was recorded as 71.03 ppb and 65.86 ppb in different tissues using the HPLC and ELISA method, respectively. Based on this study, we can conclude that the prevalence of antibiotic residue in poultry meat in Iran is high and that this level does not cause health problems for consumers. It is highly recommended to execute tight surveillance strategies from the government in antibiotic monitoring.

Embryotoxicity of polystyrene microplastics in zebrafish Daniorerio.

In the recent years, increasing scientific and societal concern has been raised over the presence and accumulation of plastic debris in the environment and the effects of microplastics (MPs) that can easily interact with biota. In order to elucidate the impact of MPs at the critical development stages of freshwater fish species, a fish embryo toxicity test was herein performed on the zebrafish Danio rerio, exposed to 10 µm polystyrene MPs at 200 particles/mL for 120 hpf. After exposure, accumulation of MPs in larvae was measured, survival, hatching and larvae development were monitored and the oxidant/anti-oxidant responses and cellular detoxification evaluated. No impact on survival of developing zebrafish was revealed, but a moderate delay in hatching was observed. Alterations in larvae development were recorded with zebrafish exhibiting serious deformities, mainly at the level of column and tail, as well as a compromised integrity of the visual structure of the eyes. Moreover, increased levels of gene transcription involved in the oxidative stress (sod1, sod2 and cat) and in cellular detoxification (gst and cyp) were also detected in MPs-exposed zebrafish larvae. Overall, this research work provides new insights on the ecotoxicological impact of polystyrene MPs on the critical developmental stages of a freshwater fish species, therefore enhancing the current knowledge of the environmental risk posed by MPs to the aquatic ecosystem.

Bidirectional association between COVID-19 and the environment: A systematic review.

The global crisis caused by SARS-CoV-2 (COVID-19) affected economics, social affairs, and the environment, not to mention public health. It is estimated that near 82% of the SARS-CoV-2 genome is similar to the severe acute respiratory syndrome. The purpose of the review is to highlight how the virus is impacted by the environment and how the virus has impacted the environment. This review was based on an electronic search of the literature in the Scopus, Science Direct, and PubMed database published from December 2019 to July 2020 using combinations of the following keywords: SARS-CoV-2 transmission, COVID-19 transmission, coronavirus transmission, waterborne, wastewater, airborne, solid waste, fomites, and fecal-oral transmission. Studies suggest the thermal properties of ambient air, as well as relative humidity, may affect the transmissibility and viability of the virus. Samples taken from the wastewater collection network were detected contaminated with the novel coronavirus; consequently, there is a concern of its transmission via an urban sewer system. There are concerns about the efficacy of the wastewater treatment plant disinfection process as the last chance to inactivate the virus. Handling solid waste also requires an utmost caution as it may contain infectious masks, etc. Following the PRISMA approach, among all reviewed studies, more than 36% of them were directly or indirectly related to the indoor and outdoor environment, 16% to meteorological factors, 11% to wastewater, 14% to fomites, 8% to water, 9% to solid waste, and 6% to the secondary environment. The still growing body of literature on COVID-19 and air, suggests the importance of SARS-CoV-2 transmission via air and indoor air quality, especially during lockdown interventions. Environmental conditions are found to be a factor in transmitting the virus beyond geographical borders. Accordingly, countries need to pay extra attention to sustainable development themes and goals.

Spatial distribution and correlations among elements in smaller than 75 µm street dust: ecological and probabilistic health risk assessment.

This study aimed to investigate spatial distribution, correlations among elements and ecological and probabilistic health risk assessment in smaller than 75 µm street dust in Kerman city, Iran. Street dust samples were collected from 35 different points. Elements were detected by ICP-AES. Pollution degree was characterized through Enrichment Factor (EF), Contamination Factor (CF), Geo-accumulation Index (Igeo) and Potential Ecological Risk (PER). The health risk was assessed using the Monte Carlo simulation method. The mean values of elements were in the order of Al > Mn > Zn > Cu > V > Pb > Cr > Ni > Li > As > Co > Mo > Sb > Cd > Ag. The results of Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) showed that Al, As, Co, Li, Mn and V were possibly derived from natural sources (local soil), while traffic and mining activities were proposed as the main source of Cd, Cr, Cu, Mo, Ni, Pb, Sb and Zn. The order of EF and CF mean values decreased as follows: Mn > Ag > Cu > Zn > Pb > Sb > Mo > Li > Co > V > Cd > As > Cr > Ni. In addition, 73% of Cu and 35% of Zn, Ag and Mn had significant enrichment in the street dust samples. Also, Ag and Mn were categorized in the significant and very significant pollution category. In terms of the PER index, all samples could be classified at low-risk category. Ingestion of street dust was the significant route for exposure of residents of Kerman to the elements studied. No significant ecological hazards and health risks were observed from street dust in the study area in the period of the study. The improvement in the fuels quality and development of green spaces can be suggested to control natural and anthropogenic street dust pollution sources in the Kerman city.

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review.

A new coronavirus (SARS-CoV-2) has determined a pneumonia outbreak in China (Wuhan, Hubei Province) in December 2019, called COVID-19 disease. In addition to the person-to person transmission dynamic of the novel respiratory virus, it has been recently studied the role of environmental factors in accelerate SARS-CoV-2 spread and its lethality. The time being, air pollution has been identified as the largest environmental cause of disease and premature death in the world. It affects body's immunity, making people more vulnerable to pathogens. The hypothesis that air pollution, resulting from a combination of factors such as meteorological data, level of industrialization as well as regional topography, can acts both as a carrier of the infection and as a worsening factor of the health impact of COVID-19 disease, has been raised recently. With this review, we want to provide an update state of art relating the role of air pollution, in particular PM2.5, PM10 and NO2, in COVID-19 spread and lethality. The Authors, who first investigated this association, often used different research methods or not all include confounding factors whenever possible. In addition, to date incidence data are underestimated in all countries and to a lesser extent also mortality data. For this reason, the cases included in the reviewed studies cannot be considered conclusive. Although it determines important limitations for direct comparison of results, and more studies are needed to strengthen scientific evidences and support firm conclusions, major findings are consistent, highlighting the important contribution of PM2.5 and NO2 as triggering of the COVID-19 spread and lethality, and with a less extent also PM10, although the potential effect of airborne virus exposure it has not been still demonstrated.

Unraveling the interplay between environmental microplastics and salinity stress on Mytilus galloprovincialis larval development: A holistic exploration.

The rise of plastic production has triggered a surge in plastic waste, overwhelming marine ecosystems with microplastics. The effects of climate change, notably changing salinity, have shaped the dynamics of coastal lagoons. Thus, understanding the combined impact of these phenomena on marine organisms becomes increasingly crucial. To address these knowledge gaps, we investigated for the first time the interactive effects of environmental microplastics (EMPs) and increased salinity on the early development of Mytilus galloprovincialis larvae. Morphological assessments using the larval embryotoxicity test revealed larval anomalies and developmental arrests induced by EMPs and increased salinity. Transcriptomic analyses targeting 12 genes involved in oxidative stress, apoptosis, DNA repair, shell formation, and stress proteins were conducted on D-larvae uncovered the potential effects of EMPs on shell biomineralization, highlighting the role of Histidine Rich Glycoproteine (HRG) and tubulin as crucial adaptive mechanisms in Mytilus sp. in response to environmental shifts. Furthermore, we explored oxidative stress and neurotoxicity using biochemical assays. Our findings revealed a potential interaction between EMPs and increased salinity, impacting multiple physiological processes in mussel larvae. Our data contribute to understanding the cumulative effects of emerging anthropogenic pollutants and environmental stressors, emphasizing the need for a holistic approach to assessing their impact on marine ecosystems.

Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review.

Endocrine-disrupting chemicals (EDCs) are a growing public health concern worldwide. Consumption of foodstuffs is currently thought to be one of the principal exposure routes to EDCs. However, alternative ways of human exposure are through inhalation of chemicals and dermal contact. These compounds in food products such as canned food, bottled water, dairy products, fish, meat, egg, and vegetables are a ubiquitous concern to the general population. Therefore, understanding EDCs' properties, such as origin, exposure, toxicological impact, and legal aspects are vital to control their release to the environment and food. The present paper provides an overview of the EDCs and their possible disrupting impact on the endocrine system and other organs.

Evaluation of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in Mullus barbatus from Sicily Channel and risk-based consumption limits.

Our study is a preliminary step to evaluate water contamination of the Mediterranean Sea surrounding Lampedusa island and health risks for fish consumers. We analyzed muscle tissue of Mullus barbatus specimens to detect metals and polycyclic aromatic hydrocarbons (PAHs). Results show the following average concentrations of heavy metals: Pb 0.035, Cd 0.001, Hg 0.027, Cr 0.524, As 27.01, Cu 0.433, Co 0.013, Ni 0.042, Se 0.487, V 0.072, U 0.055 and Zn 3.360 ppm. PAHs ranged from 0.250 to 13.16 ppb. A possible risk to human health was determined based on consumption limits data and the content of total PAHs in fillets of this species.

Effects of Nano and Microplastics on the Inflammatory Process: In Vitro and In Vivo Studies Systematic Review.

BACKGROUND: Microplastics (MPs) and Nanoplastics (NPs) are plastic fragments that spread in the environment and accumulate in the human body, so they have been becoming a worldwide environmental concern because of their potential human health effects. The aim of this systematic review was to investigate the prospective impact of MPs and NPs on the inflammatory process. METHODS: Electronic article search was performed on PubMed, Scopus and Web of Science international databases from 1 Jan 2012 to 31 Dec 2021. Screenings of titles, abstracts and full texts were performed according to the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA). The methodological quality of the studies was checked by the Toxicological data Reliability Assessment Tool. RESULTS: Electronic article search identified 125 records, from which 6 in vitro, 11 in vivo and 2 both in vivo and in vitro studies were included. Both in vivo and in vitro studies have showed an increase ofdifferent inflammatory outcomes (Interleukines, Tumor necrosis factor, Chemokines, Interferones, Transcription factors, Growth factors, Oxydoreductase, Proteins and others), thus it seems to confirm the association withthe exposure to microplastics of different types, sizes, exposure times and exposed species. CONCLUSIONS: This systematic review seems to support the relationship between the exposure to MPs and the inflammatory processboth in vivo and in vitro. Greater caution is needed about the role of NPs because ofa very small number of studies. Additional high-quality studies are warranted to confirm these results, especially the research should be focused on NPs being lacking literature.

Chemical Characterization and Quantification of Titanium Dioxide Nanoparticles (TiO2-NPs) in Seafood by Single-Particle ICP-MS: Assessment of Dietary Exposure.

The significant increase in the production and variety of nanoparticles (NPs) has led to their release into the environment, especially into the marine environment. Titanium dioxide nanoparticles (TiO2-NPs) are used in different industrial sectors, from the food industry to several consumer and household products. Since the aquatic environment is highly sensitive to contamination by TiO2-NPs, this work aimed to give a preliminary assessment of the contamination of packaged seafood, where the food additive TiO2 (E171) is not to be intentionally added. This allowed providing a chemical characterization and quantification of TiO2-NPs in processed canned fish products belonging to different trophic positions of the pelagic compartment and in canned clam. The new emerging technique called single-particle inductively coupled plasma mass spectrometry (spICP-MS) was applied, which allows the determination of nanoparticle number-based concentration, as well as the dissolved titanium. This study highlights how processed food, where the pigment E171 was not intentionally added, contains TiO2 in its nanoparticle form, as well as dissolved titanium. Processed clam represented the seafood with the highest content of TiO2-NPs. In pelagic fish species, we found progressively higher levels and smaller sizes of TiO2-NPs from smaller to larger fish. Our results highlight the importance of planning the characterization and quantification of TiO2-NPs in food both processed and not, as well as where the pigment E171 is intentionally added and not, as it is not the only source of TiO2-NPs. This result represents a solid step toward being able to estimate the real level of dietary exposure to TiO2-NPs for the general population and the related health risks.

Evaluation of dioxin-like polychlorinated biphenyls in fish of the Caspian Sea.

Dioxin-like polychlorinated biphenyls (DL-PCBs) have toxic properties for humans. The innovation of this study was that for the first time in Iran, 12 DL-PCBs concentration in 5 fish species: Rutilus frisii kutum kanesky, Chelon saliens, Vimba vimba, Cyprinus carpio and Oncorhynchus mykiss, from 5 coastal areas of the Caspian Sea (125 samples), were investigated. DL-PCBs extraction was in accordance to USEPA method 1668 revision A and carry out by chromatography columns modified with silica gel. DL-PCBs concentration were measured by HRGC (Agilent 6890 Series, Agilent Technologies, USA) coupled with HRMS AutoSpec Ultima NT-HRGC/HRMS (Micromass, USA), equipped with the HP-5MS 30 m × 0.25 mm × 0.25 µm column (Agilent Technologies) and helium as carrier gas. The mean concentration of DL-PCBs in samples ranged 232 ± 16-1156 ± 14 pg/g fat, that was in accordance with the Joint FAO/WHO Expert Committee on Food Additives and European Standards. The highest concentration was in Cyprinus carpio of Bandar Anzali, and lowest obtained in samples from Chalous. However, based on fish consuming and fish originating from the fishing area the health risk evaluation to estimate the potential consequences of chronic exposure to DL-PCBs for consumers is recommended and effective measure for health risk reduction.

Inter-Relationship between Platelet-Derived Microparticles and Oxidative Stress in Patients with Venous Thromboembolism.

BACKGROUND: Hypercoagulative conditions play a key role in venous thromboembolism (VTE). Inflammation is currently linked to VTE, but the potential role of circulating microparticles and oxidative stress (OxS) must be elucidated. The aim of this study was to evaluate platelet-derived microparticles and surrogate OxS biomarkers in patients diagnosed with VTE through a case-control study. METHODS: Platelet-derived microparticles (MPs), pro-thrombinase-induced clotting time assay (PiCT), phospholipids (PLPs), malondialdehyde (MDA), 4-hydroxynonenale (4-HNE), thiobarbituric acid reactive substances (TBARs), superoxide dismutase (SOD), and galectin-3 (Gal-3) were measured in VTE patients and in healthy controls. RESULTS: PLPs, 4-HNE, TBARs, and Gal-3 were higher in VTE patients compared to controls; conversely, SOD was lower. A significant non-linear regression between OxS biomarkers and the markers of platelet degranulation was found. CONCLUSION: Our results suggest that OxS and platelet degranulation are concomitant pathophysiological mechanisms in VTE.

Neonatal Systemic Thrombosis: An Updated Overview.

Thromboembolic disease is a complex disorder with a multifactorial aetiology and a severe outcome. In newborns and children it may be missed or diagnosed late, thus worsening the prognosis. The neonatal disease is different from the disorder affecting older children and adults. However, scant epidemiological data and few randomised clinical trials regarding paediatric patients are available, and treatment recommendations are largely based on adult guidelines. Younger patients then have several decades over which they will suffer from the complications of thrombosis and risk of a new thrombotic episode. Current knowledge about neonatal thromboembolic disease and its prevention is reviewed here along with maternal, foetal, neonatal, pharmacological, environmental, lifestyle and occupational contributing factors. Additional data are urgently needed to improve diagnostic and therapeutic strategies and patient outcomes.