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1.
Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor.
J Org Chem;
87(4): 2075-2086, 2022 02 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34652911
2.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
J Med Chem;
67(4): 3090-3111, 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38306388
3.
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
J Med Chem;
66(1): 384-397, 2023 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36525250
4.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett;
22(17): 5563-8, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22858142
5.
The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.
Bioorg Med Chem Lett;
21(5): 1376-81, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21300546
6.
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J Med Chem;
63(24): 15564-15590, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306391
7.
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
J Med Chem;
62(24): 11004-11018, 2019 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31710489
8.
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J Med Chem;
60(8): 3438-3450, 2017 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28376306
9.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem;
55(14): 6363-74, 2012 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22742641
10.
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem;
55(20): 8827-37, 2012 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22984809
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