Differences in V[Combining Dot Above]O2peak of Surfers When Paddling in Water vs. on a Swimbench Ergometer.

Furr, HN, Warner, ME, Copeland, TL, Robles-Rodríguez, C, Ponce-González, JG, Nessler, JA, and Newcomer, SC. Differences in V[Combining Dot Above]O2peak of surfers when paddling in water vs. on a swimbench ergometer. J Strength Cond Res 33(4): 1095-1101, 2019-The purpose of this study was to test the hypothesis that surfers would achieve a higher V[Combining Dot Above]O2peak when tested in a swim flume vs. on a swimbench ergometer. Forty-eight surfers (male: 38, female: 10) aged 18-45 years participated in the study. Protocol 1 and 2 both measured heart rate, oxygen consumption (V[Combining Dot Above]O2), and respiratory exchange ratio while subjects performed an incremental paddling test both on a swimbench ergometer and in a swim flume. Protocol 2 additionally measured muscle activity and changes in skin temperature. V[Combining Dot Above]O2peak was significantly higher in the swim flume (33.03 ± 1.04 ml·kg·min) vs. on the swimbench ergometer (29.86 ± 1.08 ml·kg·min) (p value < 0.001). There were also significant differences in muscle activation and changes in skin temperature between the flume and ergometer (p-value < 0.05). Surfers significantly increased their V[Combining Dot Above]O2peak in the water suggesting previous reports of V[Combining Dot Above]O2peak likely underestimated surfer's aerobic fitness when measured on a swimbench ergometer. Future research investigating the aerobic fitness of surfers should be conducted while paddling in water or account for the 11% difference in V[Combining Dot Above]O2peak when tested on a swimbench ergometer.

Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory.

The hippocampus contains one of the few neurogenic niches within the adult brain-the subgranular zone of the dentate gyrus. The functional significance of adult-born neurons in this region has been characterized using context fear conditioning, a Pavlovian paradigm in which animals learn to associate a location with danger. Ablation or silencing of adult-born neurons impairs both acquisition and recall of contextual fear conditioning, suggesting that these neurons contribute importantly to hippocampal memory. Lesion studies indicate that CFC depends on neural activity in both the dorsal and ventral hippocampus, subregions with unique extrahippocampal connectivity and behavioral functions. Because most studies of adult neurogenesis have relied on methods that permanently ablate neurogenesis throughout the entire hippocampus, little is known about how the function of adult-born neurons varies along the dorsal-ventral axis. Using a Nestin-CreERT2 mouse line to target the optogenetic silencer Archaerhodopsin to adult-born neurons, we compared the contribution of dorsal and ventral adult-born neurons to acquisition, recall, and generalization of CFC. Acquisition of CFC was impaired when either dorsal or ventral adult-born neurons were silenced during training. Silencing dorsal or ventral adult-born neurons during test sessions decreased context-evoked freezing but did not impair freezing in a hippocampus-independent tone-shock freezing paradigm. Silencing adult-born neurons modestly reduced generalization of fear. Our data indicate that adult-born neurons in the dorsal and ventral hippocampus contribute to both memory acquisition and recall. The comparatively large behavioral effects of silencing a small number of adult-born neurons suggest that these neurons make a unique and powerful contribution to hippocampal function.