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1.
Curr Cardiol Rep ; 25(7): 641-648, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-37269474

RESUMEN

PURPOSE OF REVIEW: Myocarditis is an inflammation of the myocardium secondary to a variety of agents such as infectious pathogens, toxins, drugs, and autoimmune disorders. In our review, we provide an overview of miRNA biogenesis and their role in the etiology and pathogenesis of myocarditis, evaluating future directions for myocarditis management. RECENT FINDINGS: Advances in genetic manipulation techniques allowed to demonstrate the important role of RNA fragments, especially microRNAs (miRNAs), in cardiovascular pathogenesis. miRNAs are small non-coding RNA molecules that regulate the post-transcriptional gene expression. Advances in molecular techniques allowed to identify miRNA's role in pathogenesis of myocarditis. miRNAs are related to viral infection, inflammation, fibrosis, and apoptosis of cardiomyocytes, making them not only promising diagnostic markers but also prognostics and therapeutic targets in myocarditis. Of course, further real-world studies will be needed to assess the diagnostic accuracy and applicability of miRNA in the myocarditis diagnosis.


Asunto(s)
MicroARNs , Miocarditis , Humanos , MicroARNs/genética , MicroARNs/metabolismo , Miocarditis/diagnóstico , Miocarditis/genética , Miocardio/patología , Miocitos Cardíacos/patología , Inflamación
3.
G Ital Cardiol (Rome) ; 24(11): 866-871, 2023 Nov.
Artículo en Italiano | MEDLINE | ID: mdl-37901977

RESUMEN

Left ventricular non compaction (LVNC) comprises a heterogeneous group of diseases that can cause heart failure, arrhythmias, and thromboembolic events. In particular, the prevalence of thromboembolism in patients with LVNC is relevant compared to the general population. Atrial fibrillation and left ventricular thrombosis are strong predictors and require anticoagulant treatment in primary or secondary prevention, with a significant reduction in the risk of events. Long-term oral anticoagulation can be considered in patients with LVNC associated with left ventricular systolic dysfunction and sinus rhythm. On the contrary, it is not entirely clear whether the presence of deep intertrabecular recesses that cause blood flow stagnation can itself represent a thrombogenic substrate even in the absence of ventricular dysfunction and in sinus rhythm, thus indicating the use of anticoagulation.This article addresses the open question of the indication for anticoagulant therapy in LVNC, through a review of the current evidence on thromboembolic risk stratification and the initiation of anticoagulant therapy and by proposing a flow-chart as a guide to decision-making according to the clinical picture of the patient.


Asunto(s)
Fibrilación Atrial , Insuficiencia Cardíaca , Tromboembolia , Disfunción Ventricular Izquierda , Humanos , Anticoagulantes/uso terapéutico , Disfunción Ventricular Izquierda/complicaciones , Disfunción Ventricular Izquierda/tratamiento farmacológico , Fibrilación Atrial/complicaciones , Fibrilación Atrial/tratamiento farmacológico , Ventrículos Cardíacos , Tromboembolia/etiología , Tromboembolia/prevención & control
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