A Bis-Triazacyclononane Tris-Pyridyl N9 -Azacryptand "Beer Can" Receptor for Complexation of Alkali Metal and Lead(II) Cations.

A new bis-triazacyclononane tris-pyridyl N9 -azacryptand ligand is prepared via a convenient one-pot [2+3] condensation reaction between triazacyclononane and 2,6-bis(bromomethyl) pyridine in the presence of M2 CO3 (M=Li, Na, K). The proton, lithium, sodium, potassium and lead(II) complexes of the ligand are characterised in the solid state. Preliminary solution-phase competition experiments indicate that the cryptand ligand preferentially binds lead(II) in the presence of sodium, calcium, potassium and zinc cations in methanol solution.

Assembly of polyamines via amino acids from three components using cobalt(III) template methodology.

A versatile and efficient template synthesis has been developed to synthesise novel polyamines [e.g. rac-N3-(3-aminopropyl)butane-1,3-diamine, isospermidine 1] via amino acids [e.g. (2R,4S/2S,4R)-N4-(3-aminopropyl)-2,4-diaminopentanoic acid] using cobalt(III) to assemble the three precursor components in a biomimetic manner.