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1.

Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53.

Long, Jaclyn S; Crighton, Diane; O'Prey, James; Mackay, Gillian; Zheng, Liang; Palmer, Timothy M; Gottlieb, Eyal; Ryan, Kevin M.

Mol Cell; 50(3): 394-406, 2013 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-23603120

2.

A novel small-molecule MRCK inhibitor blocks cancer cell invasion.

Unbekandt, Mathieu; Croft, Daniel R; Crighton, Diane; Mezna, Mokdad; McArthur, Duncan; McConnell, Patricia; Schüttelkopf, Alexander W; Belshaw, Simone; Pannifer, Andrew; Sime, Mairi; Bower, Justin; Drysdale, Martin; Olson, Michael F.

Cell Commun Signal; 12: 54, 2014 Oct 05.

Artículo en Inglés | MEDLINE | ID: mdl-25288205

3.

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

Bell, Helen S; Dufes, Christine; O'Prey, Jim; Crighton, Diane; Bergamaschi, Daniele; Lu, Xin; Schätzlein, Andreas G; Vousden, Karen H; Ryan, Kevin M.

J Clin Invest; 117(4): 1008-18, 2007 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-17347683

4.

A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.

Birch, Joanna L; Strathdee, Karen; Gilmour, Lesley; Vallatos, Antoine; McDonald, Laura; Kouzeli, Ariadni; Vasan, Richa; Qaisi, Abdulrahman Hussain; Croft, Daniel R; Crighton, Diane; Gill, Kathryn; Gray, Christopher H; Konczal, Jennifer; Mezna, Mokdad; McArthur, Duncan; Schüttelkopf, Alexander W; McConnell, Patricia; Sime, Mairi; Holmes, William M; Bower, Justin; McKinnon, Heather J; Drysdale, Martin; Olson, Michael F; Chalmers, Anthony J.

Cancer Res; 78(22): 6509-6522, 2018 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-30279244

5.

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.

Unbekandt, Mathieu; Belshaw, Simone; Bower, Justin; Clarke, Maeve; Cordes, Jacqueline; Crighton, Diane; Croft, Daniel R; Drysdale, Martin J; Garnett, Mathew J; Gill, Kathryn; Gray, Christopher; Greenhalgh, David A; Hall, James A M; Konczal, Jennifer; Lilla, Sergio; McArthur, Duncan; McConnell, Patricia; McDonald, Laura; McGarry, Lynn; McKinnon, Heather; McMenemy, Carol; Mezna, Mokdad; Morrice, Nicolas A; Munro, June; Naylor, Gregory; Rath, Nicola; Schüttelkopf, Alexander W; Sime, Mairi; Olson, Michael F.

Cancer Res; 78(8): 2096-2114, 2018 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-29382705

6.

p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death.

Baudot, Alice D; Crighton, Diane; O'Prey, Jim; Somers, Joanna; Sierra Gonzalez, Pablo; Ryan, Kevin M.

Cell Cycle; 15(17): 2299-308, 2016 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-27315169

7.

Several regions of p53 are involved in repression of RNA polymerase III transcription.

Stein, Torsten; Crighton, Diane; Warnock, Lorna J; Milner, Jo; White, Robert J.

Oncogene; 21(36): 5540-7, 2002 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-12165852

8.

RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.

Stein, Torsten; Crighton, Diane; Boyle, John M; Varley, Jennifer M; White, Robert J.

Oncogene; 21(19): 2961-70, 2002 May 02.

Artículo en Inglés | MEDLINE | ID: mdl-12082526

9.

Splicing DNA-damage responses to tumour cell death.

Crighton, Diane; Ryan, Kevin M.

Biochim Biophys Acta; 1705(1): 3-15, 2004 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-15585169

10.

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties.

Charles, Mark D; Brookfield, Joanna L; Ekwuru, Tennyson C; Stockley, Martin; Dunn, John; Riddick, Michelle; Hammonds, Tim; Trivier, Elisabeth; Greenland, Gavin; Wong, Ai Ching; Cheasty, Anne; Boyd, Susan; Crighton, Diane; Olson, Michael F.

J Med Chem; 58(20): 8309-13, 2015 Oct 22.

Artículo en Inglés | MEDLINE | ID: mdl-26356364

11.

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.

Mardilovich, Katerina; Baugh, Mark; Crighton, Diane; Kowalczyk, Dominika; Gabrielsen, Mads; Munro, June; Croft, Daniel R; Lourenco, Filipe; James, Daniel; Kalna, Gabriella; McGarry, Lynn; Rath, Oliver; Shanks, Emma; Garnett, Mathew J; McDermott, Ultan; Brookfield, Joanna; Charles, Mark; Hammonds, Tim; Olson, Michael F.

Oncotarget; 6(36): 38469-86, 2015 Nov 17.

Artículo en Inglés | MEDLINE | ID: mdl-26540348

12.

Trailblazing LIM kinases take the lead in collective tumor cell invasion.

Crighton, Diane; Olson, Michael F.

Bioarchitecture; 1(1): 5-8, 2011 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-21866254

13.

Modeling and imaging 3-dimensional collective cell invasion.

Scott, Rebecca W; Crighton, Diane; Olson, Michael F.

J Vis Exp; (58)2011 Dec 07.

Artículo en Inglés | MEDLINE | ID: mdl-22157886

14.

Co-crystal structures of inhibitors with MRCKß, a key regulator of tumor cell invasion.

Heikkila, Timo; Wheatley, Edward; Crighton, Diane; Schroder, Ewald; Boakes, Alexandra; Kaye, Sarah J; Mezna, Mokdad; Pang, Leon; Rushbrooke, Mathew; Turnbull, Andrew; Olson, Michael F.

PLoS One; 6(9): e24825, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21949762

15.

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.

Croft, Daniel R; Crighton, Diane; Samuel, Michael S; Lourenco, Filipe C; Munro, June; Wood, Jenifer; Bensaad, Karim; Vousden, Karen H; Sansom, Owen J; Ryan, Kevin M; Olson, Michael F.

Cell Res; 21(4): 666-82, 2011 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-21079653

16.

p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.

O'Prey, Jim; Crighton, Diane; Martin, Angel G; Vousden, Karen H; Fearnhead, Howard O; Ryan, Kevin M.

Cell Cycle; 9(5): 947-52, 2010 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-20160496

17.

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

Scott, Rebecca W; Hooper, Steven; Crighton, Diane; Li, Ang; König, Ireen; Munro, June; Trivier, Elisabeth; Wickman, Grant; Morin, Pierre; Croft, Daniel R; Dawson, John; Machesky, Laura; Anderson, Kurt I; Sahai, Erik A; Olson, Michael F.

J Cell Biol; 191(1): 169-85, 2010 Oct 04.

Artículo en Inglés | MEDLINE | ID: mdl-20876278

18.

Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B.

Martin, Angel G; Trama, Jason; Crighton, Diane; Ryan, Kevin M; Fearnhead, Howard O.

Aging (Albany NY); 1(3): 335-49, 2009 Feb 18.

Artículo en Inglés | MEDLINE | ID: mdl-20195489

19.

DRAM links autophagy to p53 and programmed cell death.

Crighton, Diane; Wilkinson, Simon; Ryan, Kevin M.

Autophagy; 3(1): 72-4, 2007.

Artículo en Inglés | MEDLINE | ID: mdl-17102582

20.

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.

Crighton, Diane; Wilkinson, Simon; O'Prey, Jim; Syed, Nelofer; Smith, Paul; Harrison, Paul R; Gasco, Milena; Garrone, Ornella; Crook, Tim; Ryan, Kevin M.

Cell; 126(1): 121-34, 2006 Jul 14.

Artículo en Inglés | MEDLINE | ID: mdl-16839881

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