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1.
Mar Drugs ; 17(8)2019 Jul 27.
Artículo en Inglés | MEDLINE | ID: mdl-31357591

RESUMEN

Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4ß-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.


Asunto(s)
Glucosa/metabolismo , Poríferos/química , Antígeno Prostático Específico/metabolismo , Esteroides/química , Esteroides/farmacología , Sulfatos/química , Sulfatos/farmacología , Animales , Humanos , Espectroscopía de Resonancia Magnética/métodos , Células PC-3 , Esteroles/química , Esteroles/farmacología , Vietnam
2.
Chemosphere ; 282: 131009, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34091298

RESUMEN

This study investigated methyl orange (MO) dye adsorption using three biochars produced from agro-waste and invasive plants; the latter consisted of wattle bark (BA), mimosa (BM), and coffee husks (BC). BC had the lowest specific surface area (2.62 m2/g) compared to BA (393.15 m2/g) and BM (285.53 m2/g). The adsorption efficiency of MO was stable at pH 2-7 (95%-96%), whilst it had reduced stability at pH 7-12. Between 0 and 30 min, MO adsorption efficiency was >82%, and at 120 min, representative adsorption equilibrium had occurred. The maximum adsorption capacity of the biochars was 12.3 mg/g. The underlying adsorption mechanisms of the three biochars were governed by electrostatic adsorption and pore diffusion. There was an abundance of active sites for adsorption in BA and BM, while chemical adsorption appeared to be more vital for BC, as it contained more functional groups on its surface. The highest MO adsorption efficiency occurred with BM. BC was not recommended for MO removal, as it was observed to stain the water when a dose exceeding 5.0 g/L was utilized.


Asunto(s)
Contaminantes Químicos del Agua , Agua , Adsorción , Cationes , Carbón Orgánico , Cinética , Contaminantes Químicos del Agua/análisis
3.
Steroids ; 104: 246-51, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26476184

RESUMEN

Four new polyoxygenated sterol derivatives (1-4) along with the compounds (5-7) previously known from other biological sources were isolated from the gorgonian Menella woodin, collected from the Vietnamese waters. Structures of 1-4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as comparison with those reported in literature data. Compounds 1, 4, and 6 decrease the production of reactive oxygen species (ROS) by the murine macrophages of RAW 264.7 line at induction by endotoxic lipopolysaccharide (LPS) from Escherichia coli.


Asunto(s)
Antozoos/química , Lipopolisacáridos/farmacología , Macrófagos/efectos de los fármacos , Macrófagos/metabolismo , Especies Reactivas de Oxígeno/metabolismo , Esteroides/farmacología , Animales , Línea Celular , Supervivencia Celular/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Ratones , Conformación Molecular , Especies Reactivas de Oxígeno/antagonistas & inhibidores , Esteroides/química , Esteroides/aislamiento & purificación , Relación Estructura-Actividad
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