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1.

APOE3ch alters microglial response and suppresses Aß-induced tau seeding and spread.

Chen, Yun; Song, Sihui; Parhizkar, Samira; Lord, Jennifer; Zhu, Yiyang; Strickland, Michael R; Wang, Chanung; Park, Jiyu; Tabor, G Travis; Jiang, Hong; Li, Kevin; Davis, Albert A; Yuede, Carla M; Colonna, Marco; Ulrich, Jason D; Holtzman, David M.

Cell; 187(2): 428-445.e20, 2024 01 18.

Artículo en Inglés | MEDLINE | ID: mdl-38086389

2.

Hallmarks of neurodegenerative diseases.

Wilson, David M; Cookson, Mark R; Van Den Bosch, Ludo; Zetterberg, Henrik; Holtzman, David M; Dewachter, Ilse.

Cell; 186(4): 693-714, 2023 02 16.

Artículo en Inglés | MEDLINE | ID: mdl-36803602

3.

Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.

Hoi, David M; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M E; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim.

Cell; 186(10): 2176-2192.e22, 2023 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-37137307

4.

Mapping the long road to cancer.

Cheek, David M; Naxerova, Kamila.

Cell; 185(6): 939-940, 2022 03 17.

Artículo en Inglés | MEDLINE | ID: mdl-35263624

5.

mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.

Pagán, Antonio J; Lee, Lauren J; Edwards-Hicks, Joy; Moens, Cecilia B; Tobin, David M; Busch-Nentwich, Elisabeth M; Pearce, Erika L; Ramakrishnan, Lalita.

Cell; 185(20): 3720-3738.e13, 2022 09 29.

Artículo en Inglés | MEDLINE | ID: mdl-36103894

6.

BacPROTACs mediate targeted protein degradation in bacteria.

Morreale, Francesca E; Kleine, Stefan; Leodolter, Julia; Junker, Sabryna; Hoi, David M; Ovchinnikov, Stepan; Okun, Anastasia; Kley, Juliane; Kurzbauer, Robert; Junk, Lukas; Guha, Somraj; Podlesainski, David; Kazmaier, Uli; Boehmelt, Guido; Weinstabl, Harald; Rumpel, Klaus; Schmiedel, Volker M; Hartl, Markus; Haselbach, David; Meinhart, Anton; Kaiser, Markus; Clausen, Tim.

Cell; 185(13): 2338-2353.e18, 2022 06 23.

Artículo en Inglés | MEDLINE | ID: mdl-35662409

7.

Fundamental behaviors emerge from simulations of a living minimal cell.

Thornburg, Zane R; Bianchi, David M; Brier, Troy A; Gilbert, Benjamin R; Earnest, Tyler M; Melo, Marcelo C R; Safronova, Nataliya; Sáenz, James P; Cook, András T; Wise, Kim S; Hutchison, Clyde A; Smith, Hamilton O; Glass, John I; Luthey-Schulten, Zaida.

Cell; 185(2): 345-360.e28, 2022 01 20.

Artículo en Inglés | MEDLINE | ID: mdl-35063075

8.

TREM2 drives microglia response to amyloid-ß via SYK-dependent and -independent pathways.

Wang, Shoutang; Sudan, Raki; Peng, Vincent; Zhou, Yingyue; Du, Siling; Yuede, Carla M; Lei, Tingting; Hou, Jinchao; Cai, Zhangying; Cella, Marina; Nguyen, Khai; Poliani, Pietro L; Beatty, Wandy L; Chen, Yun; Cao, Siyan; Lin, Kent; Rodrigues, Cecilia; Ellebedy, Ali H; Gilfillan, Susan; Brown, Gordon D; Holtzman, David M; Brioschi, Simone; Colonna, Marco.

Cell; 185(22): 4153-4169.e19, 2022 10 27.

Artículo en Inglés | MEDLINE | ID: mdl-36306735

9.

An ancestral mycobacterial effector promotes dissemination of infection.

Saelens, Joseph W; Sweeney, Mollie I; Viswanathan, Gopinath; Xet-Mull, Ana María; Jurcic Smith, Kristen L; Sisk, Dana M; Hu, Daniel D; Cronin, Rachel M; Hughes, Erika J; Brewer, W Jared; Coers, Jörn; Champion, Matthew M; Champion, Patricia A; Lowe, Craig B; Smith, Clare M; Lee, Sunhee; Stout, Jason E; Tobin, David M.

Cell; 185(24): 4507-4525.e18, 2022 11 23.

Artículo en Inglés | MEDLINE | ID: mdl-36356582

10.

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.

Yang, Dian; Jones, Matthew G; Naranjo, Santiago; Rideout, William M; Min, Kyung Hoi Joseph; Ho, Raymond; Wu, Wei; Replogle, Joseph M; Page, Jennifer L; Quinn, Jeffrey J; Horns, Felix; Qiu, Xiaojie; Chen, Michael Z; Freed-Pastor, William A; McGinnis, Christopher S; Patterson, David M; Gartner, Zev J; Chow, Eric D; Bivona, Trever G; Chan, Michelle M; Yosef, Nir; Jacks, Tyler; Weissman, Jonathan S.

Cell; 185(11): 1905-1923.e25, 2022 05 26.

Artículo en Inglés | MEDLINE | ID: mdl-35523183

11.

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.

Tcw, Julia; Qian, Lu; Pipalia, Nina H; Chao, Michael J; Liang, Shuang A; Shi, Yang; Jain, Bharat R; Bertelsen, Sarah E; Kapoor, Manav; Marcora, Edoardo; Sikora, Elizabeth; Andrews, Elizabeth J; Martini, Alessandra C; Karch, Celeste M; Head, Elizabeth; Holtzman, David M; Zhang, Bin; Wang, Minghui; Maxfield, Frederick R; Poon, Wayne W; Goate, Alison M.

Cell; 185(13): 2213-2233.e25, 2022 06 23.

Artículo en Inglés | MEDLINE | ID: mdl-35750033

12.

Limb development genes underlie variation in human fingerprint patterns.

Li, Jinxi; Glover, James D; Zhang, Haiguo; Peng, Meifang; Tan, Jingze; Mallick, Chandana Basu; Hou, Dan; Yang, Yajun; Wu, Sijie; Liu, Yu; Peng, Qianqian; Zheng, Shijie C; Crosse, Edie I; Medvinsky, Alexander; Anderson, Richard A; Brown, Helen; Yuan, Ziyu; Zhou, Shen; Xu, Yanqing; Kemp, John P; Ho, Yvonne Y W; Loesch, Danuta Z; Wang, Lizhong; Li, Yingxiang; Tang, Senwei; Wu, Xiaoli; Walters, Robin G; Lin, Kuang; Meng, Ruogu; Lv, Jun; Chernus, Jonathan M; Neiswanger, Katherine; Feingold, Eleanor; Evans, David M; Medland, Sarah E; Martin, Nicholas G; Weinberg, Seth M; Marazita, Mary L; Chen, Gang; Chen, Zhengming; Zhou, Yong; Cheeseman, Michael; Wang, Lan; Jin, Li; Headon, Denis J; Wang, Sijia.

Cell; 185(1): 95-112.e18, 2022 01 06.

Artículo en Inglés | MEDLINE | ID: mdl-34995520

13.

Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8⁺ T cells in persons with previous COVID-19.

Ford, Emily S; Mayer-Blackwell, Koshlan; Jing, Lichen; Laing, Kerry J; Sholukh, Anton M; St Germain, Russell; Bossard, Emily L; Xie, Hong; Pulliam, Thomas H; Jani, Saumya; Selke, Stacy; Burrow, Carlissa J; McClurkan, Christopher L; Wald, Anna; Greninger, Alexander L; Holbrook, Michael R; Eaton, Brett; Eudy, Elizabeth; Murphy, Michael; Postnikova, Elena; Robins, Harlan S; Elyanow, Rebecca; Gittelman, Rachel M; Ecsedi, Matyas; Wilcox, Elise; Chapuis, Aude G; Fiore-Gartland, Andrew; Koelle, David M.

Nat Immunol; 25(1): 166-177, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-38057617

14.

Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.

Nygaard, Rie; Yu, Jia; Kim, Jonathan; Ross, Daniel R; Parisi, Giacomo; Clarke, Oliver B; Virshup, David M; Mancia, Filippo.

Cell; 184(1): 194-206.e14, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33357447

15.

A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization.

Cronan, Mark R; Hughes, Erika J; Brewer, W Jared; Viswanathan, Gopinath; Hunt, Emily G; Singh, Bindu; Mehra, Smriti; Oehlers, Stefan H; Gregory, Simon G; Kaushal, Deepak; Tobin, David M.

Cell; 184(7): 1757-1774.e14, 2021 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-33761328

16.

Molecular topography of an entire nervous system.

Taylor, Seth R; Santpere, Gabriel; Weinreb, Alexis; Barrett, Alec; Reilly, Molly B; Xu, Chuan; Varol, Erdem; Oikonomou, Panos; Glenwinkel, Lori; McWhirter, Rebecca; Poff, Abigail; Basavaraju, Manasa; Rafi, Ibnul; Yemini, Eviatar; Cook, Steven J; Abrams, Alexander; Vidal, Berta; Cros, Cyril; Tavazoie, Saeed; Sestan, Nenad; Hammarlund, Marc; Hobert, Oliver; Miller, David M.

Cell; 184(16): 4329-4347.e23, 2021 08 05.

Artículo en Inglés | MEDLINE | ID: mdl-34237253

17.

The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

Copin, Richard; Baum, Alina; Wloga, Elzbieta; Pascal, Kristen E; Giordano, Stephanie; Fulton, Benjamin O; Zhou, Anbo; Negron, Nicole; Lanza, Kathryn; Chan, Newton; Coppola, Angel; Chiu, Joyce; Ni, Min; Wei, Yi; Atwal, Gurinder S; Hernandez, Annabel Romero; Saotome, Kei; Zhou, Yi; Franklin, Matthew C; Hooper, Andrea T; McCarthy, Shane; Hamon, Sara; Hamilton, Jennifer D; Staples, Hilary M; Alfson, Kendra; Carrion, Ricardo; Ali, Shazia; Norton, Thomas; Somersan-Karakaya, Selin; Sivapalasingam, Sumathi; Herman, Gary A; Weinreich, David M; Lipsich, Leah; Stahl, Neil; Murphy, Andrew J; Yancopoulos, George D; Kyratsous, Christos A.

Cell; 184(15): 3949-3961.e11, 2021 07 22.

Artículo en Inglés | MEDLINE | ID: mdl-34161776

18.

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.

Béziat, Vivien; Rapaport, Franck; Hu, Jiafen; Titeux, Matthias; Bonnet des Claustres, Mathilde; Bourgey, Mathieu; Griffin, Heather; Bandet, Élise; Ma, Cindy S; Sherkat, Roya; Rokni-Zadeh, Hassan; Louis, David M; Changi-Ashtiani, Majid; Delmonte, Ottavia M; Fukushima, Toshiaki; Habib, Tanwir; Guennoun, Andrea; Khan, Taushif; Bender, Noemi; Rahman, Mahbuba; About, Frédégonde; Yang, Rui; Rao, Geetha; Rouzaud, Claire; Li, Jingwei; Shearer, Debra; Balogh, Karla; Al Ali, Fatima; Ata, Manar; Dabiri, Soroosh; Momenilandi, Mana; Nammour, Justine; Alyanakian, Marie-Alexandra; Leruez-Ville, Marianne; Guenat, David; Materna, Marie; Marcot, Léa; Vladikine, Natasha; Soret, Christine; Vahidnezhad, Hassan; Youssefian, Leila; Saeidian, Amir Hossein; Uitto, Jouni; Catherinot, Émilie; Navabi, Shadi Sadat; Zarhrate, Mohammed; Woodley, David T; Jeljeli, Mohamed; Abraham, Thomas; Belkaya, Serkan.

Cell; 184(14): 3812-3828.e30, 2021 07 08.

Artículo en Inglés | MEDLINE | ID: mdl-34214472

19.

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.

Brown, Alastair J H; Bradley, Sophie J; Marshall, Fiona H; Brown, Giles A; Bennett, Kirstie A; Brown, Jason; Cansfield, Julie E; Cross, David M; de Graaf, Chris; Hudson, Brian D; Dwomoh, Louis; Dias, João M; Errey, James C; Hurrell, Edward; Liptrot, Jan; Mattedi, Giulio; Molloy, Colin; Nathan, Pradeep J; Okrasa, Krzysztof; Osborne, Greg; Patel, Jayesh C; Pickworth, Mark; Robertson, Nathan; Shahabi, Shahram; Bundgaard, Christoffer; Phillips, Keith; Broad, Lisa M; Goonawardena, Anushka V; Morairty, Stephen R; Browning, Michael; Perini, Francesca; Dawson, Gerard R; Deakin, John F W; Smith, Robert T; Sexton, Patrick M; Warneck, Julie; Vinson, Mary; Tasker, Tim; Tehan, Benjamin G; Teobald, Barry; Christopoulos, Arthur; Langmead, Christopher J; Jazayeri, Ali; Cooke, Robert M; Rucktooa, Prakash; Congreve, Miles S; Weir, Malcolm; Tobin, Andrew B.

Cell; 184(24): 5886-5901.e22, 2021 11 24.

Artículo en Inglés | MEDLINE | ID: mdl-34822784

20.

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFß-mediated checkpoints.

Yin, Zhuoran; Rosenzweig, Neta; Kleemann, Kilian L; Zhang, Xiaoming; Brandão, Wesley; Margeta, Milica A; Schroeder, Caitlin; Sivanathan, Kisha N; Silveira, Sebastian; Gauthier, Christian; Mallah, Dania; Pitts, Kristen M; Durao, Ana; Herron, Shawn; Shorey, Hannah; Cheng, Yiran; Barry, Jen-Li; Krishnan, Rajesh K; Wakelin, Sam; Rhee, Jared; Yung, Anthony; Aronchik, Michael; Wang, Chao; Jain, Nimansha; Bao, Xin; Gerrits, Emma; Brouwer, Nieske; Deik, Amy; Tenen, Daniel G; Ikezu, Tsuneya; Santander, Nicolas G; McKinsey, Gabriel L; Baufeld, Caroline; Sheppard, Dean; Krasemann, Susanne; Nowarski, Roni; Eggen, Bart J L; Clish, Clary; Tanzi, Rudolph E; Madore, Charlotte; Arnold, Thomas D; Holtzman, David M; Butovsky, Oleg.

Nat Immunol; 24(11): 1839-1853, 2023 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-37749326

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