Evaluation of Hormonal Profile and Ovarian Morphology among Adolescent Girls with Menstrual Irregularities in a Tertiary Care Centre at Central India.

Menstrual disturbances are common among adolescents with a prevalence rate of 11.3-26.7%. The most frequent menstrual irregularities are oligomenorrhea, menorrhagia, polymenorrhoea, and hypomenorrhea. PCOS (polycystic ovarian syndrome) is now recognized as the most prevalent endocrine disorder among the women of reproductive age. The current study was planned to evaluate socio-demographic factors, endocrine profiles, and ovarian morphology among adolescent girls with menstrual irregularities and compare these parameters in different phenotypes of adolescent PCOS cases. It is a hospital-based cross-sectional study among 248 adolescent girls (10-19 years) with menstrual irregularities. After obtaining informed consent, history and clinical examination findings were recorded on preform proforma. All girls were assessed on day 2/3 of the menstrual cycle for hormonal profile (serum TSH, FSH, LH, prolactin, and serum testosterone) and ovarian morphology (by transabdominal ultrasonography). All participating girls were divided into three groups (groups 1, 2, and 3) corresponding to phenotypes A, B, & D as per the Rotterdam criteria. In the study, oligomenorrhea was the most common menstrual disorder (70.97%). Biochemical hyperandrogenism and thyroid dysfunction were reported in 14.91% and 8.46% of girls, respectively. Our study noted that phenotype D ,i.e., group 3 (MI + PCOM-HA; 49.43%) was the most common phenotype in the study. In a comparative analysis of different groups, significant differences (p < 0.05) in hormonal and metabolic parameters showed highest in group 2, which represents phenotype B of PCOS (hyperandrogenic anovulation). This analysis revealed that adolescent hyperandrogenism (phenotypes A and B) is associated with a more deranged hormonal and metabolic profile than nonandrogenic PCOS (phenotype D). To prevent long-term sequelae, lifestyle changes, early treatment, and close follow-up are recommended in this subset of girls.

A Community-based Study on Growth and Development of Under-Five Children in an Urbanized Village of South Delhi.

BACKGROUND: Optimal development of children in their early months and years has a bearing on their achievement levels later in life. OBJECTIVES: To assess the socio-emotional and cognitive development in children 0-5 years and to find out the proportion of children having developmental delay and its associated factors. METHODS: A community-based cross-sectional study was carried out in 520 children in Delhi. Development was assessed using the Indian Council for Medical Research Development Screening Test. RESULTS: In all, 10.6% of children <5 years old were found to be developmentally delayed. Maximum number of children (10.1%) were found to have a delay in the do main of 'hearing language, concept development'. Of all the factors, the strongest association was found with stunting, paternal education, alcohol abuse, attendance in anganwadi/playschool. CONCLUSIONS: The study concludes that developmental delay is present in a sizable proportion of children <5 years of age and may be a significant factor in the overall achievement of life's potential in them.

A Cross-Sectional Study on the Prevalence of Depression and Associated Factors in Tuberculosis Patients in the Vidisha District of Madhya Pradesh, India.

INTRODUCTION: Tuberculosis (TB) is a major public health problem in the developing world. Depression affects medicine adherence in TB patients. There is a scarcity of data regarding the prevalence of depression among TB patients from any city in central India. Therefore, the aim of this research was to study the prevalence of depression and associated factors in TB patients in the Vidisha district of Madhya Pradesh, India. METHODS: This was a cross-sectional study conducted on 106 TB patients visiting the TB and chest outpatient department of Atal Bihari Vajpayee Government Medical College (ABVGMC). It is a tertiary health care facility located in the district of Vidisha in Madhya Pradesh, India. Data collection was done from September 2020 to January 2021. Depression was measured using the Patient Health Questionnaire-9 (PHQ-9). We used a semi-structured questionnaire to collect data regarding relevant demographic and behavioral factors. Analyses were done in IBM SPSS software, version 25 (IBM Corp., Armonk, NY). RESULTS: The prevalence of depression among TB patients was 55.7% (n = 59). Depression in the mild category was most common (n = 44, 41.5%), followed by moderate (n = 10, 9.4%), and the moderately severe (n = 5, 4.7%) category. Depression prevalence was found to be slightly more common in females (58.5% vs. 52.8% in males), married participants (58.2% vs. 51.3% in unmarried), educated more than high school (56.8% vs. 54.8% in less than high school), socioeconomically Above Poverty Line (APL) (60.5% vs. 52.4% in Below Poverty Line (BPL)), living in urban areas (60.9% vs. 47.6% in rural areas), and in the continuation phase of anti-TB treatment (58.6% vs. 52.1% in intensive phase), but differences were statistically non-significant. Depression was significantly associated with the medicine non-adherence group (vs. the medicine adherence group; p-value: 0.022) and the previously treated TB patient category (vs. the new case group; p-value: 0.031). CONCLUSION: The prevalence of depression among TB patients was very high (55.7%). The prevalence of depression was significantly higher in the medicine non-adherent group (p-value: 0.022) and the previously treated TB patient group (p-value: 0.031). In this study, we have not found any significant association between the prevalence of depression among TB patients and sex, marital status, education attainment, poverty status, or living in an urban or rural areas.

Prevalence and Correlates of Depression Among School-Going Adolescents in the Urban Schools of Central India: A Cross-Sectional Study.

BACKGROUND: Adolescence is defined as the phase of development that occurs between childhood and adulthood. Presently in India, 243 million populations are staring at the crossroads of transition from childhood to adulthood. Physical, emotional, and social issues unique to this age group make them vulnerable to various mental problems. So, we conducted this study to quantify the current burden of depression in adolescents and its possible causes. MATERIALS AND METHODS: The present community-based cross-sectional study was conducted in the middle and late adolescent participants aged 14-19 years from 52 sections (clusters) of 9th to 12thclasses comprising a total of 1412 students with a multistage cluster sampling method. In total four sections (clusters), and one participant of class 9th, 10th, 11th, and 12th were chosen from 13 preselected schools. The questionnaire consisted of socio-demographic details, screen time, physical activity, etc., and the DASS-42 scale was used to determine the prevalence of depression.  Results: We found that the prevalence of depression in our study participants was around 39%. It was classified as 16.9%, 16.7%, 5.1%, and 0.5% participants respectively having mild, moderate, severe, and extremely severe depression. Mother's education was a statistically significant determinant for depression among these adolescents. CONCLUSION: The study concludes that the prevalence of depression (including mild, moderate, severe, or very severe) among school-going adolescents is 39%. We hereby recommend that a holistic approach should be followed involving parents and teachers with the help of school counselors to tackle and curb this problem.

Prevalence of Hypothyroidism in Pregnant Women in India: A Meta-Analysis of Observational Studies.

INTRODUCTION: This meta-analysis was conducted to estimate the prevalence of hypothyroidism among pregnant women in India. METHODS: We searched PubMed, Web of Science, Scopus, Google Scholar, and Shodhganga (Indian thesis repository) for observational studies, providing prevalence of hypothyroidism among pregnant women in India. Systematic study selection and data extraction procedures were followed. Quality assessment of each study was done using JBI critical appraisal checklist. The random effects model was used for pooling the effect sizes. Publication bias was assessed using the funnel plot and rank correlation test. I 2 statistics was used to measure heterogeneity across the studies. Heterogeneity in the pooled estimates was further explored with subgroup analyses and meta-regression analysis. RESULTS: Sixty-one studies were found eligible and included in this review. The pooled estimate of the prevalence of hypothyroidism in pregnant women was 11.07% (95% CI: 8.79-13.84, I 2 = 99%). Pooled prevalence estimates of subclinical and overt hypothyroidism are 9.51% (95% CI: 7.48-12.04, I 2 = 98%) and 2.74% (95% CI: 2.08-3.58, I 2 = 94%). CONCLUSION: We documented 11.07% pooled prevalence of hypothyroidism in pregnant women in India.

A meta-analysis on the prevalence of depression in perimenopausal and postmenopausal women in India.

INTRODUCTION: The mental health of perimenopausal and postmenopausal women is a relatively understudied area. This review formally explores the prevalence of depression in perimenopausal and postmenopausal women in India. METHODS: Databases like PubMed, Embase, Cochrane library, Web of Science and Scopus were systematically searched for cross-sectional or cohort studies, providing prevalence of depression in Indian perimenopausal and postmenopausal women. Systematic study selection and data extraction procedures were followed. Quality assessment of individual study was done using AXIS tool. For pooling of effect sizes, the random effects model was used. Funnel plot and Egger's test were used to ascertain publication bias. Subgroup analyses and meta-regression analysis were used to explore heterogeneity in the summary estimates. RESULTS: After a thorough search, ten studies were found to be eligible and included in this review. Pooled estimate for prevalence of depression (random effects model) in perimenopausal and postmenopausal women in India is 42.47 % (95 % CI: 28.73-57.49, I2 = 97.7 %). On visual inspection of the funnel plot and interpreting egger's test (bias: 3.49, SE bias: 3.68, p = 0.37), there was absence of publication bias. CONCLUSION: We documented 42.47 % pooled prevalence of depression in perimenopausal and postmenopausal women in India.

A hospital-based cross-sectional study on suicidal poisoning in Western Uttar Pradesh.

BACKGROUND AND AIMS: Poisoning is most common method of committing suicide in India. Objectives of this study to assess prevalence of suicidal poisoning among all poisoning cases, its socio-demographic profile and its reasons in all admitted cases of suicidal poisoning in hospital. METHODS: A cross-sectional study was conducted on cases of poisoning of any age group admitted in the Chhatrapati Shivaji Subharti Hospital, Meerut. Poisoning cases with history or evidence of suicide were further interviewed. A semi-structured interview schedule in Hindi was used to collect data. Microsoft Excel 365 and R software version 3.6.0 were used for data entry and analysis respectively. RESULTS: Among total 135 poisoning cases admitted in hospital, 126 provided consent and included in the study. Prevalence of suicidal poisoning was 77.7% (98). Most common age group involved was 11-20 years (36.7%) and 21-30 years (35.7%) and most of the participants were males (59.2%). Most suicidal poisoning cases took Aluminum Phosphide (31.6%), followed by Organophosphates (20.4%) as poison. Most frequent reasons for suicide as described by participants were 'Family quarrel or family unhappiness' (29.6%), 'failure in examination or interview or business' (23.5%), 'ill treatment by spouse or in laws' (16.3%) and 'unemployment' (9.2%). CONCLUSION: Our study shows that consuming Agriculture poisons (Aluminum Phosphide and Organophosphates) are most common (52%) poisons consumed by suicidal poisoning cases. Agriculture poisons (Aluminum Phosphide and Organophosphates) are easily available in markets in India. There should be some restriction on their purchase to reduce suicidal incidences.

Risk factors for undernutrition in under-five children living in a migrant populated area of South Delhi.

INTRODUCTION: Undernutrition is continuing to be a major public health problem in India. Moreover, India houses more than 30% of the world's stunted children aged under 5 years. There was a paucity of a community-based cross-sectional study on the nutrition of children aged under 5 years in urban Delhi. Therefore, we conducted this study to assess the prevalence of undernutrition and their associated factors in children aged under 5 years in urban South Delhi. MATERIALS AND METHODS: A cross-sectional community-based study was conducted in the Mehrauli area of South Delhi with a semi-structured questionnaire. Systematic random sampling without replacement was implemented. Informed written consent was sought from the parents of participants. Questions were asked regarding demography and sociocultural factors of the participants. Anthropometry measurements were obtained. Underweight and stunting were defined using WHO child growth standards 2006. RESULTS: A total of 520 participants in 695 houses were contacted and interviewed. Prevalence of underweight and stunting were 34.0% and 42.6%, respectively. Sociocultural factors, associated with underweight and stunting, found in current study were fathers' education (with both, P value < 0.05), mothers' education (with both, P value < 0.05), poverty status (with both, P value <0.05), overcrowding (stunting only, P value <0.05), fathers' alcohol abuse (with both, P value < 0.05) and exclusive breastfeeding for 6 months (stunting only, P value <0.05). RESULTS: A total of 520 participants in 695 houses were contacted and interviewed. Prevalence of underweight and stunting were 34.0% and 42.6%, respectively. Sociocultural factors, associated with underweight and stunting, found in current study were fathers' education (with both, P value < 0.05), mothers' education (with both, P value < 0.05), poverty status (with both, P value <0.05), overcrowding (stunting only, P value <0.05), fathers' alcohol abuse (with both, P value < 0.05) and exclusive breastfeeding for 6 months (stunting only, P value <0.05). CONCLUSIONS: There was a very high prevalence of underweight (34.0%) and stunting (42.6%) in children under 5 years age in Mehrauli.

Screening for common mental health problems and their determinants among school-going adolescent girls in Gujarat, India.

BACKGROUND: The school health program is a flagship program of Government of India with a focus on improving the physical and mental health of school children, but there is no specific strategy to screen for mental health disorders under the school health program. Also, the estimation of the prevalence of common mental disorders (CMDs) such as anxiety, depression, and psychosocial distress among school children is lacking. METHODS: The author conducted a cross-sectional study among 742 adolescent schoolgirls from one government, one government-aided, and one private school in an urban area in Gujarat. We used the pre-validated instrument, general health questionnaire-12 (GHQ-12) to screen for CMDs. We estimated adjusted odds of association between screening positive for CMDs and various determinants. RESULTS: 48.78% adolescent girls screened positive for CMDs which is alarming. Among sociodemographic characteristics, the type of school (adjusted odds of private is 1.8 and government 1.6), mother's higher education (3.0), father's less education (3.1), and working mother (1.5) had shown significant association with positive cases of the girls. Among psychosocial factors, abnormal sleep patterns (1.9) and disturbance in studies (2.3) have been found statistically significant for the presence of mental health problems among adolescent girls as per the GHQ score. CONCLUSION: CMDs such as anxiety, depression, and psychosocial distress were indeed very common among adolescent school-going girls in an urban area of Gujarat, India. There is an urgent need to focus attention on the mental health of adolescent girls.

Estimation of the prevalence of depression using diagnostic instruments in the elderly population in India, 2000-2019: a systematic review protocol.

INTRODUCTION: Depression is a common mental disorder in the elderly population, which significantly impacts their quality of life. However, correct estimates of its magnitude are not available in the elderly in India. The present systematic review and meta-analysis would attempt to estimate the prevalence of depression using diagnostic instruments among elderly persons aged 60 years and above. METHODS AND ANALYSIS: Searches will be performed in PubMed, Scopus, Embase, Web of Science, CINAHL and PsycINFO. Community-based cross-sectional and cohort studies (2001 to September 2019) reporting the prevalence of depression in the elderly, using diagnostic instruments will be included. Studies conducted among chronic disease patients, in-hospital patients and special groups such as with disaster-stricken populations, and studies reporting the only one or two subcategories of depression, will be excluded. Disagreements in study selection and data abstraction will be resolved by consensus and arbitration by a third reviewer. AXIS critical appraisal tool will be used for quality assessment of individual studies. Findings of eligible studies will be pooled using fixed-effects or random-effects meta-analysis whichever is appropriate. Heterogeneity between studies will be examined by Cochran's Q test and quantified by I² statistic. A cumulative meta-analysis will be used to detect temporal trends in the prevalence of depression and the effect of poor-quality studies on the pooled estimate. Publication bias will be assessed by visual inspection of funnel plots and the Egger test. ETHICS AND DISSEMINATION: No ethical approval will be needed because it will be a systematic review. Data from previously published studies will be retrieved and analysed. Findings will be disseminated through a peer-reviewed publication in a scientific journal and conferences. PROSPERO REGISTRATION NUMBER: CRD42019138453.