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1.
Eur Arch Otorhinolaryngol ; 277(4): 1177-1184, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31953634

RESUMEN

PURPOSE: It has been shown that the reflux of the gastric content to the proximal oesophagus influences incidence of voice prosthesis (VP) complications in laryngectomized patients. We conducted prospective randomised study to investigate the relationship between pepsin concentration in saliva and occurrence of VP complications before and after 3 months of proton pump inhibitor (PPI) therapy. METHODS: 60 laryngectomized patients with VP and 30 controls were included in the study. Saliva samples were collected in the morning and concentration of pepsin were measured by Human Pepsin (PG) ELISA kit. Thirty-Four (57%) patients reported one or more VP complication and were randomised in two groups, with and without PPI therapy, 40 mg pantoprazole per day for 3 months. RESULTS: Patients who had longer time since last VP change had higher incidence of periprosthetic and transprosthetic leakage and Candida colonisation. Pepsin was found in all saliva samples. Median saliva pepsin concentration level did not significantly differ between laryngectomized patients and control subjects, or between patients with and without VP complications, and there was no correlation between saliva pepsin concentration levels and type of VP complication. After 3 months therapy, there was no difference in median saliva pepsin level or incidence of VP complication between patients with and without PPI therapy. CONCLUSION: Although reflux was proposed to be associated with VP complications and pepsin was proven as a most sensitive and specific marker of EER, we did not find any statistically significant correlation between pepsin levels and occurrence of VP complications. A 3 months 40 mg pantoprazole therapy was ineffective in reduction of VP complications in our study group.


Asunto(s)
Laringe Artificial , Inhibidores de la Bomba de Protones , Humanos , Pepsina A , Estudios Prospectivos , Inhibidores de la Bomba de Protones/efectos adversos , Saliva
2.
Endocr J ; 64(2): 151-156, 2017 Feb 27.
Artículo en Inglés | MEDLINE | ID: mdl-27760899

RESUMEN

Parathyroid cysts (PCs) account for less than 1% of all parathyroid lesions and are most commonly located along thyroid lobes, rarely at ectopic sites. PCs are important because they can pose a differential diagnostic challenge against other cystic formations of the neck. PCs can be functional (elevated serum parathyroid hormone level) and nonfunctional. Four cases of nonfunctional PCs are presented. All four female patients underwent physical examination and ultrasonography of the neck with ultrasound-guided fine-needle aspiration biopsy (UG-FNA). The material thus obtained was stained by the standard May-Grünwald-Giemsa method. Parathyroid hormone level was determined in aspirate and serum, along with serum levels of total calcium, inorganic phosphates. In two asymptomatic patients, remission occurred after initial aspiration biopsy; one patient had compression syndrome with vocal cord paresis that required surgical treatment; and one patient had cyst recurrence that was surgically removed. Cystic neck masses can pose a major differential diagnostic problem considering different approach, treatment method, and preoperative and postoperative follow up. Surgical treatment is necessary in case of functional and large nonfunctional PCs (due to compression syndrome), whereas individualized therapeutic approach is used in case of small nonfunctional PCs. Ultrasonography with UG-FNA, cytologic analysis of the material obtained, and determination of parathyroid hormone level in aspirate and serum are crucial for making an accurate diagnosis.


Asunto(s)
Quistes , Enfermedades de las Paratiroides , Adulto , Anciano , Biopsia con Aguja Fina , Quistes/diagnóstico , Quistes/patología , Quistes/terapia , Diagnóstico Diferencial , Femenino , Humanos , Persona de Mediana Edad , Enfermedades de las Paratiroides/diagnóstico , Enfermedades de las Paratiroides/patología , Enfermedades de las Paratiroides/terapia , Glándulas Paratiroides/diagnóstico por imagen , Glándulas Paratiroides/patología , Estudios Retrospectivos , Glándula Tiroides/diagnóstico por imagen , Glándula Tiroides/patología , Ultrasonografía Intervencional/métodos
3.
Lijec Vjesn ; 138(5-6): 107-120, 2016 May.
Artículo en Croata | MEDLINE | ID: mdl-29182822

RESUMEN

Chronic kidney disease (CKD) is a systemic disease with numerous complications associated with increased morbidity and mortality. Chronic kidney disease-metabolic bone disease (CKD-MBD) starts at early stages of CKD with phosphorus accumulation and consequent initiation of numerous events that result with the development of secondary hyperparathyroidism with changes on bones and extraskeletal tissues. The most important and clinically most relevant consequences of CKD-MBD are vascular calcifications which contribute to cardiovascular mortality. Patients with the increased risk for the development of CKD-MBD should be recognized and treated. Prevention is the most important therapeutic option. The first step should be nutritional counseling with vitamin supplementation if necessary and correction of mineral status. Progression of CKD requires more intensive medicamentous treatment with the additional correction of metabolic acidosis and anemia. Renal replacement therapy should be timely initiated, with the adequate dose of dislaysis. Ideally, preemptive renal transplantion should be offered in individuals without contraindication for immunosuppressive therapy.


Asunto(s)
Enfermedades Óseas Metabólicas , Manejo de Atención al Paciente , Insuficiencia Renal Crónica , Enfermedades Óseas Metabólicas/diagnóstico , Enfermedades Óseas Metabólicas/etiología , Enfermedades Óseas Metabólicas/prevención & control , Enfermedades Óseas Metabólicas/terapia , Croacia , Progresión de la Enfermedad , Diagnóstico Precoz , Humanos , Monitoreo Fisiológico/métodos , Manejo de Atención al Paciente/métodos , Manejo de Atención al Paciente/organización & administración , Insuficiencia Renal Crónica/complicaciones , Insuficiencia Renal Crónica/diagnóstico , Insuficiencia Renal Crónica/terapia
4.
Eur Arch Otorhinolaryngol ; 270(1): 277-80, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22430034

RESUMEN

Necrotizing fasciitis (NF) is an unusual, life threatening, rapidly advancing infection characterized by widespread fascial and subcutaneous tissue necrosis and gangrene of the skin. It most commonly affects the extremities, abdominal wall and perineum, whereas cervical NF is rare. NF of the head and neck is often caused by both aerobic and anaerobic microorganisms found in the upper aerodigestive tract. Usually, cervical NF originates from odontogenic, tonsillar and pharyngeal infection, and it is very rarely a complication of surgical procedure. Without immediate surgical treatment, cervical NF leads to mediastinitis and fatal sepsis. There is only one case of cervical NF after total laryngectomy described in the literature. We report two cases of cervical NF after total laryngectomy, selective neck dissection and primary vocal prosthesis insertion. In both cases, the infection spreads to thoracic region and in one of them NF was associated with Lemierre's syndrome, i.e., thrombosis of the internal jugular vein. In both patients, vocal prosthesis was inserted during the infection and did not influence the healing process.


Asunto(s)
Fascitis Necrotizante/etiología , Laringectomía/efectos adversos , Cuello , Anciano , Biopsia , Terapia Combinada , Fascitis Necrotizante/microbiología , Fascitis Necrotizante/terapia , Humanos , Masculino , Persona de Mediana Edad
5.
Coll Antropol ; 36 Suppl 2: 47-51, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23397754

RESUMEN

Simple morphological identification of a sample as parathyroid gland tissue is not always sufficient for optimal patient treatment. Instead, patients with parathyroid gland lesions that increase the risk of disease relapse should be identified. To assess the possibility of differentiating adenoma from hyperplasia in preoperative material by use of computerized morphometric analysis in order to enable better preoperative work-up in patients with hyperparathyroidism. Samples obtained by US guided fine-needle aspiration biopsy of 67 parathyroid glands without known histopathologic diagnosis were dried and stained by May-Grünwald-Giemsa. Fifty nuclei per sample were analyzed and designated automatically with manual correction using image analyzer and specific software. The area, circumference, convexity, minimal and maximal radius, length and width, and factors of regularity, i.e. form factor and factor of nucleus elongation, were determined for each nucleus. Basic descriptive parameters and measures of variability (variation coefficient and standard deviation) were calculated for each continuous variable. The correlation of continuous variables was analyzed by use of Mann-Whitney test. Computer analysis of cell image classified the cell nuclei into two groups. The area, circumference, minimal radius, convexity and width of the nuclei showed higher values in the hyperplasia group as compared with the adenoma group. Standard deviation also showed higher values of each of the study parameters in the former group. Our own observations and subjective assessment of variations in nucleus size to represent substantial characteristics differentiating parathyroid adenoma and hyperplasia in cytologic smear were quantitatively verified by the use of objective morphometric measurement and should therefore be considered valid parameters on differentiating these two entities.


Asunto(s)
Adenoma/patología , Hiperplasia , Glándulas Paratiroides/patología , Diagnóstico Diferencial , Humanos
6.
Coll Antropol ; 36 Suppl 2: 93-7, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23397763

RESUMEN

The aim of this crossectional study was to investigate the relationship between pepsin concentration in saliva and the occurrence of tracheoesophageal fistula (TEF) complications and voice prosthesis (VP) complications, after total laryngectomy and VP implantation. We assessed the concentrations of pepsin in the saliva of 41 laryngectomized patients and correlated it with the incidence of TEF complications (periprostethic leakage, atrophy, esophageal mucosa hypertrophy, granulations, fistula enlargement, and VP dislocation), VP complications (transprosthetic leakage, Candida infection) and voice quality. Pepsin levels were measured by enzyme-linked immunoadsorbent assay (ELISA). Voice quality was assessed by Harrison-Robilard--Schultz (HRS) scale. In all, 17 (42%) patients had complications. All of them had TEF complications, whereas VP complication, together with TEF was found in 9 (22%) patients. We found no significant correlation between adjuvant radiotherapy and TEF complications. Most of patients, 30 (73%), had positive pepsin level in saliva. Median value of pepsin concentration in all patients was 4.8 (range 81.7). Median pepsin concentration was higher in patients free of TEF or VP complications (6.6, range 81.7 vs. 3.2, range 19.3) but that difference was not statistically significant (Mann-Whitney test, Z--1.562, p = 0.118). In addition, statistically insignificant negative correlation between pepsin levels and voice quality measured by HRS scale (Spearman's rho, p > 0.05). Although reflux was proposed as cause of TEF complications and pepsin has been proven as a most sensitive and specific marker of ekstraesophageal reflux, we did not find any statistically significant correlation between pepsin levels and occurrence of TEF or VP complications.


Asunto(s)
Laringe Artificial/efectos adversos , Pepsina A/metabolismo , Saliva/metabolismo , Fístula Traqueoesofágica/metabolismo , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad
7.
Coll Antropol ; 36 Suppl 2: 209-12, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23397789

RESUMEN

Primary cutaneus apocrine carcinoma is a rare malignancy with about 50 cases reported in the literature. Axilla is the most common site of occurrence, but locations like scalp, anogenital region, ear canal, chest, wrist, finger and eyelid have been described. The neoplasm presents itself as an asymptomatic, slow-growing, solid or cystic mass that varies in color. Most patients have a history of a long-standing neoplasm before the diagnosis is made. The disease is considered to have an indolent clinical course with favorable outcome although more than half of reported patients had regional lymph node metastases at the time of diagnosis. Systemic dissemination to lung, bones, liver and brain is extremely rare with only 14 cases documented in the literature. Wide surgical excision with lymph node dissection upon confirmation of the lymph node metastases remains the only curable treatment. Care and management of the disseminated disease is still challenging. We report a case of a 65-year-old woman with a very aggressive apocrine carcinoma of the scalp prone to local recurrence and distant metastases to lung and bones.


Asunto(s)
Glándulas Apocrinas/patología , Cuero Cabelludo/patología , Anciano , Glándulas Apocrinas/cirugía , Femenino , Humanos , Cuero Cabelludo/cirugía , Neoplasias Cutáneas/cirugía
8.
Coll Antropol ; 36 Suppl 2: 167-70, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23397779

RESUMEN

Angioleiomyoma is benign soft tissue tumor composed of smooth muscle cells and vascular endothelium, characterized with slow growth, unspecific symptoms and rare malignant transformation. It is very rare in the head and neck region and complete surgical excision is the gold standard for diagnosis and treatment. We present a very rare case of angoleomyoma of the tounge base treated with partial glosectomy with harmonic scalpel which shortened surgical procedure, reduced bleeding and postoperative complications.


Asunto(s)
Angiomioma/cirugía , Neoplasias de la Lengua/cirugía , Anciano , Humanos , Masculino , Complicaciones Posoperatorias , Procedimientos Quirúrgicos Operativos/efectos adversos
9.
Coll Antropol ; 33(3): 791-7, 2009 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19860105

RESUMEN

Acute respiratory failure due to chronic obstructive pulmonary disease (COPD) presents an increasing problem throughout the world. The aim of this study was to compare invasive and non-invasive mechanical ventilation (MV) for patients with COPD. A prospective, randomized trial was performed in a multidisciplinary intensive care unit for the period of 36 months and included 156 patients with COPD. MV procedure was performed using standard methods, and was applied as either invasive MV (IMV) or noninvasive MV (NIMV). Patients were randomized in two groups for application of MV using closed, nontransparent envelops. Comparison was made based on patient characteristics, objective parameters on admission and 1h, 4h, 24h, and 48h after admission and based on treatment outcome. We have confirmed that NIMV method is superior to IMV for patients with COPD. MV duration NIM:IMV was 94:172 hours, p < 0.001, time spent in Intensive Care Unit 120:223 hours, p < 0.001. Ventilator associated pneumonia 5(6%):29(37%), p < 0.001. The advantage of NIMV in COPD patients, especially in the early stages was confirmed.


Asunto(s)
Enfermedad Pulmonar Obstructiva Crónica/terapia , Respiración Artificial/métodos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Unidades de Cuidados Intensivos , Masculino , Persona de Mediana Edad , Estudios Prospectivos
10.
Coll Antropol ; 32(2): 375-80, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18756884

RESUMEN

Aim of the study was to determine the potential of Duke Treadmill Score (DTS) in prioritizing patients for coronary angiography in a transitional country clinical setting. We analyzed 114patients with suspected stable coronary artery disease who underwent exercise treadmill testing, and coronary angiography in Slavonski Brod General Hospital. DTS was calculated from treadmill test as: exercise time--(5 x ST deviation in mm)--(4 x exercise angina). Regarding the score, patients were grouped into three groups of risk for coronary artery disease: low risk, medium risk, and high risk patients. All patients underwent coronary angiography, and were grouped in accordance to the severity of the coronary artery disease into three groups: insignificant, significant, or severe coronary artery disease. All patients scored as high risk DTS had significant or severe coronary artery disease. Medium and low risk DTS patients had insignificant coronary artery disease in 50%, and 90% of cases, respectively. Medium risk patients with significant or severe coronary artery disease were significantly older, and had more frequent history of typical chest pain with higher number of episodes per week (P<0.05), whereas there were no differences regarding gender or presence of risk factors. There were no significant differences among medium risk patients regarding the severity of coronary artery disease in exercise time or ST deviation. However, the presence of limiting exercise angina in medium risk patients was significantly more related with significant and severe coronary artery disease (P<0.05). High risk DTS result showed great potential in stratifying patients for immediate coronary angiography. This scoring system may be used in prioritizing patients for coronary angiography in a transitional clinical setting.


Asunto(s)
Angiografía Coronaria , Enfermedad de la Arteria Coronaria/diagnóstico , Prueba de Esfuerzo , Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Electrocardiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo
11.
Med Glas (Zenica) ; 15(1): 52-58, 2018 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-29549690

RESUMEN

Aim Distal metastases to oral cavity are very rare. Adenocarcinoma, renal cell carcinoma (RCC) and squamous cell carcinoma are the most common metastatic tumours. The aim of this study was to assess the diagnostic relevance of metastatic renal cell carcinoma on tongue manifestations in large patient series. Methods A patient with distal RCC metastases to the tongue and neck lymph nodes as the first manifestations of malignancy was presented. Also, all reports described during 106-year period relating to distal RCC metastasis to the tongue were evaluated. Results In the presented patient, initial presentation of RCC was metastasis to the tongue. Three months after nephrectomy, tongue tumour resection and radical neck dissection were performed. Histopathological analysis confirmed RCC metastasis. Postoperatively, the patient underwent radiotherapy and polychemotherapy. Tongue metastasis from RCC is extremely rare with only 51 cases reported during the 106-year period. In only 7 patients tongue metastasis was reported as an initial presentation of RCC. Conclusion The RCC metastasizing to the tongue is extremely rare and thus it poses a diagnostic challenge especially when it is the first sign of malignancy. Therapeutic decisions should maximize patient comfort and minimize morbidity considering the poor long-term prognosis.


Asunto(s)
Carcinoma de Células Renales/patología , Riñón/patología , Neoplasias de la Lengua/diagnóstico , Lengua/patología , Anciano , Anciano de 80 o más Años , Carcinoma de Células Renales/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Primarias Desconocidas , Neoplasias de la Lengua/secundario , Neoplasias de la Lengua/terapia
12.
Croat Med J ; 48(1): 51-8, 2007 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17309139

RESUMEN

AIM: To compare T-tube and pressure support ventilation (PSV) as two methods of mechanical ventilation weaning of patients with chronic obstructive pulmonary disease (COPD) after failed extubation. METHODS: A prospective randomized trial carried out at the multidisciplinary intensive care unit (ICU) over 2 years included 136 patients with COPD who required mechanical ventilation longer than 24 hours. The patients who could be weaned from mechanical ventilation were randomized to either a T-tube or PSV 2-hour spontaneous breathing trial. The patients in whom 2-hour trial was successful were extubated and excluded from further research. Patients in whom 2-hour trial failed had mechanical ventilation reinstated and underwent the same weaning procedure after 24 hours in case they fulfilled the weaning criteria. The weaning outcome was assessed according to the following parameters: extubation success, mechanical ventilation duration, time spent in ICU, reintubation rate, and mortality rate. RESULTS: Two-hour trial failed in 31 patients in T-tube and 32 patients in PSV group, of whom 17 and 23, respectively, were successfully extubated (P<0.001, chi(2)test). Mechanical ventilation lasted significantly longer in T-tube than in PSV group (187 hours vs 163 hours, respectively, P<0.001, Mann-Whitney test). Also, patients in T-tube group spent significantly more time in ICU than patients in PVS group (241 hours [interquartile range 211-268] vs 210 hours [211-268], respectively, P<0.001, Mann-Whitney test). Reintubation was required in 8 and 6 patients in T-tube and PVS group, respectively, and death occurred in 4 and 2 patients, respectively, during ICU stay. CONCLUSION: Patients with COPD who failed the 2-hour spontaneous breathing trial had more favorable outcome when PVS rather than T-tube method was used for weaning from mechanical ventilation.


Asunto(s)
Intubación Intratraqueal/instrumentación , Respiración con Presión Positiva/métodos , Enfermedad Pulmonar Obstructiva Crónica/diagnóstico , Enfermedad Pulmonar Obstructiva Crónica/terapia , Desconexión del Ventilador/métodos , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Unidades de Cuidados Intensivos , Masculino , Persona de Mediana Edad , Respiración con Presión Positiva/instrumentación , Probabilidad , Estudios Prospectivos , Respiración , Respiración Artificial/efectos adversos , Respiración Artificial/métodos , Pruebas de Función Respiratoria , Factores de Riesgo , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Factores de Tiempo , Resultado del Tratamiento
13.
Coll Antropol ; 31(3): 829-36, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-18041396

RESUMEN

Our aim was to evaluate the influence of static pulmonary compliance (Cst) on the choice of Mechanical Ventilation(MV) method and treatment outcome. A prospective, randomized trial conducted out at the multidisciplinary Intensive Care Unit (ICU) included 387 patients, randomized in two groups: noninvasive MV group and invasive MV group. Furthermore, each group was divided in two groups: Cst < or = 0.025 and Cst > 0.025 L/cm H2O. In patients with Cst > 0.025 L/cm H2O MV duration, noninvasive vs invasive, was 92 vs 114 h, p = 0.039, time spent in ICU 118 vs 164 h, p = 0.004. In patients with Cst < or = 0.025, MV duration was 141 vs 189 h, p < 0.001, time spent in ICU 190 vs 246 h, p = 0.001, all patients were intubated. Need for tracheostomy was 6 (11%) vs 39 (46%) patients, p = 0.005, and ICU mortality was 15 (26%) vs 21 (25%) patients. Statistical significance in favor of noninvasive method was confirmed in patients with Cst > 0.025 L/cm H2O in MV duration, time spent in ICU, need for tracheostomy and intubation rate. In the group with Cst < or = 0.025 no significant difference in treatment failure was recorded between the two MV methods.


Asunto(s)
Oxígeno/metabolismo , Respiración Artificial/métodos , Mecánica Respiratoria , Adulto , Anciano , Croacia , Femenino , Mortalidad Hospitalaria , Humanos , Intubación Intratraqueal , Masculino , Persona de Mediana Edad , Presión Parcial , Estudios Prospectivos , Respiración Artificial/efectos adversos , Traqueostomía , Resultado del Tratamiento
14.
Acta Clin Croat ; 56(3): 425-436, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-29479908

RESUMEN

Lyme borreliosis is a vector-borne infectious disease characterized by three disease stages. In the areas endemic for borreliosis, every acute facial palsy indicates serologic testing and implies specific approach to the disease. Th e aim of the study was to identify and confirm the value of acoustic refl ex and House-Brackman (HB) grading scale as prognostic indicators of facial palsy in neuroborreliosis. Th e study included 176 patients with acute facial palsy divided into three groups based on serologic testing: borreliosis, Bell's palsy, and facial palsy caused by herpes simplex virus type 1 (HSV-1). Study patients underwent baseline audiometry with tympanometry and acoustic reflex, whereas current state of facial palsy was assessed by the HB scale. Subsequently, the same tests were obtained on three occasions, i.e. in week 3, 6 and 12 of presentation. Th e patients diagnosed with borreliosis, Bell's palsy and HSV-1 differed according to the time to acoustic refl ex recovery, which took longest time in patients with borreliosis. Th ese patients had the highest percentage of suprastapedial lesions at all time points and recovery was achieved later as compared with the other two diagnoses. Th e mean score on the HB scale declined with time, also at a slower rate in borreliosis patients. Th e prognosis of acoustic refl ex and facial palsy recovery according to HB scale was not associated with the length of elapsed time. The results obtained in the present study strongly confirmed the role of acoustic reflex and HB grading scale as prognostic indicators of facial palsy in neuroborreliosis.


Asunto(s)
Parálisis de Bell , Parálisis Facial , Herpesvirus Humano 1 , Neuroborreliosis de Lyme , Reflejo Acústico , Adulto , Parálisis de Bell/diagnóstico , Parálisis de Bell/etiología , Parálisis de Bell/virología , Parálisis Facial/diagnóstico , Parálisis Facial/etiología , Parálisis Facial/fisiopatología , Parálisis Facial/virología , Femenino , Herpesvirus Humano 1/aislamiento & purificación , Herpesvirus Humano 1/patogenicidad , Humanos , Neuroborreliosis de Lyme/complicaciones , Neuroborreliosis de Lyme/diagnóstico , Neuroborreliosis de Lyme/fisiopatología , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Pronóstico
15.
Life Sci ; 173: 73-79, 2017 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-28185819

RESUMEN

AIMS: Expression of polySia is associated with metastatic dissemination and progression of various malignant diseases. In particular, it may contribute to tumorigenesis by a negative modulatory effect on cellular signaling cascades responsible for cellular migration, differentiation and proliferation. In this study, we investigated the expression of polySia in primary metastatic and non-metastatic laryngeal squamous cell carcinoma (LSCC) tumor tissues and its potential impact on the LSCC progression. MAIN METHODS: The expression of polySia in metastatic and non-metastatic primary laryngeal squamous cell carcinoma (LSCC) tumor biopsy specimens was investigated by immunohistochemistry, while the expression of polysialyltransferase IV (ST8SiaIV)(), fibroblast growth factor receptor 1 (FGFR1), extracellular signal regulated kinases 1 and 2 (Erk 1/2) and c-Raf was tested in metastatic and non-metastatic primary tumor tissues (including the corresponding non-tumor control tissues) by Western blot analysis. KEY FINDINGS: The expression of polySia was detected in LSCC biopsies specimens with generally stronger immunoreactivity in non-metastatic tumor LSCC sections and in histologically undifferentiated tumors. Also, increased polySia expression was observed in adjacent histologically unaltered laryngeal tumor-associated tissue of the metastatic sections. In addition, we provide an evidence of increased polysialyltransferase IV (ST8SiaIV) expression, involved in polySia synthesis in both metastatic and non-metastatic primary tumors which is accompanied by decreased levels of FGFR1, Erk 1/2 and c-Raf. SIGNIFICANCE: We present for the first time the evidence for the polySia expression in LSCC biopsies specimens which suggests its potential impact on initial steps of LSCC malignant transformation.


Asunto(s)
Carcinoma de Células Escamosas/metabolismo , Regulación Neoplásica de la Expresión Génica , Neoplasias Laríngeas/metabolismo , Ácidos Siálicos/biosíntesis , Anciano , Carcinoma de Células Escamosas/patología , Humanos , Neoplasias Laríngeas/patología , Masculino , Persona de Mediana Edad , Metástasis de la Neoplasia , Proteínas de Neoplasias/biosíntesis , Sialiltransferasas/biosíntesis , Células Tumorales Cultivadas
16.
Acta Med Croatica ; 60(4): 365-8, 2006 Sep.
Artículo en Croata | MEDLINE | ID: mdl-17048791

RESUMEN

INTRODUCTION: There are many diagnostic and therapeutic dilemmas as well as variations in the treatment of neck trauma. AIM: Our own experiences offer a protocol of treatment for neck trauma. PATIENTS AND METHODS: During the 1991-2003 period, 139 patients with neck trauma were treated at Dr. Josip Bencevic General Hospital in Slavonski Brod, 95 with war injuries and 44 with peacetime injuries. RESULTS: Immediate neck exploration was done in 115 patients, and 62 (54%) followed-up based on diagnostic procedure was positive without surgical treatment. DISCUSSION: Currently, there are two approaches in the treatment of neck trauma: exploration of neck injuries deeper than platysma, and selective approach when neck exploration is done depending on clinical status and diagnosis. CONCLUSION: The authors emphasize immediate exploration of penetrating neck injuries as decisive in surgical treatment, irrespective of peacetime or war trauma. Neck injuries should be treated by the principles of definitive treatment.


Asunto(s)
Traumatismos del Cuello , Guerra , Croacia , Humanos , Personal Militar , Traumatismos del Cuello/diagnóstico , Traumatismos del Cuello/patología , Traumatismos del Cuello/terapia
17.
Acta Med Croatica ; 60(4): 319-23, 2006 Sep.
Artículo en Croata | MEDLINE | ID: mdl-17048784

RESUMEN

UNLABELLED: Laryngotracheal stenosis, although not very common, is an important medical condition that represents a true diagnostic and therapeutic challenge. We present our experiences in treating 22 patients with laryngotracheal stenosis between 1995 and 2004 at Department of ENT, Head and Neck Surgery, Dr. Josip Bencevic General Hospital in Slavonski Brod. PATIENTS AND METHODS: Stenosis was caused by trauma in 9 patients, by endotrauma due to intubation in 3, and by war penetrating injury caused by shell and mine fragments in 4 patients. Hypertrophic glottic stenosis, after supraglottic laryngectomy and postoperative radiotherapy caused laryngeal obstruction in 2 patients. Tumors caused stenosis in 11 patients: tumors of the thyroid with compression in 9, and malignant infiltration of the trachea in 2 patients. Glottic stenosis was present in 4, glottic and subglottic in 4, subglottic and tracheal in 2, isolated tracheal stenosis in 12 patients. Surgical treatment was performed in 14 patients: endoscopic in two and classic open procedure in 12 patients. Laryngeal and tracheal stents were inserted in 3 patients with inopeable thyroid tumor. All treated patients except one were extubated. RESULTS: Excellent functional results were achieved upon endoscopic resection, resection of stenosis and end-to-end anastomosis. Minimally invasive and good palliative treatment was achieved by the stent placement into the airway.


Asunto(s)
Laringoestenosis/etiología , Estenosis Traqueal/etiología , Adulto , Niño , Femenino , Humanos , Laringoestenosis/cirugía , Masculino , Estenosis Traqueal/cirugía
18.
Acta Dermatovenerol Croat ; 11(3): 153-7, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-12967507

RESUMEN

Cutaneous metastases from carcinoma are relatively uncommon in clinical practice. Metastasis to skin sites from squamous cell carcinoma of the mucosa of the head and neck are also very rare. However, skin metastases may be the first clinical evidence of the malignant disease or its loco-regional recurrence. Early recognition of skin metastasis can lead to an accurate and prompt diagnosis and timely treatment. Patients with skin metastases have very poor prognosis. We report on four such patients, one of them with multiple skin metastases from the squamous cell carcinoma in the cervical part of the esophagus above and below the level of the diaphragm. In reviewing the literature, only two cases of solitary skin metastases below the diaphragm from laryngeal squamous cell carcinomas have been reported


Asunto(s)
Carcinoma de Células Escamosas/secundario , Neoplasias de Cabeza y Cuello/patología , Neoplasias Cutáneas/secundario , Carcinoma de Células Escamosas/patología , Femenino , Humanos , Pierna/patología , Masculino , Persona de Mediana Edad , Nariz/patología , Neoplasias Cutáneas/patología , Tórax/patología
19.
Wien Klin Wochenschr ; 125(17-18): 524-8, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23934185

RESUMEN

BACKGROUND AND OBJECTIVES: Tonsillectomy is a very painful procedure. Pain may be severe, and patients are often unable to perform in school or eat regular food for a number of days after the surgery. The aim of this study was to compare the quality of life after undergoing two different surgical techniques of tonsillectomy, harmonic scalpel and classic tonsillectomy with bipolar cauterization. DESIGN AND SETTING: Prospective randomized double-blind, clinical trial study conducted in the ENT Department, Dr. Josip Bencevic General Hospital, Slavonski Brod, Croatia. PATIENTS AND METHODS: Data were collected, according to the type of operation, on pain persistence and intensity and returning to normal eating with tonsillectomy patients during the first seven postoperative days. Group A consisted of 50 children submitted to classic tonsillectomy with bipolar cauterization, while group B included 50 children operated on using the harmonic scalpel. Data on pain intensity were obtained using pain measuring scales adjusted to children's age (Faces scales, visual analog scale). The first day of normal oral food intake was recorded. RESULTS: The analysis of variance revealed that the grade of pain significantly differs by a surgical technique employed, and that it significantly varied over the first seven postoperative days. The pain was more severe after undergoing the harmonic scalpel technique and children started to eat later compared with the classic tonsillectomy. CONCLUSION: The classic tonsillectomy method with bipolar cauterization is the method of choice due to lower postoperative pain levels and sooner normal eating. The quality of life is better after undergoing the classic tonsillectomy method.


Asunto(s)
Trastornos de Alimentación y de la Ingestión de Alimentos/epidemiología , Dolor Postoperatorio/epidemiología , Calidad de Vida , Tonsilectomía/métodos , Tonsilitis/epidemiología , Tonsilitis/cirugía , Adolescente , Causalidad , Niño , Comorbilidad , Croacia/epidemiología , Método Doble Ciego , Trastornos de Alimentación y de la Ingestión de Alimentos/prevención & control , Femenino , Humanos , Masculino , Dimensión del Dolor/estadística & datos numéricos , Dolor Postoperatorio/diagnóstico , Dolor Postoperatorio/prevención & control , Satisfacción del Paciente , Prevalencia , Estudios Prospectivos , Factores de Riesgo , Resultado del Tratamiento
20.
Med Glas (Zenica) ; 9(2): 438-41, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22926398

RESUMEN

The success of a frontal sinus endoscopic or external operation depends on the postoperative stenosis of the frontal sinus ostium. Formation of a stenosis can be prevented by placing a stent in the frontal sinus ostium. The period optimal for leaving the stent in the sinus ostium is yet to be established, but experts recommend a maximum six months period. This case report presents a female patient who underwent an endoscopic bilateral frontal sinus operation in 2005. Postoperatively, she developed a stenosis of the right frontal sinus recess which resulted in a series of reoperations. At the end of 2009, a Medtronix Xomed Incl Parell T-Frontal Stent was inserted by external approach. At the 21-month followup, the patient was still free from discomfort with the stent normally placed. Proper hygiene, regular monitoring and endoscopic cleansing of the patient's stent resulted in the sinus orderly functioning with the stent placed within its ostium, without incrustation or breathing difficulties and headaches as a consequence.


Asunto(s)
Seno Frontal , Sinusitis Frontal/cirugía , Complicaciones Posoperatorias/terapia , Stents , Adulto , Constricción Patológica/etiología , Constricción Patológica/terapia , Femenino , Seno Frontal/cirugía , Humanos
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