Detalles de la búsqueda
1.
A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1.
Int J Mol Sci;
24(23)2023 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38068959
2.
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Proc Natl Acad Sci U S A;
112(15): 4666-71, 2015 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25825768
3.
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.
J Biol Chem;
291(18): 9482-91, 2016 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26940874
4.
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.
J Biol Chem;
291(18): 9492-500, 2016 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26940875
5.
Improved molecular replacement by density- and energy-guided protein structure optimization.
Nature;
473(7348): 540-3, 2011 May 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-21532589
6.
The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
Proc Natl Acad Sci U S A;
111(42): 15054-9, 2014 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25288771
7.
Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.
J Struct Biol;
192(3): 342-348, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26416531
8.
Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis.
BMC Bioinformatics;
15: 75, 2014 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24646163
9.
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.
J Biol Chem;
288(23): 16789-16799, 2013 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23572527
10.
Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family.
Proteins;
82(6): 1086-92, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24174223
11.
Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.
J Bacteriol;
195(24): 5555-66, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24123814
12.
Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila.
BMC Bioinformatics;
14: 265, 2013 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24004689
13.
Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum.
Acta Crystallogr D Biol Crystallogr;
68(Pt 4): 391-403, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22505259
14.
Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH).
Front Oncol;
11: 778925, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34900730
15.
Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.
Prog Biophys Mol Biol;
163: 130-142, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33115610
16.
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes.
J Biol Chem;
284(37): 25268-79, 2009 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-19567872
17.
The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.
Acta Crystallogr Sect F Struct Biol Cryst Commun;
66(Pt 10): 1174-81, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20944208
18.
Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism.
Acta Crystallogr Sect F Struct Biol Cryst Commun;
66(Pt 10): 1182-9, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20944209
19.
The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45â Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator.
Acta Crystallogr Sect F Struct Biol Cryst Commun;
66(Pt 10): 1198-204, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20944211
20.
Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction.
Acta Crystallogr Sect F Struct Biol Cryst Commun;
66(Pt 10): 1218-25, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20944214