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1.
Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.
Cancer Cell;
8(1): 49-59, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16023598
2.
Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses.
Mol Ther;
19(3): 567-75, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21179008
3.
Noninvasive imaging of lipid nanoparticle-mediated systemic delivery of small-interfering RNA to the liver.
Mol Ther;
18(9): 1657-66, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20628357
4.
Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.
Mol Ther;
18(1): 171-80, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19738601
5.
An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.
Mol Cell Biol;
27(2): 689-98, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17101792
6.
Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.
Mol Cancer Ther;
1(9): 747-58, 2002 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12479371
7.
A cell-based radioligand binding assay for farnesyl: protein transferase inhibitors.
J Biomol Screen;
8(4): 430-8, 2003 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-14567795
8.
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
J Med Chem;
51(14): 4239-52, 2008 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-18578472
9.
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett;
17(19): 5390-5, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17761419
10.
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett;
17(20): 5677-82, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17766111
11.
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett;
17(20): 5671-6, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17804233
12.
Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorg Med Chem Lett;
12(9): 1269-73, 2002 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-11965368
13.
Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorg Med Chem Lett;
14(3): 639-43, 2004 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-14741259
14.
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Bioorg Med Chem Lett;
12(15): 2027-30, 2002 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12113834
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