RESUMEN
This study assessed the comparative efficacy of lisocabtagene maraleucel (liso-cel) in PILOT (NCT03483103), an open-label, phase II study, versus conventional second-line (2L) chemotherapy regimens in the real world administered to patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) who were not intended for hematopoietic stem cell transplantation (HSCT). The liso-cel-treated cohort (n=61) was based on patients who received liso-cel in the PILOT study. The conventional chemotherapy cohort included patients who met PILOT eligibility criteria and received conventional 2L chemotherapy in the real-world clinical setting (n=273). After using the trimmed stabilized inverse probability of treatment weighting method to balance cohorts according to baseline characteristics, there were statistically significant differences in all tested measures of efficacy. Compared with real-world conventional chemotherapy regimens, liso-cel demonstrated higher overall response rates (79.6% with liso-cel vs. 50.5% with conventional chemotherapy; relative risk [RR], 1.6; P.
RESUMEN
The Congo Basin, being one of the major basins in the tropics, is important to the global climate, yet its hydrology is perhaps the least understood. Although various reanalysis/analysis datasets have been used to improve our understanding of the basin's hydroclimate, they have been historically difficult to validate due to sparse in situ measurements. This study analyzes the impact of model resolution on the spatial variability of the Basin's hydroclimate using the Decorrelation Length Scale (DLCS) technique, as it is not subject to uniform model bias. The spatial variability within the precipitation (P), evaporation/evapotranspiration (E), and precipitation-minus-evaporation (P-E) fields were investigated across four spatial resolutions using reanalysis/analysis datasets from the ECMWF ranging from 9-75 km. Results show that the representation of P and P-E fields over the Basin and the equatorial Atlantic Ocean are sensitive to model resolution, as the spatial patterns of their DCLS results are resolution-dependent. However, the resolution-independent features are predominantly found in the E field. Furthermore, the P field is the dominant source of spatial variability of P-E, occurring over the land and the equatorial Atlantic Ocean, while over the Southern Atlantic, P-E is mainly governed by the E field, with both showing weak spatial variability.
RESUMEN
This study used a real-world population as a synthetic comparator for the single-arm TRANSCEND NHL 001 study (TRANSCEND; NCT02631044) to evaluate the efficacy of lisocabtagene maraleucel (liso-cel) compared with conventional (noncellular) therapies in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Inclusion and exclusion criteria for the real-world study closely matched the enrollment criteria in TRANSCEND. The analytic comparator cohort was created by matching and balancing observed baseline characteristics of real-world patients with those in TRANSCEND using propensity score methodology. Efficacy outcomes comparing liso-cel- (n = 257) and conventional therapy-treated (n = 257) patients, respectively, significantly favored liso-cel: overall response rate (74% vs 39%; p < 0.0001), complete response rate (50% vs 24%; p < 0.0001), median overall survival (23.5 vs 6.8 months; p < 0.0001), and median progression-free survival (3.5 vs 2.2 months; p < 0.0001). These results demonstrated a statistically significant and clinically meaningful benefit of liso-cel in patients with third- or later-line R/R LBCL relative to conventional therapies.Clinical trial registration: ClinicalTrials.gov identifier: NCT02631044.