Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?

OBJECTIVE: To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy. METHODS: Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system. RESULTS: PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis. CONCLUSION: PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment.