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1.

Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction.

Bergeron, John J M; Di Guglielmo, Gianni M; Dahan, Sophie; Dominguez, Michel; Posner, Barry I.

Annu Rev Biochem; 85: 573-97, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27023845

2.

Molecular mechanisms of mammalian autophagy.

Trelford, Charles B; Di Guglielmo, Gianni M.

Biochem J; 478(18): 3395-3421, 2021 09 30.

Artículo en Inglés | MEDLINE | ID: mdl-34554214

3.

Synthetic triterpenoids inhibit GSK3ß activity and localization and affect focal adhesions and cell migration.

To, Ciric; Roy, Ashbeel; Chan, Eddie; Prado, Marco A M; Di Guglielmo, Gianni M.

Biochim Biophys Acta Mol Cell Res; 1864(7): 1274-1284, 2017 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-28366661

4.

Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.

Beraldo, Flavio H; Ostapchenko, Valeriy G; Xu, Jason Z; Di Guglielmo, Gianni M; Fan, Jue; Nicholls, Peter J; Caron, Marc G; Prado, Vania F; Prado, Marco A M.

J Neurochem; 145(1): 68-79, 2018 04.

Artículo en Inglés | MEDLINE | ID: mdl-29265373

5.

The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells.

Chan, Eddie; Saito, Akira; Honda, Tadashi; Di Guglielmo, Gianni M.

Biochim Biophys Acta; 1863(4): 638-49, 2016 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-26775215

6.

aPKC alters the TGFß response in NSCLC cells through both Smad-dependent and Smad-independent pathways.

Gunaratne, Adrian; Chan, Eddie; El-Chabib, Tarek H; Carter, David; Di Guglielmo, Gianni M.

J Cell Sci; 128(3): 48798, 2015 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-25501807

7.

Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration.

Chan, Eddie; Dirk, Brennan S; Honda, Tadashi; Stathopulos, Peter B; Dikeakos, Jimmy D; Di Guglielmo, Gianni M.

Biochim Biophys Acta Mol Cell Res; 1871(2): 119629, 2024 02.

Artículo en Inglés | MEDLINE | ID: mdl-37981034

8.

Expanding the Chemical Space of Transforming Growth Factor-ß (TGFß) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives.

Längle, Daniel; Wojtowicz-Piotrowski, Stephanie; Priegann, Till; Keller, Niklas; Wesseler, Fabian; Reckzeh, Elena S; Steffens, Karsten; Grathwol, Christoph; Lemke, Jana; Flasshoff, Maren; Näther, Christian; Jonson, Anna C; Link, Andreas; Koch, Oliver; Di Guglielmo, Gianni M; Schade, Dennis.

ACS Pharmacol Transl Sci; 7(4): 1069-1085, 2024 Apr 12.

Artículo en Inglés | MEDLINE | ID: mdl-38633593

9.

Autophagy regulates transforming growth factor ß signaling and receptor trafficking.

Trelford, Charles B; Di Guglielmo, Gianni M.

Biochim Biophys Acta Mol Cell Res; 1869(9): 119284, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35605790

10.

Transforming growth factor-ß in tumour development.

Trelford, Charles B; Dagnino, Lina; Di Guglielmo, Gianni M.

Front Mol Biosci; 9: 991612, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-36267157

11.

Prolonged proteasome inhibition antagonizes TGFß1-dependent signalling by promoting the lysosomal-targeting of TGFß receptors.

Trelford, Charles B; Di Guglielmo, Gianni M.

Cell Signal; 98: 110414, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-35901932

12.

Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.

To, Ciric; Shilton, Brian H; Di Guglielmo, Gianni M.

J Biol Chem; 285(36): 27944-57, 2010 Sep 03.

Artículo en Inglés | MEDLINE | ID: mdl-20566646

13.

Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.

Di Guglielmo, Gianni M; Le Roy, Christine; Goodfellow, Anne F; Wrana, Jeffrey L.

Nat Cell Biol; 5(5): 410-21, 2003 May.

Artículo en Inglés | MEDLINE | ID: mdl-12717440

14.

TGF beta (transforming growth factor beta) receptor type III directs clathrin-mediated endocytosis of TGF beta receptor types I and II.

McLean, Sarah; Di Guglielmo, Gianni M.

Biochem J; 429(1): 137-45, 2010 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-20406198

15.

Canonical and Non-canonical TGFß Signaling Activate Autophagy in an ULK1-Dependent Manner.

Trelford, Charles B; Di Guglielmo, Gianni M.

Front Cell Dev Biol; 9: 712124, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34760883

16.

p62/Sequestosome 1 regulates transforming growth factor beta signaling and epithelial to mesenchymal transition in A549 cells.

Trelford, Charles B; Ng, Evelyn; Campbell, Craig I; Di Guglielmo, Gianni M.

Cell Signal; 85: 110040, 2021 09.

Artículo en Inglés | MEDLINE | ID: mdl-34000385

17.

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

Luga, Valbona; McLean, Sarah; Le Roy, Christine; O'Connor-McCourt, Maureen; Wrana, Jeffrey L; Di Guglielmo, Gianni M.

Biochem J; 421(1): 119-31, 2009 Jun 12.

Artículo en Inglés | MEDLINE | ID: mdl-19356148

18.

Assessing methods to quantitatively validate TGFß-dependent autophagy.

Trelford, Charles B; Di Guglielmo, Gianni M.

Biol Open; 9(11)2020 11 23.

Artículo en Inglés | MEDLINE | ID: mdl-33168592

19.

SMURF2 and SMAD7 induce SARA degradation via the proteasome.

Wojtowicz, Stephanie; Lee, Sanghyun; Chan, Eddie; Ng, Evelyn; Campbell, Craig I; Di Guglielmo, Gianni M.

Cell Signal; 72: 109627, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32283253

20.

The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2.

Soares, Iaci N; Viana, Raiane; Trelford, Charles B; Chan, Eddie; Thai, Boun; Cino, Elio A; Di Guglielmo, Gianni M.

Pharmacol Rep; 72(3): 631-640, 2020 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-32040844

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Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction.

Molecular mechanisms of mammalian autophagy.

Synthetic triterpenoids inhibit GSK3ß activity and localization and affect focal adhesions and cell migration.

Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.

The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells.

aPKC alters the TGFß response in NSCLC cells through both Smad-dependent and Smad-independent pathways.

Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration.

Expanding the Chemical Space of Transforming Growth Factor-ß (TGFß) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives.

Autophagy regulates transforming growth factor ß signaling and receptor trafficking.

Transforming growth factor-ß in tumour development.

Prolonged proteasome inhibition antagonizes TGFß1-dependent signalling by promoting the lysosomal-targeting of TGFß receptors.

Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.

Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.

TGF beta (transforming growth factor beta) receptor type III directs clathrin-mediated endocytosis of TGF beta receptor types I and II.

Canonical and Non-canonical TGFß Signaling Activate Autophagy in an ULK1-Dependent Manner.

p62/Sequestosome 1 regulates transforming growth factor beta signaling and epithelial to mesenchymal transition in A549 cells.

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

Assessing methods to quantitatively validate TGFß-dependent autophagy.

SMURF2 and SMAD7 induce SARA degradation via the proteasome.

The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2.